| 1. |
Physicochemical and Cytochemical Investigations on the Binding of Ethidium and Acridine Dyes to DNA and to Organelles in Living Cells |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 115-130
Herbert W. Zimmermann,
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摘要:
AbstractEthidium and acridine dyes are classical model substances for studying the binding of small, pharmacologically active molecules to DNA. Intercalation between the DNA base pairs is nearly always proposed as the most important type of binding. According to our investigations, however, there is a second type of binding, which also occurs when the concentration of the bound molecules is low and will be referred to here as external or preintercalative binding. The experimental binding isotherms show that the binding constant for intercalationKS1is considerably smaller than that for external bindingKS2(KS1>KS2). This surprising result is not due to the binding enthalpy (ΔH S10≈ ΔH S20) but to the binding entropy (ΔS S10>ΔS S20). Electrostatic interactions between the dye and the DNA represent the most important contribution to both types of binding; they are supplemented by hydrogen bonds and hydrophobic interactions. The behavior of a substance in living cells, however, cannot be reliably predicted from its in vitro binding to DNA. Very few substances are bound to the DNA of the nuclear chromatin in cell culture; for example, dyes often accumulate instead in the lysosomes. In some cases the dye binds specifically and very efficiently to the mitochondria of the living cell, especially to the mitochondrial membranes, the sites of oxidative ph
ISSN:0570-0833
DOI:10.1002/anie.198601153
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 2. |
Resonance Raman Spectroscopy, and Its Application to Inorganic Chemistry. New Analytical Methods (27) |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 131-158
Robin J. H. Clark,
Trevor J. Dines,
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摘要:
AbstractResonance Raman spectra are obtained when the wave number of the exciting radiation is close to, or coincident with, that of an electronic transition of the scattering species. Such spectra are usually characterized by a very large enhancement of the intensities of particular Raman bands, sometimes with the appearance of intense overtone and combination tone progressions. The technique provides detailed information about excited electronic states because it is only the vibrational modes associated with the chromophore that are resonance‐Raman active. Additionally, the high sensitivity is such that compounds at concentrations as low as 10−6mol/L may be detected, enabling resonance Raman spectroscopy to be used as an analytical tool and for the study of chromophores in molecules of biological inter
ISSN:0570-0833
DOI:10.1002/anie.198601311
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 3. |
The Ferrocenylmethyl(Fem) Group as a Highly Lipophilic and Chromophoric Group for the Masking of Peptide Bonds |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 159-160
Heiner Eckert,
Christoph Seidel,
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ISSN:0570-0833
DOI:10.1002/anie.198601591
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 4. |
α‐Deprotonation of an α‐Chiral 2‐Alkenylcarbamate with Retention and Lithium‐Titanium Exchange with Inversion— the Homoaldol Reaction with 1,3‐Chirality Transfer |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 160-162
Dieter Hoppe,
Thomas Krämer,
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ISSN:0570-0833
DOI:10.1002/anie.198601601
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 5. |
Novel Octahedral Si and Ge Complexes with a Hexadentate Diphenol Ligand |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 162-163
Bernardo Wolff,
Armin Weiss,
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ISSN:0570-0833
DOI:10.1002/anie.198601621
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 6. |
Decamethylsilicocene—Synthesis and Structure |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 164-164
Peter Jutzi,
Dieter Kanne,
Carl Krüger,
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ISSN:0570-0833
DOI:10.1002/anie.198601641
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 7. |
The Three‐Dimensionally Non‐Molecular Polyadamantanoid Structure of Cd(SPh)2 |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 165-166
Don Craig,
Ian G. Dance,
Robert Garbutt,
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ISSN:0570-0833
DOI:10.1002/anie.198601652
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 8. |
Vicinal Dilithioalkenes by Addition of Lithium to Simple Cyclic and Acyclic Alkynes |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 167-168
Adalbert Maercker,
Thomas Graule,
Ulrich Girreser,
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ISSN:0570-0833
DOI:10.1002/anie.198601671
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 9. |
1,2‐Dilithioethylene Isomers and Their Mechanisms of Interconversion: an Ab Initio Study |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 169-170
Paul von Ragué Schleyer,
Elmar Kaufmann,
Alexander J. Kos,
Timothy Clark,
John A. Pople,
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ISSN:0570-0833
DOI:10.1002/anie.198601691
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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| 10. |
Synthesis of the all‐L‐Configurated Cyclotetradepsipeptidecyclo[‐L‐Val‐L‐Lac‐]2by the Combined Protection/Activation Method with the 2,4‐Bis(methylthio)phenoxycarbonyl Group |
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Angewandte Chemie International Edition in English,
Volume 25,
Issue 2,
1986,
Page 170-171
Horst Kunz,
Hans‐Jürgen Lasowski,
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ISSN:0570-0833
DOI:10.1002/anie.198601701
出版商:Hüthig&Wepf Verlag
年代:1986
数据来源: WILEY
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