ISSN:0570-0833    

DOI:10.1002/anie.198308053

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

摘要:

AbstractThe majority of the 500 or so naturally occurring amino acids known today were discovered during the last 30 years, for example during the search for new antibiotics in the culture media of microorganisms, or as components of the antibiotics in fungi, seeds, in numerous plants and fruits, and in the body fluids of animals. Some 240 of these amino acids occur free in nature, some only as intermediates in metabolism. This article provides an overview of the developments that have taken place in this area since 1956 when the last review appeared. Summary accounts are presented, dealing with new unsaturated amino acids, cyclopropane‐ and cyclobutane‐amino acids, heterocyclic amino acids, halogen‐containing amino acids sulfur‐, selenium‐ and phosphorus‐containing amino acids as well as aliphatic amino acids. In a few cases,e. g.betalamic acid and muscaflavin, the biosynthesis is describe

ISSN:0570-0833    

DOI:10.1002/anie.198308161

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

摘要:

AbstractThe monoterpene glycoside secologanin is a key intermediate in the biosynthesis of most indole, cinchona, ipecacuanha, and pyrroloquinoline alkaloids, as well as of simple monoterpene alkaloids. More than a thousand alkaloids are formed from secologanin invivo; this represents almost a quarter of this large group of natural products. It is also the parent compound of the secoiridoids. Many of the compounds derived from secologanin display a high degree of biological activity and are employed as pharmaceuticals,e.g., the dimeric indole alkaloid leurocristine (vincristine) which is used very successfully in the treatment of acute leukemia. A knowledge of the biosynthesis and biological reactions of secologanin provides a sound basis for the biosynthesis‐orientated classification of numerous natural products and the taxonomy of many plants. Secologanin and structurally related substances can be synthesized in a few steps by stereocontrolled photochemical and thermal cycloadditions. Its biomimetic reaction with amines and amino acids yields other natural products and compounds of pharmacological interes

ISSN:0570-0833    

DOI:10.1002/anie.198308281

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

摘要:

AbstractRecombination of genetic material enables the creation of new bacterial strains which can synthesize specific proteins in large amounts. Such bacteria permit the production of previously inaccessible proteins. They can therefore be used as starting materials for the production of drugs which will open up new paths for therapy. Several proteins produced by bacteria after DNA recombination are presently undergoing clinical trials while others are already being produced on a large scale. Thus, in the area of recombinant DNA techniques the transition from the research laboratory to industrial exploitation has occurred much faster than was anticipated several years ago. The methods, possibilities and problems encountered in the synthesis of peptide hormones by bacteria after DNA recombination are outlined, using insulin, somatostatin, and growth hormone as examples. Great emphasis is placed on the molecular biological aspects of this approach.

ISSN:0570-0833    

DOI:10.1002/anie.198308421

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198308581

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

摘要:

AbstractThe complete manuscript of this communication appears in:Angew. Chem. Suppl. 1983, 1221. DOI:10.1002/anie.198312210

ISSN:0570-0833    

DOI:10.1002/anie.198308671

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

摘要:

AbstractThe complete manuscript of this communication appears in:Angew. Chem. Suppl. 1983, 1228. DOI:10.1002/anie.198312280

ISSN:0570-0833    

DOI:10.1002/anie.198308681

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

摘要:

AbstractThe complete manuscript of this communication appears in:Angew. Chem. Suppl. 1983, 1241. DOI:10.1002/anie.198312410

ISSN:0570-0833    

DOI:10.1002/anie.198308691

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

摘要:

AbstractThe complete manuscript of this communication appears in:Angew. Chem. Suppl. 1983, 1283. DOI:10.1002/anie.198312830

ISSN:0570-0833    

DOI:10.1002/anie.198308701

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198308711

出版商:Hüthig&Wepf Verlag    

年代:1983

数据来源: WILEY