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1. |
Graphical Abstract (Angew. Chem. Int. Ed. Engl. 7/1995) |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 705-710
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ISSN:0570-0833
DOI:10.1002/anie.199507051
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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2. |
Calixarenes, Macrocycles with (Almost) Unlimited Possibilities |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 713-745
Volker Böhmer,
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摘要:
AbstractThe condensation reaction betweenp‐tert‐butylphenol and formaldehyde leads in a single step to good yields of cyclic oligomers in which, depending on the reaction conditions, either four, six, or eight phenol units are joined by methylene bridges. The beakerlike shape of the most stable conformation of the tetramer has led to their being given the name “calixarenes” (calix = chalice). Resorcinol can undergo condensation in a similar manner with a variety of aldehydes to afford cyclic tetramers with the same basic structure (the resorcarenes). In both cases the reaction does not require the use of dilution techniques, so that large quantities of product can be readily obtained. In addition, the parent compounds can be modified in various ways, in particular at the phenolic hydroxy groups or the phenyl residues; these approaches can be used separately or in combination. Calixarenes are thus ideal starting materials for the synthesis of various types of host molecules and can also act as building blocks for the construction of larger molecular systems with defined structures and functions. Their potential applications range from use as highly specific ligands for analytical chemistry, sensor techniques and medical diagnostics to their use in the decontamination of waste water and the construction of artificial enzymes and the synthesis of new materials for non‐linear optics or for ultrathin layers and sieve membranes with molecu
ISSN:0570-0833
DOI:10.1002/anie.199507131
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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3. |
Carbon—Hydrogen Bonds of DNA Sugar Units as Targets for Chemical Nucleases and Drugs |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 746-769
Geneviève Pratviel,
Jean Bernadou,
Bernard Meunier,
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摘要:
AbstractThis review article focuses on the molecular aspects of DNA cleavage by synthetic chemical nucleases (transition metal complexes endowed with redox properties and DNA affinity) and natural drugs (cytotoxic agents such as bleomycins or enediynes). Unlike deoxyribonucleases, which catalyze the nucleophilic attack of water on the phosphorus atom of a particular phosphodiester entity, these nonhydrolytic DNA‐cleavers are able to oxidize the sugar units, generally by hydrogen atom abstraction. Examples of oxidative attack on each of the five different CH bonds of deoxyribose are known, depending on the nature, structure, type of activation, or mode of DNA interaction of the DNA‐cleaver. Further evolution at the site of the initial lesion leads to the release of bases, oxidized deoxyribose units, or oxidized sugar fragments appended to the base or the terminal phosphate. In most cases the loss of a part (at least) of a nucleoside, with the concomitant loss of one base information, primarily induces the cleavage of the DNA strand. For both types of DNA cleavage reagents studied within the two last decades, the modes of activation and DNA binding are presented, as well as the details on the mechanism of deoxyribose oxidative degration. Because of the need for highly efficient and highly specific reagents, the development of new artificial and selective DNA cleavers, supported by an improved knowledge of these different mechanisms of DNA cleavage, is to‐day a challenging area in the rational design of antitumoral or antiviral agents, as well as in the field of molecular
ISSN:0570-0833
DOI:10.1002/anie.199507461
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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4. |
The Dinuclear CuACenter in CytochromecOxidase and N2O Reductase—A Metal–Metal Bond in Biology? |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 771-773
Helmut Bertagnolli,
Wolfgang Kaim,
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ISSN:0570-0833
DOI:10.1002/anie.199507711
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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5. |
Total Syntheses of Zaragozic Acid |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 773-778
Ulrich Koert,
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ISSN:0570-0833
DOI:10.1002/anie.199507731
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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6. |
Modeling the Remote‐Controlled Organization of Particles in a Nanodimensional Cavity: Synthesis and Properties of (Et3NH)3(tBuNH3)2‐Na2[(H2O)2,N −3⊂ V14O22(OH)4(PhPO3)8]· 6H2O·2DMF |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 779-781
Achim Müller,
Kai Hovemeier,
Erich Krickemeyer,
Hartmut Bögge,
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ISSN:0570-0833
DOI:10.1002/anie.199507791
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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7. |
The Reactivity of 1,3‐Butadiyne Moieties in the “Exploding” [n]Rotanes—A Crown of Thiophenes |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 781-783
Sergei Kozhushkov,
Thomas Haumann,
Roland Boese,
Burkhardt Knieriem,
Stefan Scheib,
Peter Bäuerle,
Armin de Meijere,
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PDF (696KB)
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ISSN:0570-0833
DOI:10.1002/anie.199507811
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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8. |
A Simple, Chirogenic, Enantioselective Synthesis of Chlorins and Isobacteriochlorins |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 784-787
Dirk Kusch,
Elke Töllner,
Anngret Lincke,
Franz‐Peter Montforts,
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ISSN:0570-0833
DOI:10.1002/anie.199507841
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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9. |
Highly Stereoselective Allylation of Benzaldehyde: Generation of a Stereochemically Defined Allylzinc Species from a π‐Allylpalladium Intermediate and Diethylzinc |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 787-789
Yoshinao Tamaru,
Akihiro Tanaka,
Kengo Yasui,
Sachio Goto,
Shuji Tanaka,
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ISSN:0570-0833
DOI:10.1002/anie.199507871
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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10. |
Novel “π‐Boat” Cage Compounds as Potential Cryptands |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 7,
1995,
Page 789-791
Rolf Gleiter,
Kirstin Hövermann,
Joachim Ritter,
Bernhard Nuber,
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PDF (331KB)
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ISSN:0570-0833
DOI:10.1002/anie.199507891
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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