摘要:

AbstractPolarography is still the best known classical measuring method in electroanalytical chemistry. However, in recent years its position has been challenged by cyclic voltammetry (CV). Simple diagnostic criteria and relatively easily acquired measuring techniques have hastened this development. Cyclic voltammetry has the further attraction of providing information not only on the thermodynamics of redox processes but also on the kinetics of heterogeneous electron‐transfer reactions and coupled chemical reactions. The characteristic shapes of the voltammetric waves and their unequivocal position on the potential scale virtually fingerprint the individual electrochemical properties of redox systems. For this reason the method has been labeled “electrochemical spectrosco

ISSN:0570-0833    

DOI:10.1002/anie.198408313

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

摘要:

AbstractThe role played by prostaglandins (PGs) in the human body is bewitching. Following the elucidation of their structures in the early 1960s, tremendous efforts were made for the realization of an efficient chemical synthesis, since a sufficient supply of such very rare, naturally occurring local hormones relies solely on their total synthesis. Of the many synthetic routes described in the literature, the majority of which are linear or sequential in nature, the Corey synthesis is perhaps the most versatile; so far more than 5000 prostaglandin analogues have been prepared and have been tested biologically. Some natural prostaglandins and their analogues are already in clinical use. In view of the continuing expansion of this field, we have been fascinated with the concept of developing a highly convergent entry to prostaglandins based on a new strategy. The discovery of a highly enantioselective method for the reduction of prochiral ketones and the elaboration of a procedure for double vicinal CC‐coupling with enones have enabled a one‐pot synthesis of the complete prostaglandin skeleton by linking a chiral 4‐oxygenated 2‐cyclopentenone unit and two side‐chain blocks. This approach is efficient and flexible and allows the direct production of all the naturally occuring prostaglandins and a wide spectrum of

ISSN:0570-0833    

DOI:10.1002/anie.198408471

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

摘要:

AbstractRapidly accumulating evidence shows the value of asymmetric Diels‐Alder and ene reactions for the syntheses of enantiomerically pure molecules. This article presents a systematic and critical treatment of various stereoface‐differentiating principles, including very recent spectacular advances. The chiral information is mainly provided by covalently bound auxiliaries, some of which are crystalline, inexpensive, and readily available from naturally occurring monoterpenes, hydroxy acids, amino acids, steroids, and sugars. Non‐destructive transfer of chirality leads to the efficient creation of up to four chiral centers with predictable relative and absolute configurations. Regenerative cleavage of the auxilary group from the diastereomerically pure adducts furnishes a range of polyfunctional, optically pure building blocks. Their synthetic potential is illustrated by strategic applications to the syntheses of physiologically interesting, chiral natural products such as prostaglandins, antibiotics, terpenoids, shikimic acid, alkaloids, and kai

ISSN:0570-0833    

DOI:10.1002/anie.198408761

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198408901

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198408911

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198408921

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198408931

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198408941

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198408951

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198408961

出版商:Hüthig&Wepf Verlag    

年代:1984

数据来源: WILEY