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1. |
Graphical Abstract (Angew. Chem. Int. Ed. Engl. 2/1995) |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 131-137
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ISSN:0570-0833
DOI:10.1002/anie.199501311
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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2. |
Disulfide‐Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 141-154
R. Heiner Schirmer,
Joachim G. Müller,
R. Luise Krauth‐Siegel,
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摘要:
AbstractViewed globally, parasitic diseases such as malaria and Chagas' cardiopathy pose an increasing threat to human health and welfare. Recognition of this problem and the challenge of synthesizing a quinine‐like antimalarial agent sparked off the development of the chemical industry about 100 years ago. Our contribution deals with aspects of drug design, a young branch of pharmaceutical chemistry. As drug targets the flavoenzyme, glutathione reductase, and the recently discovered parasite enzyme, trypanothione reductase, were chosen. Based on the knowledge of the structure of these molecules, the modeling of enzyme inhibitors as potential chemotherapeutic agents against parasites has become possible. In addition, biochemical and clinical observations are considered since chemical principles of biological evolution can serve as guidelines for the pharmaceutical chemists. The picture shows two erythrocytes destroyed by malaria parasites. In the center of the photograph a parasite is just leaving its host cell through the ruptured cell membrane. Its target could be a neighboring healthy erythrocyt
ISSN:0570-0833
DOI:10.1002/anie.199501411
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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3. |
Design, Synthesis, and Properties of Molecule‐Based Assemblies with Large Second‐Order Optical Nonlinearities |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 155-173
Tobin J. Marks,
Mark A. Ratner,
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摘要:
AbstractThe design, synthesis, characterization, and understanding of new molecular and macromolecular assemblies with large macroscopic optical nonlinearities represents an active field of research at the interface of modern chemistry, physics, and materials science. Challenges in this area of photonic materials typify an important theme in contemporary chemistry: to create new types of functional materials by the rational construction of supramolecular assemblies exhibiting preordained collective phenomena by virtue of “engineered” molecule–molecule interactions and spatial relationships. This review surveys several approaches to, and the microstructural and optical properties of, second‐order nonlinear optical materials built from noncentrosymmetric assemblies of chromophores having large molecular hyperpolarizabilities. Such types of materials can efficiently double the frequency of incident light, exhibit other second‐order nonlinear optical effects, and contribute to the knowledge base needed for new photonic device technologies. Systems described include chromophore macromolecule guesthost matrices, chromophore‐functionalized glassy macromolecules, thermally crosslinked chromophore‐macromolecule matrices, and intrinsically acentric self‐assembled chromophori
ISSN:0570-0833
DOI:10.1002/anie.199501551
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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4. |
Peptide Ligases—Tools for Peptide Synthesis |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 175-177
Hans‐Dieter Jakubke,
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ISSN:0570-0833
DOI:10.1002/anie.199501751
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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5. |
Catalytic Asymmetric CC Bond Formation: New Enolato‐ and Organolithium Chemistry |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 178-180
David J. Berrisford,
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ISSN:0570-0833
DOI:10.1002/anie.199501781
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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6. |
Trace Analysis of the Radionuclides90Sr and89Sr in Environmental Samples I: Laser Mass Spectrometry |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 181-183
Jörg Lantzsch,
Bruce A. Bushaw,
Günter Herrmann,
Heinz‐Jürgen Kluge,
Ludwin Monz,
Sabine Niess,
Ernst W. Otten,
Richard Schwalbach,
Martin Schwarz,
Judith Stenner,
Norbert Trautmann,
Klaus Walter,
Klaus Wendt,
Klaus Zimmer,
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ISSN:0570-0833
DOI:10.1002/anie.199501811
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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7. |
Trace Analysis of the Radionuclides90Sr and89Sr in Environmental Samples II: Accelerator Mass Spectrometry (AMS) |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 183-186
Fatma Arslan,
Martin Behrendt,
Werner Ernst,
Eberhard Finckh,
Gunther Greb,
Friedrich Gumbmann,
Martin Haller,
Stefan Hofmann,
Ralf Karschnick,
Matthias Klein,
Wolfgang Kretschmer,
Jochen Mackiol,
Gerhard Morgenroth,
Christian Pagels,
Markus Schleicher,
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ISSN:0570-0833
DOI:10.1002/anie.199501831
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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8. |
Trace Analysis of the Radionuclides90Sr and89Sr in Environmental Samples III: Development of a Fast Analytical Method |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 186-189
Juan Alfaro,
Thomas Apfel,
Herbert Diercks,
Arndt Knöchel,
Rahul Sen Gupta,
Klaus Tödter,
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ISSN:0570-0833
DOI:10.1002/anie.199501861
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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9. |
Diastereoselective Coupling of Anodically Generated Radicals Bearing Chiral Amide Groups |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 189-191
Bruno Klotz‐Berendes,
Hans J. Schäfer,
Matthias Grehl,
Roland Fröhlich,
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ISSN:0570-0833
DOI:10.1002/anie.199501891
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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10. |
A Rhodium‐Mediated, Stepwise Trimerization of an Alkyne That Does Not Lead to a Benzene but Selectively to a Hexadienyne Derivative |
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Angewandte Chemie International Edition in English,
Volume 34,
Issue 2,
1995,
Page 191-194
Helmut Werner,
Martin Schäfer,
Justin Wolf,
Karl Peters,
Hans Georg von Schnering,
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PDF (605KB)
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ISSN:0570-0833
DOI:10.1002/anie.199501911
出版商:Hüthig&Wepf Verlag
年代:1995
数据来源: WILEY
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