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| 1. |
Graphical Abstract (Angew. Chem. Int. Ed. Engl. 7/1994) |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 701-707
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ISSN:0570-0833
DOI:10.1002/anie.199407011
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 2. |
Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 709-722
Wojciech J. Stec,
Andrzej Wilk,
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摘要:
AbstractEncouraging results obtained for modulation of gene expression by antisense oligonucleotides and their analogues have kindled hopes for a new generation of therapeutics against viral infections, cancer, and many other diseases. Among such analogues, oligo(nucleoside phosphorothioate)s (Oligo‐S) have generally shown the highest efficacy in inhibiting the biosynthesis of “unwanted” proteins. The first clinical trials of antisense agents are now in progress using Oligo‐S against genital warts and acute myeloid leukemia, and tests of Oligo‐S against AIDS should follow soon. Nevertheless, their mechanism of action, internalization, cellular trafficking, subcellular localization, and interaction with cellular proteins is still poorly understood. It is assumed a priori that application involves rapid and efficient molecular recognition of target RNA by Oligo‐S; however, the effects of the chirality of Oligo‐S have so far been unappreciated, because Oligo‐S has not yet been synthesized with stereocontrol. Indeed, the diastereomeric composition of Oligo‐S has never been determined, primarily because of the lack of appropriate analytical methods. Since each of the diastereomers is a stereochemically unique chemical entity, questions arise as to which diastereomer is responsible for an observed biological response, including positive (curative) or possibly negative (toxic) side effects.In this review we intend provide a perhaps somewhat speculative assessment of the problems associated with the stereo‐controlled synthesis of Oligo‐S and to discuss the state‐of‐the‐art in this field including strategies that may lead to Oligo‐S of predetermined chirality. This article is not intended to discourage researchers from further studies of dia‐steromeric mixtures of Oligo‐S as potential pharmaceuticals. Throughout the history of medicinal chemistry numerous useful medicines were discovered, developed, and employed without the detailed knowledge of their structure. Indeed, the composition of the vaccines discovered by Pasteur is a subj
ISSN:0570-0833
DOI:10.1002/anie.199407091
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 3. |
Ladder Sequencing of Peptides and Proteins—A Combination of Edman Degradation and Mass Spectrometry |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 723-725
Jörg W. Metzger,
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ISSN:0570-0833
DOI:10.1002/anie.199407231
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 4. |
A Structural Model for the Water‐Oxidizing Manganese Cluster in Photosystem II |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 725-728
Karl Wieghardt,
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ISSN:0570-0833
DOI:10.1002/anie.199407251
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 5. |
Resolution of Racemates by Distillation with Inclusion Compounds |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 728-729
Gerd Kaupp,
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ISSN:0570-0833
DOI:10.1002/anie.199407281
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 6. |
Metallocorroles with Formally Tetravalent Iron |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 731-735
Emanuel Vogel,
Stefan Will,
Andreas Schulze Tilling,
Ludger Neumann,
Johann Lex,
Eckhard Bill,
Alfred X. Trautwein,
Karl Wieghardt,
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ISSN:0570-0833
DOI:10.1002/anie.199407311
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 7. |
μ‐Oxodiiron(III) Complexes of Porphycenes |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 736-739
Michael Lausmann,
Ingeborg Zimmer,
Johann Lex,
Heiko Lueken,
Karl Wieghardt,
Emanuel Vogel,
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ISSN:0570-0833
DOI:10.1002/anie.199407361
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 8. |
Concerning the Questionable Existence of Thioxoindigoid Compounds |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 739-741
Werner Schroth,
Ekkehard Hintzsche,
Michael Felicetti,
Roland Spitzner,
Joachim Sieler,
Rhett Kempe,
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ISSN:0570-0833
DOI:10.1002/anie.199407391
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 9. |
The Reactivity of Phosphacymantrenes towards Palladium(II) and Palladium(0) Compounds: Synthesis, Structure, and Chemistry of Pd2Mn2and Pd3Mn4Arrays |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 742-745
Lionel Brunet,
François Mercier,
Louis Ricard,
François Mathey,
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ISSN:0570-0833
DOI:10.1002/anie.199407421
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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| 10. |
New Sulfur‐ and Selenium‐Bridged Copper Clusters; Ab Initio Calculations on [Cu2nSen(PH3)m] Clusters |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 7,
1994,
Page 746-749
Stefanie Dehnen,
Ansgar Schäfer,
Dieter Fenske,
Reinhart Ahlrichs,
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ISSN:0570-0833
DOI:10.1002/anie.199407461
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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