摘要:

AbstractProstaglandins continue to be a major and fast‐developing area of research in the chemical and biological sciences. Increasing evidence has recently prompted some researchers to suggest that the important physiological actions of these hormones are exerted by their unstable arachidonic acid pathway intermediates, the endoperoxides, thromboxanes, and prostacyclin. The importance of these substances in physiology and medicine and the challenge they pose to synthetic chemistry place them in the forefront of chemical and biochemical investigation. Current biological research has greatly benefited by synthetic advances which have made available large quantities of some of these naturally occurring intermediates and several analogs with increased stabilities. Following a brief review of the primary prostaglandins, the present article describes recent biosynthetic developments, partial and total syntheses of prostaglandin endoperoxide analogs, thromboxane B2, and prostacyclins, and the biological properties of these molecule

ISSN:0570-0833    

DOI:10.1002/anie.197802933

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

摘要:

AbstractOrganometallic compounds of the alkali metals undergo concerted [1,n] sigmatropic migration of aryl, vinyl, carbonyl, alkoxycarbonyl, silyl, germyl, and related groups. Sigmatropic migration of alkyl, benzyl, and hydrogen occur only under special circumstances and then may occur by an alternate fragmentation‐recombination pathway. Allyl groups may migrate by the latter process or by a concerted [2,3]sigmatropic reaction. These molecular rearrangements are discussed from the viewpoint of simple molecular orbital theory. By suitable choice of the alkali metal, temperature, ligands of the alkali cation and/or the solvent, considerable control may be exercised over the rate of rearrangement, the relative migratory aptitude of groups, and the mechanistic pathwa

ISSN:0570-0833    

DOI:10.1002/anie.197803131

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

摘要:

AbstractCompelling evidence for the intermediacy of vinyl cations has accumulated in recent years. Vinyl cations can be generated by electrophilic additions to alkynes and allenes, and on participation of such functions in solvolysis reactions. Heterolysis of vinyl compounds likewise affords vinyl cations. Syntheses of substituted indenes, cyclobutanones, and cyclopropyl ketones illustrate preparative applications.

ISSN:0570-0833    

DOI:10.1002/anie.197803331

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

摘要:

AbstractIn this article experimental findings and new theories concerning the chemical structure and biological function of histocompatibility antigens in the immune surveillance of virus‐infected and malignant cells are discussed. Amongst these antigens, the H‐2 antigens of the mouse have been studied most extensively. They are membrane bound glycoproteins causing the rejection of transplants from foreign tissue. One future aim of this field of research is to utilize the immune surveillance system in the therapy of diseases which as yet cannot be trea

ISSN:0570-0833    

DOI:10.1002/anie.197803421

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.197803511

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.197803521

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.197803531

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.197803541

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.197803551

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.197803561

出版商:Hüthig&Wepf Verlag    

年代:1978

数据来源: WILEY