1. |
Graphical Abstract (Angew. Chem. Int. Ed. Engl. 19/1994) |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1897-1902
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ISSN:0570-0833
DOI:10.1002/anie.199418971
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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2. |
Prostacyclin and Thromboxane Synthase: New Aspects of Hemethiolate Catalysis |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1911-1919
Volker Ullrich,
Roland Brugger,
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摘要:
AbstractThe arachidonic acid metabolites thromboxane A2and prostacyclin are highly potent regulators of cell physiology. They are both formed by enzymatic rearrangement of the 9,11‐epidioxy prostaglandin H2catalyzed, however, by thromboxane and prostacyclin synthase, respectively. The two enzymes have been isolated, sequenced, and characterized as hemethiolate (“P450”) enzymes. The different isomerization products can be explained on the same catalytic principle by a different ligation of the heme centers with the two epidioxy oxygens atoms. This requires different conformations for substrate binding at the active site, which is substantiated by the different inhibitors and amino acid sequences of the enzymes. In a hypothesis which has mechanistic principles in common with the P450‐monooxygenases and the allene oxide synthases, oxy radicals are formed first and rearrange to carbon radicals. These could then rapidly be converted into carbocations by the ferrylthiolate or iron(III)thiyl structures formed as interm
ISSN:0570-0833
DOI:10.1002/anie.199419111
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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3. |
Toxicity of Chlorinated Organic Compounds: Effects of the Introduction of Chlorine in Organic Molecules |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1920-1935
Dietrich Henschler,
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摘要:
AbstractIndustrial “chlorine chemistry” is accused of polluting the environment with its products and having adverse effects on health. The accusation has been followed by the demand that this ill‐defined branch of chemistry be simply abolished, a demand which has been repeated vigorously now for years. It grew out of misgivings such as those summarized here: 1. A number of polychlorinated cyclic compounds are very stable and highly lipophilic so that they accumulate in the environment and affect mankind through the food chain. Prominent examples are chlorinated pesticides, biphenyls, dibenzodioxins, and dibenzofurans. 2. Many chlorinated compounds are toxic for man and animals. Their genotoxicity (mutagenicity and carcinogenicity) plays a role in risk assessment; more and more chlorinated organic compounds are being shown to be carcinogenic and classified accordingly.To date there are no comprehensive reviews of the toxicology of chlorinated organic compounds. The present treatise is the result of an attempt to analyze the situation systematically. It makes generalizations as to the kind and degree of toxicity of the most important classes of chlorinated organic compounds and elaborates recommendations for reduction and avoidance of risk during production, occupational handling, and genera
ISSN:0570-0833
DOI:10.1002/anie.199419201
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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4. |
Bolaamphiphiles: From Golf Balls to Fibers |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1937-1940
Gregory H. Escamilla,
George R. Newkome,
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ISSN:0570-0833
DOI:10.1002/anie.199419371
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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5. |
Molecules and Ions with Heptacoordinated Central Atoms |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1941-1942
Rolf Minkwitz,
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ISSN:0570-0833
DOI:10.1002/anie.199419411
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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6. |
Rb3[Nb6SBr17], the First Compound Containing an Isolated Trigonal‐Prismatic Niobium Cluster |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1943-1944
Hermann Womelsdorf,
H.‐Jürgen Meyer,
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ISSN:0570-0833
DOI:10.1002/anie.199419431
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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7. |
O‐Glycoside Syntheses under Neutral Conditions in Concentrated Solutions of LiClO4in Organic Solvents |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1944-1946
Herbert Waldmann,
Gerd Böhm,
Uschi Schmid,
Herbert Röttele,
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ISSN:0570-0833
DOI:10.1002/anie.199419441
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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8. |
Doubly Bridgedrac‐Metallocenes of Zirconium and Hafnium |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1946-1949
Wolfgang A. Herrmann,
Marcus J. A. Morawietz,
Thomas Priermeier,
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ISSN:0570-0833
DOI:10.1002/anie.199419461
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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9. |
Iron‐Promoted, Regio‐ and Stereoselective Allylic Substitutions for the Synthesis of Alkenyl Sulfones Substituted at C‐3 |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1949-1951
Dieter Enders,
Bernd Jandeleit,
Gerhard Raabe,
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ISSN:0570-0833
DOI:10.1002/anie.199419491
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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10. |
α‐Aryliodonio Diazo Compounds: SNReactions at the α‐C Atom as a Novel Reaction Type for Diazo Compounds |
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Angewandte Chemie International Edition in English,
Volume 33,
Issue 19,
1994,
Page 1952-1953
Robert Weiss,
Jörg Seubert,
Frank Hampel,
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ISSN:0570-0833
DOI:10.1002/anie.199419521
出版商:Hüthig&Wepf Verlag
年代:1994
数据来源: WILEY
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