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1. |
The Enchanting Alkaloids of Yuzuriha |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 665-681
Clayton H. Heathcock,
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摘要:
AbstractThe oriental plant Yuzuriha (Daphniphyllum macropodum) elaborates a fascinating family of polycyclic, squalene‐derived alkaloids that provide a test for state‐of‐the‐art methods of organic synthesis. The intriguing structures of these natural products have inspired us to design and explore two rather different approaches for their laboratory synthesis. This article recounts and contrasts these two different syntheses. The first approach was based on a method of synthetic design that emphasizes efficient construction of the polycyclic skeleton of the molecule (Corey's “network analysis”). A strategic bond was identified and the synthesis planned around the late formation of this bond. The synthesis that was designed by this approach proceeded smoothly until the point where it was necessary to remove functional groups that had been incorporated solely for the purpose of forming the strategic bond. Although the problems were eventually overcome, the resulting synthesis was too long and did not control the configuration of one of the stereocenters. The second approach was based on a possible biosynthesis of one of the alkaloids and provided surprisingly easy access to the simpler members of the family. The success of this synthesis led to a concrete proposal about the biosynthesis of the alkaloids and to the discovery of the astonishing transformation depicted in Scheme 27. In this marvelous reaction, an acyclic squalene derivative is converted by successive treatment with ordinary commodity chemicals into a pentacyclic alkaloid. The transformation involves the formation of four carbon–carbon bonds, two carbon‐nitrogen bonds, and one carbo
ISSN:0570-0833
DOI:10.1002/anie.199206653
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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2. |
Transition Structures of Hydrocarbon Pericyclic Reactions |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 682-708
Kendall N. Houk,
Yi Li,
Jeffrey D. Evanseck,
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摘要:
AbstractTwenty‐five years after the discovery of a vast class of organic reactions named “pericyclic reactions” by Woodward and Hoffmann, ab initio quantum mechanics provides a detailed analysis of the geometries, energies, and electronic characteristics of the transition structures of these reactions. Common features are found in all these reactions, and generalizations permit prediction of other transition‐structure geometries and energies. At the same time, great diversity is observed—from strongly bonded, rigid, closed‐shell entities to weakly interacting, flexible diradical
ISSN:0570-0833
DOI:10.1002/anie.199206821
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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3. |
Synthetic Bilayer Membranes: Molecular Design, Self‐Organization, and Application |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 709-726
Toyoki Kunitake,
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摘要:
AbstractLipid bilayers are a most central building block of the biological molecular organization. Their two‐dimensional self‐assembly is essential to the generation of biological shapes and sizes on the molecular level. The observation that a totally synthetic amphiphile in water is spontaneously assembled to a bilayer structure suggested that bilayer formation is a general physicochemical phenomenon that is not restricted to particular structures of biolipid molecules. Bilayer formation is now observed for a large variety of synthetic amphiphiles which contain one, two, three, or four alkyl tails. The flexible alkyl tail may be replaced by perfluoroalkyl chains. The supramolecular structures obtained therefrom can be related to the component's molecular structure in many cases. The structural variety and the ease of molecular design make the synthetic bilayer an attractive vehicle for organizing covalently bound functional units and guest molecules. In addition, stable monolayers on water, planar lipid membranes (BLM), and free‐standing cast films are obtainable because of the self‐assembling property of bilayer‐forming compounds. These molecular organizations display common supramolecular features. The use of the cast film as a molecular template provides exciting potential for the production of novel two‐dimensiona
ISSN:0570-0833
DOI:10.1002/anie.199207091
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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4. |
Are Denser Packings of Spheres than Closest Packings Possible? How Many Closest Packings of Spheres Exist? |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 727-728
Ulrich Müller,
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ISSN:0570-0833
DOI:10.1002/anie.199207271
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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5. |
Oxazaborolidines and Dioxaborolidines in Enantioselective Catalysis |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 729-730
Braj B. Lohray,
Vidya Bhushan,
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ISSN:0570-0833
DOI:10.1002/anie.199207291
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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6. |
Penetrated Ion Pairs: a New Form of Ion Pair |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 731-732
Gernot Boche,
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ISSN:0570-0833
DOI:10.1002/anie.199207311
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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7. |
Self‐Assembly of a Cu4Complex with Coplanar Copper(I) Ions: Synthesis, Structure, and Electrochemical Properties |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 733-735
Marie‐Thérèse Youinou,
Noureddine Rahmouni,
Jean Fischer,
John A. Osborn,
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ISSN:0570-0833
DOI:10.1002/anie.199207331
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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8. |
Alkoxyalkyl‐Substituted β‐Diketonate Complexes of Barium and Copper: Evidence for Inter‐ and Intramolecular Stabilization |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 735-737
William S. Rees,
Celia R. Caballero,
Werner Hesse,
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ISSN:0570-0833
DOI:10.1002/anie.199207351
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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9. |
The First Complex with a σ2π4Triple Bond between Vanadium Atoms in a Ligand Framework of Fourfold Symmetry—[V2{(p‐CH3C6H4)NC(H)N(p‐C6H4CH3)}4] |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 737-738
F. Albert Cotton,
Lee M. Daniels,
Carlos A. Murillo,
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ISSN:0570-0833
DOI:10.1002/anie.199207371
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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10. |
How High is the Barrier for the Valence Isomerization of Cyclobutadiene? |
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Angewandte Chemie International Edition in English,
Volume 31,
Issue 6,
1992,
Page 738-740
Gunther Maier,
Reinhard Wolf,
Hans‐Otto Kalinowski,
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ISSN:0570-0833
DOI:10.1002/anie.199207381
出版商:Hüthig&Wepf Verlag
年代:1992
数据来源: WILEY
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