摘要:

AbstractThis article assesses the importance of molecular preorganization to the rapidly developing field of complexation involving designed synthetic organic compounds. Since its birth as a science, organic chemistry has drawn heavily on biological chemistry as a vast storehouse of evolutionary structures, reactions, and control mechanisms that serve as inspiration for designed organic‐compounds mimics. Biological systems, through highly structured complexation, accomplish complicated tasks. The receptor sites of enzymes, the genes, the antibodies, and ionophores possess high degree of preorganization. In other words, their functional groups act cooperatively as binding or catalytic sites which are largely collected and oriented prior to complexation.—The strength of the organic chemist derives from his ability to design organic compounds, organic reactions, synthetic sequences, and test systems to evaluate hypotheses. The design of highly structured complexs and the discovery of the rules that govern their behavior are described here. Research in this field is particularly rewarding because scientific and aesthetic content merge and become visible in the structures of many of the comple

ISSN:0570-0833    

DOI:10.1002/anie.198610393

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractAs a normal attribute of aerobic life, structural damage to organic compounds of a wide variety (DNA, proteins, carbohydrates and lipids) may occur as a consequence of oxidative reactions. Oxidative damage inflicted by reactive oxygen species has been called “oxidative stress”. Biological systems contain powerful enzymatic and nonenzymatic antioxidant systems, and oxidative stress denotes a shift in the prooxidant/antioxidant balance in favor of the former. Diverse biological processes such as inflammation, carcinogenesis, ageing, radiation damage and photobiological effects appear to involve reactive oxygen species. This field of research provides new perspectives in biochemical pharmacology, toxicology, radiation biochemistry as well as pathophysiol

ISSN:0570-0833    

DOI:10.1002/anie.198610581

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

摘要:

AbstractReactions of metal atoms with molecular hydrogen and alkanes are prototypical of more complex systems involving metal‐mediated reactions in solution, on supports, and on surfaces. The simplicity of metal‐atom reactions makes them particularly attractive for fundamental experimental and theoretical studies. Following the first reports of H2and CH4activation by photoexcited metal atoms in cryogenic matrices, the behavior of a number of transition‐metal atoms in their ground and selected electronically excited states has been examined with molecular hydrogen, methane, and ethane. A wealth of structural, electronic, reactivity, and selectivity information is emerging from these studies and it is now becoming possible to recognize the controlling factors at work in these fundamental chemical reactions. In this article, some experimental results for a number of metal‐atom systems, in particular, those involving silver, copper, manganese, and iron atoms, are presented along with a discussion of the factors that are believed to be important in the understanding of the observed physical and chemical b

ISSN:0570-0833    

DOI:10.1002/anie.198610721

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198610861

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198610871

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198610891

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198610901

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198610921

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198610931

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY

ISSN:0570-0833    

DOI:10.1002/anie.198610961

出版商:Hüthig&Wepf Verlag    

年代:1986

数据来源: WILEY