| 1. |
The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1671-1690
Constant A. A. van Boeckel,
Maurice Petitou,
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摘要:
AbstractHeparin, a sulfated glycosaminoglycan, is well known for its anticoagulant effect mediated by the serine protease inhibitor antithrombin III (AT III). Heparin has been used clinically for more than half a century for the prophylaxis and treatment of venous thrombosis and thromboembolism. Up until the 1980s it was assumed that the biological activity of heparin was mainly caused by its polyanionic character. However, this paradigm was contradicted when it was discovered that part of the heparin polysaccharides contains a well‐defined pentasaccharide domain that specifically binds and activates AT III. The specificity of the interaction between the characteristic pentasaccharide and AT III has become more obvious after the synthesis and biological testing of various heparin analogues. This article reviews the synthesis of the heparin pentasaccharide, some closely related counterparts, and some highly modified analogues. With the aid of molecular modeling and through “tailored” molecular modifications of the pentasaccharide, much knowledge has been gained concerning structure‐activity relationships. On this basis not only have more potent and simplified derivatives been developed, but also the recognition between heparin and AT III can now be understood in greater detail at the molecula
ISSN:0570-0833
DOI:10.1002/anie.199316713
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 2. |
Got the Flu? Try a Designer Agent Derived from a Sugar |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1691-1693
Carlo Unverzagt,
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ISSN:0570-0833
DOI:10.1002/anie.199316911
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 3. |
Electrochemical Production of Zinti Anions: Renaissance of a Synthesis Route** |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1693-1695
Brigitte Eisenmann,
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ISSN:0570-0833
DOI:10.1002/anie.199316931
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 4. |
Regiospecific Alkylation of 6‐Chloropurine and 2,6‐Dichloropurine at N7 by Transient Protection of N3/N9 by Methylcobaloxime |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1696-1697
Christine Dalby,
Christine Bleasdale,
William Clegg,
Mark R. J. Elsegood,
Bernard T. Golding,
Roger J. Griffin,
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ISSN:0570-0833
DOI:10.1002/anie.199316961
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 5. |
A Novel Complex with Boat‐Shaped, Synfacially Bound η3:η3‐Benzene Bridges and the First μ3‐η2:η2:η2‐Arenetrirhodium Complex |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1697-1699
Jörn Müller,
Petra Escarpa Gaede,
Ke Qiao,
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ISSN:0570-0833
DOI:10.1002/anie.199316971
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 6. |
A Synthetic Cavity Assembles Through Self‐Complementary Hydrogen Bonds |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1699-1701
René Wyler,
Javier de Mendoza,
Julius Rebek,
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ISSN:0570-0833
DOI:10.1002/anie.199316991
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 7. |
A Hexanuclear Organogallium Fluoride Oxide |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1701-1702
Bernhard Neumüller,
Frank Gahlmann,
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ISSN:0570-0833
DOI:10.1002/anie.199317011
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 8. |
Dicyanononasulfane S9(CN)2—An Unbranched Chain of Thirteen Atoms |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1702-1703
Ralf Steudel,
Klaus Bergemann,
Jürgen Buschmann,
Peter Luger,
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ISSN:0570-0833
DOI:10.1002/anie.199317021
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 9. |
Lipophilic 5′,5′‐O‐Dinucleoside‐α‐hydroxybenzylphosphonic Acid Esters as Potential Prodrugs of 2′,3′‐Dideoxythymidine (ddT) |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1704-1706
Chris Meier,
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ISSN:0570-0833
DOI:10.1002/anie.199317041
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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| 10. |
Tricyclo[6.2.0.03,6]deca‐1,3,6,8‐tetraene: A Remarkably Stablepara‐Quinodimethane from a Novel Rearrangement Reaction |
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Angewandte Chemie International Edition in English,
Volume 32,
Issue 12,
1993,
Page 1706-1709
Jan‐Dirk van Loon,
Paul Seiler,
François Diederich,
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ISSN:0570-0833
DOI:10.1002/anie.199317061
出版商:Hüthig&Wepf Verlag
年代:1993
数据来源: WILEY
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