ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Borderline malignancy has become a popular but very loosely used term. It is used in a variety of soft tissue tumors to connote different biologic behaviors or potential and, as such, it has ceased to be a meaningful concept, even if it may be useful as an expression of uncertainty in daily practice. In reviewing soft tissue tumors that are commonly regarded as borderline malignant, it seems that much uncertainty seems from failure to properly define malignancy and to understand mechanisms of malignant behavior in the specfic setting of mesenchymal neoplasia.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Histologic grade has been shown repeatedly to be the most important prognostic factor in adult soft tissue sarcomas with regard to metastasis development and tumor morrality, although tumor size and tumor location (superficial versus deep) are also important parameters to consider. In this review, the advantages and limitations of histrologic grade are exposed, focusing on the grading system of the Fédération Nationale des Centres de Lutte Contre fe Cancer. The reproducibility issue and the impact of histologic grade on patient management are also discussed.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Fine needle aspiration (FNA), used as a diagnostic tool in the primary diagnosis of soft tissue tumors, has never been critically examined. On the basis of 25 years of experience at the Musculoskeletal Tumour Centre in Lund, Sweden, the benefits, limitations, and requirements for optimal use of FNA and cytodiagnosis in the definitive treatment of soft tissue tumors are discussed. The benefits of FNA outweigh the limitations when the following requirements are fulfilled: referral of patients to specialist centers according to specific guidelines, a multidisciplinary approach to reach a reliable pretreatment diagnosis, and close cooperation among the different specialists involved, especially between the cytopathologist and the orthopedic surgeon.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

The Cellular schwannoma, a benign tumor related to the conventional schwannoma, must be distinguished from malignant histologic simulators such as malignant peripheral nerve sheath tumors and sarcomas. Familiarity with comparative features of these tumors may prove helpful in the setting of an intraoperative frozen section.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Synovial sarcomas sometimes have areas where cells are more pleomorphic and mitotically active than usual, and which can display necrosis. These appearances predominate in approximately 20% of cases. These tumors, termedpoorly differentiated synovial sarcomas,are aggressive; the clinical course can be prolonged. It is important to distinguish poorly differentiated synovial sarcomas from other soft tissue sarcomas. This may be difficult, especially in a small biopsy specimen, because the neoplastic cells can be rounded, polygonal, rhabdoid, or spindled, and thus resemble those of many other tumors. Because the immunohistochemical profiles of poorly differentiated synovial sarcomas and morphologically similar tumors can overlap, a panel of antibodies and, if necessary, electron microscopy should be used. Demonstration of the specific translocation t(x;18) (p11.2;q11.2) confirms the diagnosis.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

It is likely that inflammatory myofibroblastic tumor represents a continuum of tumorous lesions characterized by myofibroblastic and fibroblastic proliferation with a prominent inflammatory infiltrate. It has been described in almost every anatomic site, and the majority of cases pursue a benign clinical course; however, anatomic location may dictate biologic behavior somewhat. In particular, retroperitoneal and mesenteric tumors are particularly problematic; rare examples of multiple recurrences with histologic sarcomatous progression and of distant metastasis have been observed from tumors at these locations, and the designation of inflammatory fibrosarcoma perhaps should be reserved for these uncommon cases. Although the precise cause of these lesions remains elusive, with several lines of evidence suggesting either an infectious, inflammatory, or autoimmune origin, cases with clonal cytogenetic abnormalities and aneuploidy have been reported, suggesting that some lesions represent true neoplasms.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Florid reactive periostitis is a nonneoplastic reactive process that originates in the periostium. Usually, it arises on the short tubular bones of the hands and presents as a tender, rapidly growing mass: partial mineralization may be seen on radiographic examination. Histologically, it is composed of an admixture of reactive, hypercellular fibrous tissue and woven bone that has a trabecular pattern. Some cases have a cap of reactive cartilage on the surface. Osteosarcoma is the most important tumor to exclude in the histologic differential diagnosis. Simple excision is the treatment of choice. The prognosis is excellent; few cases recur.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Low-grade myxofibrosarcoma represents the lowest grade end of the morphologic specturm of what has often been known as myxoid “malignant fibrous histiocytoma.” Because of its relative hypocellularity it is commonly mistaken for a benign neoplasm or recative process, yet the degree of nuclear atypia exceeds that seen in any benign myxomatous lesion. Although low-grade myxofibrosarcoma seems never to metastasize, nevertheless it commonly recurs locally: in such recurrences it may progress to a higher grade lesion with metastatic potential. As such, accurate diagnosis and thus appropriate treatment are essential to ensure a good outcome in this potentially curable neoplasm.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

A case of dedifferentiated liposarcoma arising in the right orbital region of a 29-year-old man is reported. The clinical and histopathologic features of dedifferentiated liposarcoma are discussed in detail.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID