ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

With development of novel and highly differentiated therapeutic strategies in neuro-oncology, the role of the pathologist as a member of the multidisciplinary neuro-oncology them became central and earries even greater responsibility. It is on the basis of the pathologic diagnosis that critical inferences about the natural history and prognosis of the disease are made and treatment plans, often including radiation and chemotherapy, follow. Proper classification and grading of brain tumors become essential in speaking a common language and avoiding, potentially dangerous misunderstandings.1This particularly applies to gliomas, the most common primary brain tumors, which comprise a large spectrum of neoplasms with extremely different natural history, biologic aggressiveness., and prognosis. Rigid adherence to a diagnostic algorithm, which takes into Account characteristic; clinical, neuroimaging, and pathologic features is essential. In the present article, we will focus on classification and grading criteria of diffuse gliomas, comprising astrocytic, oligodcndroglial, and mixed neoplasms, aiming to yield a simple, precise, and unequivocal tumor designation.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Pituitary hyperplasia is an uncommon condition that is difficult to diagnose, especially in small fragmented surgical specimens. Normal pituitary cells show variations in distribution, another factor complicating the identification of hyperplasis on biopsy. The process may be nodular or diffuse. It is the nodular variety that readily lends itself to histologic diagnosis. The condition affects most pituitary cell types including prolactin, growth hormone, corticotropin and thyrotropin-producing cells. Herein the authors present these various forms of piruitary hyperplasia with comments regarding their clinical presentations and the implications of making or not making a correct diagnosis.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

In spite of the common designation as a form of astrocytoma, pilocytic and fibrillary (diffuse) lesions are two distinct entities. One, the pilocytic, is generally discrete and hesitatingly invasive, slow-growing, and histologically stable over prolonged periods. The other, the fibrillary type, is infiltrating, rapidly growing in higher grade types, and prone to malignant degeneration. In light of the prognostic and therapeutic implications of the designations, every effort should be made to distinguish these lesions along the guidelines presented in this aricle.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

A 51-year-old woman underwent resection of a parasagittal mass. Histology revealed a transitional meningioma graded as atypical on the basis of a mitotie index of up to found mitoscs per 10 high-power fields. A recurrence 20 months later displayed focal rhabdoid morphology, an increased mitotic index, and brain invasion. Despite surgery and adjuvant radiation therapy, a second recurrence necessitated resection 3 months later. Histologically the rhabdoid component had become more prominent and features of frank anaplasia were seen. Despite the surgeon's impression that a gross total resection was achieved, a third recurrence was detected after only 3 months. The recently recognized rhabdoid meningloma variant and histologic features of prognostic significance in meningioma grading are discussed.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

A typical retratoid/thabdoid tumor (AT/RT) of the contral nervous system (GNS) is a recently described infantile brain turmor exhibiting unusually aggressive clinical behavior, i.e., a greater than 80% mortality at 1 year. Although often mistaken for primitive neuroectodermal tumor (PNET)/medulloblastoma because of its frequent posterior fossa location. It does not respond to standard PNET treatment protocols. Fottunatelly, its histologic features, immunophenotype, and cytologic profile are distinctive. The recognition of AT/RT is extremely important because appropriate treatment may influence the natural history of the disease.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

Because nonneoplastic and reactive conditions of the central nervous system (CNS) may often mimic tumor? in their clinical and radiologic presentation, their distinction by biopsy sample may prove a challenge. Acute inflaminatory demyelinating disease, especially multiple sclerosis (MS), is of importance in this regard, but a variety of infections and other lesions come into consideration. We describe a practical Approach to the diagnosis of tumorlike lesions, one aimed at The avoidance of pathologist error. The use. of neuroimaging studies in differential diagnosis is emphasized throughout.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

摘要:

A60-year-old obese white, male with chronic migraine headaches had a positive family history of presenile dementia, His father died at age 51, also with a history of migraine. Magnetic resonance imaging studies showed leukoencephalopathy consistent with subcortical infarcts. From neuro-imaging studies, a.diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencepljahipathy (CADASIL) had been suspected, It had not been histologically confirmed in the father, A punch biopsy of skin was obtained.

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID

ISSN:1082-9784    

出版商:OVID    

年代:1998

数据来源: OVID