ISSN:1082-9784    

出版商:OVID    

年代:2003

数据来源: OVID

ISSN:1082-9784    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

The idiopathic interstitial pneumonias are a subgroup of the wide spectrum of diffuse parenchymal lung diseases and were first classified over 30 years ago by Liebow and Carrington. Then, like now, the emphasis was on the recognition of prognostically distinct subgroups. A recent consensus classification system has been published by an American Thoracic Society/European Society-sponsored committee comprising clinicians, radiologists, and pathologists. This classification attempts to divide the interstitial lung diseases into as homogeneous categories as possible. This not only helps in individual patient prognostication, but could allow tailoring of therapy to the individual patient in ways not previously possible. The newest member of the interstitial lung diseases recognized by this classification, nonspecific interstitial pneumonia, was described in its current form less than 10 years ago and most of the available information on this pattern has been published in the last 5 years. This review describes the pathologic features of this pattern, its radiologic and clinical features, the relationship to previously recognized patterns of interstitial lung disease, and what is known about its biology.

ISSN:1082-9784    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

In the past, a definitive diagnosis of pulmonary lymphoma, particularly low-grade variants, required transbronchial or open lung biopsy. With recent advances in ancillary methods such as immunophenotyping, cytogenetic and molecular testing, a diagnosis and classification of lymphoma is increasingly made on the basis of cytologic samples obtained by fine needle aspiration (FNA). We report a case of a 61-year-old man with a history of renal cell carcinoma who presented with multiple pulmonary nodules. A percutaneous lung FNA was interpreted at an outside institution as metastatic renal cell carcinoma. On review, we felt that the atypical cells initially interpreted as carcinoma were reactive mesothelial and alveolar cells. Repeat FNA revealed a mixture of lymphocytes and benign epithelial cells. The lymphocytes were predominantly small and uniform with slight nuclear membrane irregularity and small nucleoli. Scattered plasma cells and immunoblasts were also present. Immunophenotyping by flow cytometry showed a monoclonal population of CD5-negative, CD10-negative B-lymphocytes. A diagnosis of bronchus-associated lymphoid tissue (BALT) lymphoma was made. The patient is stable without treatment 4.5 years later. We propose that FNA cytology combined with flow cytometry be used for the initial diagnosis of pulmonary lymphoma. More invasive diagnostic procedures such as open biopsy should be reserved for cases in which FNA is unsuccessful.

ISSN:1082-9784    

出版商:OVID    

年代:2003

数据来源: OVID

摘要:

Mucormycosis is a rare opportunistic infection usually associated with diabetes mellitus, hematologic malignancy, renal failure, or immunosuppression. Pulmonary involvement is the second most common presentation after rhinocerebral disease and carries a high mortality rate. Pulmonary mucormycosis has been sparsely reported in the literature. We present 2 cases of pulmonary mucormycosis diagnosed during life by histologic examination, with culture confirmation in 1 case. One case occurred in an immunosuppressed patient after heart and kidney transplantation. The other patient had a history of &bgr;-thalassemia major and splenectomy and had developed pulmonary mucormycosis during deferoxamine therapy, an uncommon risk factor. Both patients were treated with liposomal amphotericin B and surgical resection. One survived after this severe infection and the other died, presumably as a result of disseminated mucormycosis.

ISSN:1082-9784    

出版商:OVID    

年代:2003

数据来源: OVID