摘要:

Background: Lobaplatin, D-19466, 1,2-diaminomethyl cyclo-butane ρlatinum(II)lactate, is a new, water-soluble platinum complex which we expected would have a better therapeutic index than either cisplatin or carboplatin, since various murine and human tumor models had previously indicated effectiveness. Furthermore, a phase I study demonstrated that Lobaplatin was successful in the treatment of bronchogenic carcinomas. Patients and Methods: A total of 39 patients with inoperable advanced non-small-cell lung cancer (NSCLC), previously untreated by chemotherapy or radiotherapy, were included to receive Lobaplatin in a dose of 50 mg/m2 once every 4 weeks as a single bolus injection. Results: Of the 39 patients included, 33 were evaluable for response according to protocol. There were no complete remissions, and only 1 patient (3%) had a partial response. Most of the patients showed no change (54.5%), with the time to progression ranging between 8 and 28+ weeks. The data of 38 patients were used for the toxicity analysis. Nausea and vomiting were the leading clinical problems in nonhematological toxicity and appeared in 27 (71%) patients (in 18% of patients with WHO grade III). Regarding hematological toxicity, the leading problem was thrombocytopenia, with WHO grades III and IV in 6 and 5 patients, respectively. Conclusion: Lobaplatin was well tolerated when applied as a 50 mg/m2 single bolus intravenously in 4-week intervals. However, regarding its effectiveness, our phase II study found it to be only marginally effective in the dose and schedule used. Therefore, our results provide no support for further use of this treatment plan in patients with NSCLC

ISSN:0378-584X    

DOI:10.1159/000218806

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

摘要:

Background: Aim of the study was the biological characterization of melanoma metastases. Material and Methods: 27 patients with metastatic malignant melanoma (MM) were examined with PET and the radiotracers 18F-2-deoxy-D-glucose (FDG) and lsO-labeled water to determine metabolism and perfusion of the metastases. Results: The PET-FDG scans 60 min post injectionem (p. i.) showed a higher FDG accumulation in the metastases in comparison to normal tissue. No significant difference was noted in the perfusion of the metastases as measured with 150-labeled water in comparison to normal tissue. Therefore, perfusion is not adequate for tumor differentiation. There was no correlation between the FDG uptake values 60 min p. i. and the perfusion values 5 min p. i. of the metastases (r = 0.2577). No correlation resulted from the FDG uptake values and the period between MM diagnosis and death (r =-0.468) and the period between PET examination and death (r = 0.0427). Furthermore, we were able to distinguish between two main groups differing in the primary tumor type: nodular melanoma (MM) or superficial spreading melanoma (SSM) followed from all patient data. The FDG uptake values were compared and showed a distinct higher uptake value of NM metastases in comparison to SSM metastases. Finally the comparison of functional PET data to clinical data showed a high positive value in differentiation of malignant tissue and normal tissue. Conclusion: The radioactively labeled tracer 2-deoxy-D-glucose is an important substance for primary tumor diagnosis as well as for differentiation of malignant processes and normal tissue. The clinical value of PET for the optimization of tumor diagnosis, tumor staging as well as for therapy monitoring must be evaluated in a larger number of patients.

ISSN:0378-584X    

DOI:10.1159/000218807

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

摘要:

Background: Isolated axillary lymph node metastases in women without an obvious clinical primary site most frequently originate from the ipsilateral breast and are repeatedly described as occult breast carcinoma. If no primary tumor site can be detected within the whole observation period, ectopic breast carcinoma can be assumed, originating from heterotopic glandular tissue or breast tissue in the axillary fat, extending from the axillary part of the breast. Case Reports: Between 1988 and 1995 we examined and followed up 5 patients with carcinomas found in axillary lymph nodes without clinically detected primary sites. The treatment consisted of 2 local excisions, 3 axillary dissections with 1 limited resection and 1 biopsy of a mammographically suspicious quadrant. In neither case a primary carcinoma was found. Hormone receptor analysis was negative in 3 patients and positive for estrogen in 1 patient. One patient received local radiation, 2 patients were locally radiated in combination with either systemic chemo- or hormonal therapy, the 4th patient received systemic hormonal therapy with tamoxifen over 15 months, and the 5th patient received no additional therapy. Three patients have no evidence of disease at the most recent follow-up 1.5-7 years after diagnosis, 1 patient relapsed locally twice (2 and 27 months after diagnosis) and developed bone metastases, and 1 patient showed relapse at a local site 18 months after diagnosis. Conclusion: The case reports presented indicate that ectopic breast cancer might be a rare variant and should be differentiated from occult breast cancer with lymph node metastases or other primary tumors of the axillary tissue, for example, the rare sweat gland carcinoma. On the assumption of an ectopic breast tumor, axillary dissection should be combined with local irradiation and/or hormonal chemotherapeutic treatment, primary resection of the breast seems to be unnecessary.

ISSN:0378-584X    

DOI:10.1159/000218808

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

ISSN:0378-584X    

DOI:10.1159/000218809

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

ISSN:0378-584X    

DOI:10.1159/000218810

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

ISSN:0378-584X    

DOI:10.1159/000218811

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

ISSN:0378-584X    

DOI:10.1159/000218812

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

ISSN:0378-584X    

DOI:10.1159/000218813

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger

ISSN:0378-584X    

DOI:10.1159/000218814

出版商:S. Karger GmbH    

年代:1996

数据来源: Karger