摘要:

Herpes simplex virus types land 2 specific immune sera, sera from convalescent and healthy humans, and bovine herpes mammillitis virus-specific hyperimmune sera showed cross-neutralization with the heterologous viruses. The antigenic relationship of these herpes viruses was confirmed with complement fixation, immunodiffusion and immunofluorescence tests. Bovine herpes mammillitis infection of test animals protected them against a fatal herpes simplex virus infection. The DNA of the bovine herpes mammillitis virus (63% guanadine + cytosine; G + C) shared about 14% base sequence homology with that of herpes simplex virus type 1 (66% G + C), whereas the genetic relatedness with the infectious bovine rhinotracheitis and pseudorabies virus was less than 8%.

ISSN:0300-5526    

DOI:10.1159/000149398

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Two degenerative diseases of the central nervous system of man, kuru and Creutzfeldt-Jakob disease, were transmitted to marmoset monkeys. Kuru was passed serially, with decrease in the latent periods.

ISSN:0300-5526    

DOI:10.1159/000149399

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Three poliovirus mutants able to form plaques at 37° but not at 33.5° (i.e. cold-sensitive, or cs) were isolated from a mutagenized cs+ stock. Their biochemical lesion has not been define

ISSN:0300-5526    

DOI:10.1159/000149400

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Out of five complementation groups of vesicular stomatitis virus (VSV) type Indiana, each represented by two temperature-sensitive (ts) mutants, only representatives of group V showed genetic complementation by avian myeloblastosis virus Pseudotypes (AMV); the VSV (AMV) appeared among the progeny. Thermolabile (tl) mutants with apparently defective glycoprotein were phenotypically stabilized by growth in the presence of AMV, but a tl mutant with a defect in some other structural protein was not. Mutants with a tl glycoprotein and a ts defect corresponding to complementation group I were phenotypically stabilized by growth in the presence of AMV, but did not show genetic complementation by AMV.

ISSN:0300-5526    

DOI:10.1159/000149401

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Some rifamycin derivatives are strong inhibitors of DNA polymerase of RNA tumor viruses. However, when this activity is assayed in intact virions, in the presence of limiting concentrations of detergent, some concentrations of these drugs stimulate enzyme activity. Activation of the polymerase was achieved even in the absence of detergent in the presence of appropriate concentrations of these antibiotics. This property seems to be restricted to rifamycin derivatives possessing bulky non-polar side chains which give the molecule a ‘detergent-like’ character. It is not clear whether this property is also responsible for inhibition of the viral polymer

ISSN:0300-5526    

DOI:10.1159/000149402

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Five patients with malignant tumors were injected intravenously (i.v.) with the MP strain of lymphocytic choriomeningitis (LCM) virus. During the course of the subsequent infection, they developed leukopenia, particularly lymphopenia. Phytohemagglutinin (PHA) responses of peripheral blood lymphocytes were severely depressed during the pyretic phase of their illness and slowly recovered over 4–6 weeks. Survival of unstimulated lymphocytes in culture was depressed in parallel with the decline in PHA responses. In vitro addition of infective MP virus to cultures of lymphocytes from healthy donors produced neither depression in PHA response nor change in survival of unstimulated lymphocytes. It was concluded that the fall in PHA transformability of the patients’ lymphocytes was largely a result of a generalized cytotoxic action by the virus on lymphoid tissue in vivo. The extent of this depression was probably magnified by the more rapid recovery of PHA-unresponsive B lymphocytes compared with the slower return in numbers of long-lived PHA-responsive T lymphocy

ISSN:0300-5526    

DOI:10.1159/000149403

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

By measuring the binding of 125I-labeled antiviral antibody to virus-infected cells that had been fixed with acetone as compared to infected but unfixed cells, it was possible to detect and estimate the relative amounts of viral antigens on the surface and within the cytoplasm of infected cells.

ISSN:0300-5526    

DOI:10.1159/000149404

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Carboxymethylation of mercaptoethanol-reduced human leukocyte interferon (IF) destroyed its antiviral activity and antigenicity; both seem to be dependent upon the integrity of at least one disulfide bond.

ISSN:0300-5526    

DOI:10.1159/000149405

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Crystallographic analysis of adeno-virus type 5 crystalline patterns within KB cell nuclei revealed that the crystals belonged to the face centered cubic system, with four asymmetric units (viz. four virions) per unit cell. From the crystallographic data thus obtained, a three-dimensional model was reconstructed, from which a plausible mechanism for capsid interactions was inferred.

ISSN:0300-5526    

DOI:10.1159/000149406

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0300-5526    

DOI:10.1159/000149407

出版商:S. Karger AG    

年代:1973

数据来源: Karger