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21. |
Embolization of Basal Ganglia and Thalamic Arteriovenous Malformations |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 997-998
Gerard,
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ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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22. |
Spinal Dural Arteriovenous Fistulae Draining to the Anterior Spinal Vein: Angiographic Diagnosis |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 999-1003
Yasunari,
Niimi Avi,
Setton Alex,
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摘要:
OBJECTIVE:To describe and present atypical spinal dural arteriovenous fistulae (SDAVFs) that drain into the anterior spinal vein (ASV) and thus cause some degree of difficulty in differentiating the anterior spinal artery from the ASV.METHODS:A retrospective review of 80 selective spinal angiography procedures (with or without endovascular treatment) performed on SDAVFs since 1980 identified three cases in which the venous drainage was into a dilated ASV via a radicular vein. The patients included two men and one woman, ranging in age from 55 to 82 years (mean age, 71 yr), all of whom presented with mild to severe progressive paraparesis and sensory disturbance.RESULTS:The appearance of the venous drainage mimicked that of the usual hairpin configuration of the radiculomedullary artery and therefore caused diagnostic difficulty. There are no characteristic clinical features that differentiate this form of SDAVF from the usual type of SDAVF. The angiographic criteria for identification of the ASV draining an SDAVF include the demonstration of the branching of the ASV and its drainage into the epidural vein, opacification of other medullary veins connected with the ASV, recognition of distortion of the hairpin shape, and the identification of the anterior spinal artery at the segment where the ASV is opacified. Two patients were treated with embolization and one with surgery. All patients improved after the treatment.CONCLUSION:Before performing endovascular treatment, thorough spinal angiography with an appropriate field of view must be performed to identify this unusual type of SDAVF.
ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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23. |
Spinal Dural Arteriovenous Fistulae Draining to the Anterior Spinal Vein: Angiographic Diagnosis |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1003-1004
Paul,
Detwiler Randall,
Porter Robert,
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ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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24. |
Congress of Neurological Surgeons/American Association of Neurological Surgeons Joint Section Chairmen |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1004-1004
&NA;,
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ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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25. |
Chiari I Malformation Redefined: Clinical and Radiographic Findings for 364 Symptomatic Patients |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1005-1017
Thomas Milhorat,
Mike Chou,
Elizabeth Trinidad,
Roger Kula,
Menachem Mandell,
Chantelle Wolpert,
Marcy Speer,
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摘要:
OBJECTIVE:Chiari malformations are regarded as a pathological continuum of hindbrain maldevelopments characterized by downward herniation of the cerebellar tonsils. The Chiari I malformation (CMI) is defined as tonsillar herniation of at least 3 to 5 mm below the foramen magnum. Increased detection of CMI has emphasized the need for more information regarding the clinical features of the disorder.METHODS:We examined a prospective cohort of 364 symptomatic patients. All patients underwent magnetic resonance imaging of the head and spine, and some were evaluated using CINE-magnetic resonance imaging and other neurodiagnostic tests. For 50 patients and 50 age- and gender-matched control subjects, the volume of the posterior cranial fossa was calculated by the Cavalieri method. The families of 21 patients participated in a study of familial aggregation.RESULTS:There were 275 female and 89 male patients. The age of onset was 24.9 ± 15.8 years (mean ± standard deviation), and 89 patients (24%) cited trauma as the precipitating event. Common associated problems included syringomyelia (65%), scoliosis (42%), and basilar invagination (12%). Forty-three patients (12%) reported positive family histories of CMI or syringomyelia. Pedigrees for 21 families showed patterns consistent with autosomal dominant or recessive inheritance. The clinical syndrome of CMI was found to consist of the following: 1) headaches, 2) pseudotumor-like episodes, 3) a Meniere's disease-like syndrome, 4) lower cranial nerve signs, and 5) spinal cord disturbances in the absence of syringomyelia. The most consistent magnetic resonance imaging findings were obliteration of the retrocerebellar cerebrospinal fluid spaces (364 patients), tonsillar herniation of at least 5 mm (332 patients), and varying degrees of cranial base dysplasia. Volumetric calculations for the posterior cranial fossa revealed a significant reduction of total volume (mean, 13.4 ml) and a 40% reduction of cerebrospinal fluid volume (mean, 10.8 ml), with normal brain volume.CONCLUSION:These data support accumulating evidence that CMI is a disorder of the para-axial mesoderm that is characterized by underdevelopment of the posterior cranial fossa and overcrowding of the normally developed hindbrain. Tonsillar herniation of less than 5 mm does not exclude the diagnosis. Clinical manifestations of CMI seem to be related to cerebrospinal fluid disturbances (which are responsible for headaches, pseudotumor-like episodes, endolymphatic hydrops, syringomyelia, and hydrocephalus) and direct compression of nervous tissue. The demonstration of familial aggregation suggests a genetic component of transmission.
ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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26. |
CNS/AANS Subspecialty Fellowship Directory |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1017-1017
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ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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27. |
Contemporary Management of Spinal Osteomyelitis |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1018-1025
Ali,
Rezai Henry,
Woo Thomas,
Errico Paul,
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摘要:
OBJECTIVE:We review the results of treatment of a series of patients with spinal osteomyelitis, to formulate a systematic and comprehensive approach to the management of this disease in light of recent technical and conceptual advances in imaging, spinal biomechanics, and internal fixation.METHODS:We retrospectively reviewed the records for 57 consecutive patients with pyogenic spinal osteomyelitis who were treated between June 1987 and June 1995. Pain and weakness were the most common presenting symptoms. The mean duration of symptoms at the time of diagnosis was 10.6 weeks. Surgical indications included the presence or development of motor deficits with epidural compression and/or localized kyphotic deformities or the failure of medical therapy.RESULTS:Thirty-three patients underwent surgery as their initial treatment. Six additional patients experienced medical therapy failure and received subsequent surgical treatment. Seventeen patients were treated using an anterior approach only, 13 were treated using a posterior approach only, and 9 were treated using a combined anterior and posterior approach. After a minimal follow-up period of 24 months, 93% of the surgically treated patients showed neurological improvement or were neurologically intact, with a mean 16-degree decrease in localized kyphotic deformities and with solid bony fusion and resolution of pain for all patients.CONCLUSION:Early surgical decompression results in rapid improvement of neurological deficits, decreases in kyphotic deformities, and stabilization with bony fusion. The presence of active infection does not preclude the use of internal fixation. Nonsurgical management is indicated for patients with minimal or no neurological deficits and the absence of significant localized kyphotic deformities. However, 25% of patients who were initially treated nonsurgically experienced medical therapy failure and underwent surgical treatment.
ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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28. |
Contemporary Management of Spinal Osteomyelitis |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1025-1026
Frederick,
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ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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29. |
Contemporary Management of Spinal Osteomyelitis |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1026-1026
Richard,
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ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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30. |
Pathogenesis and Pharmacological Strategies for Mitigating Secondary Damage in Acute Spinal Cord Injury |
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Neurosurgery,
Volume 44,
Issue 5,
1999,
Page 1027-1039
Arun,
Amar Michael,
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摘要:
OBJECTIVE:Experimental models and clinical observations of acute spinal cord injury (SCI) support the concepts of primary and secondary injury, in which the initial mechanical insult is succeeded by a series of deleterious events that promote progressive tissue damage and ischemia. Whereas the primary injury is fated by the circumstances of the trauma, the outcome of the secondary injury may be amenable to therapeutic modulation. This article reviews the pathogenetic determinants of these two phases of injury and summarizes the pharmacological manipulations that may restore neurological function after SCI.METHODS:Experimental models of SCI and their inherent limitations in simulating human SCI are surveyed. The pathogenesis of primary and secondary injury, as well as the theoretical bases of neurological recovery, are examined in detail. The effects of glucocorticoids, lazeroids, gangliosides, opiate antagonists, calcium channel blockers, glutamate receptor antagonists, antioxidants, free radical scavengers, and other pharmacological agents in both animal models and human trials are summarized. Practical limitations to inducing neural regeneration are also addressed.RESULTS:The molecular events that mediate the pathogenesis of SCI are logical targets for pharmacological manipulation and include glutamate accumulation, aberrant calcium fluxes, free radical formation, lipid peroxidation, and generation of arachidonic acid metabolites. Enhancement of neural regeneration and plasticity comprise other possible strategies.CONCLUSION:Pharmacological agents must be given within a narrow window of opportunity to be effective. Although many therapeutic agents show potential promise in animal models, only methylprednisolone has been shown in large, randomized, double-blinded human studies to enhance the functional recovery of neural elements after acute SCI. Future therapy is likely to involve various combinations of these agents.
ISSN:0148-396X
出版商:OVID
年代:1999
数据来源: OVID
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