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11. |
Concentrations of Lead, Magnesium, Calcium, Zinc and Cadmium in Twenty Rabbit Tissues after Exposure to Low Lead Doses and Atherogenic Diet |
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Annals of Nutrition and Metabolism,
Volume 27,
Issue 6,
1983,
Page 531-541
Michelle Speich,
Claire Métayer,
Pierre Arnaud,
Van Goc Nguyen,
Henri-Louis Boiteau,
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摘要:
Four groups of 6 rabbits were subjected to the following diets for 25 weeks: I (controls), II (water with 9.66 µmol/l of lead), III (atherogenic) and IV (atherogenic + 9.66 µmol/l of lead). Lead, magnesium, calcium, zinc and cadmium were then analyzed in 20 dry tissues. At the level of the arteries, veins and skin a tendency was observed toward increased lead concentration in rabbits of groups II and IV, elevated calcium levels in groups III and IV (a tenfold increase of calcium in the aortas), and a higher concentration of cadmium in animals of group II. There was a significant reduction in lead and magnesium concentrations in the liver of animals in groups III and IV because of fibrosis and overabundance of fatty liver cells. The lead level in the liver of animals in group II had slightly increased. Lead concentrations were higher in the kidneys and spleen in groups II and IV. Cadmium levels were significantly lower in the liver, kidneys, adrenal glands and spleen of animals in groups III and IV, whereas in group II they were particularly increased in the liver and kidneys. Very little significant interaction between the two diets was noted. Rabbits in groups III and IV showed notable histopathological alterations in aorta, carotid and femoral arteries, left ventricle and liver. Extrapolation from rabbit to man would be inadvisabl
ISSN:0250-6807
DOI:10.1159/000176730
出版商:S. Karger AG
年代:1983
数据来源: Karger
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12. |
Author Index, Vol. 27, 1983 |
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Annals of Nutrition and Metabolism,
Volume 27,
Issue 6,
1983,
Page 542-543
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ISSN:0250-6807
DOI:10.1159/000176731
出版商:S. Karger AG
年代:1983
数据来源: Karger
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13. |
Subject Index, Vol. 27, 1983 |
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Annals of Nutrition and Metabolism,
Volume 27,
Issue 6,
1983,
Page 544-546
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ISSN:0250-6807
DOI:10.1159/000176732
出版商:S. Karger AG
年代:1983
数据来源: Karger
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14. |
Contents, Vol. 27, 1983 |
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Annals of Nutrition and Metabolism,
Volume 27,
Issue 6,
1983,
Page -
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ISSN:0250-6807
DOI:10.1159/000176719
出版商:S. Karger AG
年代:1983
数据来源: Karger
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