摘要:

Fifty adult female Swiss albino mice were injected with either 1.11 mg/kg body weight pyridoxine or saline, subsequently they were all submitted to an immobilization stress with a complete fast for 17 h. At the end of this period, the animals were sacrificed, the gastric mucosa was dissected for ulcer count, and brain noradrenaline, dopamine and serotonin were determined by liquid chromatography. In addition, 26 non stressed mice were used as controls, 16 of them being fed at libitum and 10 submitted to the same fasting period as the first two groups. In the stressed animals, the average number of gastric ulcers per mouse was twice as large in the saline-treated group than in the pyridoxine-treated group (p < 0.05). With a single exception, no ulcer was found in the non stressed controls. Brain norepinephrine content was almost identical in fasting controls and in stressed mice treated with pyridoxine; in the stressed animals treated with saline, the average norepinephrine content was higher by 15 % and in the fed controls lower by 11 % than in the two preceding groups. Pyridoxine treatment entailed a very significant reduction (p < 0.002) of norepinephrine variability, mainly due to the absence of high values (≧ 750 ng/g of fresh brain) which occurred only in the saline-treated group. Similar results were yielded for brain dopamine. No variations were observed for brain serotonin. These results suggest the antistress effect of pyridoxin

ISSN:0250-6807    

DOI:10.1159/000177735

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Seven consecutive day food records were assessed in 224 free-living adult volunteers to (1) identify the smallest number of days, and which days of the week, would provide most of the information about dietary fat and cholesterol intake (assessed by B score) and (2) whether a complex mathematical formula for weighting certain days was required to achieve reasonable validity. A factor analytic approach was used to identify 3- and 4-day sets. The correlations with the 7-day average B score ranged from 0.95 for the best 4-day (Saturday through Tuesday) average B score to 0.91 for the best 3-day (Sunday through Tuesday) average B score. Simple averaging (no weighting) was found to be adequate to achieve this level of validity.

ISSN:0250-6807    

DOI:10.1159/000177736

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

The administration of the repartitioning agent metaproterenol, with affinity for β1 and β2-receptors, induced marked increases in gastrocnemius muscle and heart weights. The renal loss of essential amino acids was reduced in animals treated with β-adrenergic agonists and a significant reduction in total serum amino acids was found as well. The assessment of urinary 3-methylhistidine suggests, that those changes were accompanied by a lower myofíbrillar protein breakdown, while hydroxyproline output was increased as an indirect index of collagen turno

ISSN:0250-6807    

DOI:10.1159/000177737

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

The effect of a weight reduction regimen, consisting of a protein-sparing modified fast and an exercise program, on the fatty acid composition of serum phospholipids and cholesterol esters of obese women, is described. In phospholipids, this treatment did not induce any significant change of the different fatty acid families (total saturated, monounsaturated, ω9, ω 7, ω 6 and trans-fatty acids), except for total ω 3 fatty acids which increased. Within families, individual fatty acids change however. The changes are compatible with increased Δ5 and Δ6 desaturase activity. In cholesteryl esters, significant changes occurred which are suggestive of an increase in serum of the fraction of cholesteryl esters of intracellular origin. The changes in fatty acid compositions may not be beneficial with respect to atheroscle

ISSN:0250-6807    

DOI:10.1159/000177738

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000177739

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000177740

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000177741

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000177724

出版商:S. Karger AG    

年代:1992

数据来源: Karger