摘要:

Cynomolgus monkeys (Macaca fascicularís) were fed diets containing 25% rapeseed oil (RSO), partially-hydrogenated herring oil (PHHO) or a 3:1 mixture of lard/corn oil as control (CON) for 4 months. The RSO contained approximately 25% of the fatty acids as erucic acid (cis-docos-13-enoic, 22:lw9) while the PHHO contained a similar concentration of mainly cetoleic acid (cis-docos-11-enoic, 22:lwll). The CON contained no 22:1 acids. The monkeys developed the expected myocardial lipidosis, somewhat more pronounced in the RSO than the PHHO group, but small foci of mononuclear cell infiltration, while infrequent, occurred in all three groups. Significant intergroup differences in biochemical or hematologic measurements of serum constituents were an increase in serum cholesterol concentration in the RSO group and an increase in serum glutamic oxaloacetic transaminase activity in both RSO and PHHO groups at certain intervals. The shorter proportion of M. fascicularis life span represented by this experiment may account for the absence of clear intergroup differences such as are reported in rats used in similar studies.

ISSN:0250-6807    

DOI:10.1159/000176217

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

In order to study the effects of a dietary rapeseed protein concentrate (RPC) on tocopherol and zinc levels in serum, liver and tibia, female rats were fed a tocopherol-reduced diet for a 3-week period and were then transferred to either of a RPC diet or a control diet containing casein at 20% levels of protein. No unfavourable effects on food intakes or weight gains were recorded. The serum zinc content of the RPC group was slightly reduced and the serum tocopherol values significantly lowered in comparison to the control group. Zinc and tocopherol contents of the livers were not changed. Precipitation of sera by dextran sulphate in the presence of calcium ions indicated a reduced level of low density lipoproteins in rats fed RPC diet. In a second experiment, male and female rats were fed diets containing 10% of protein derived either from RPC or casein. Low zinc contents of tibiae indicated a low biological availability of the zinc present in the RPC diet. Rats on RPC diet also showed reduced levels of tocopherol in serum. Despite a lowered zinc status in rats fed RPC diet there was no reduction in food intake, weight gain or growth of tibia in these groups.

ISSN:0250-6807    

DOI:10.1159/000176218

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The development of pancreatic tissue (fresh weight, total proteins, RNA and DNA) and of the level of pancreatic enzymes (trypsin, chymotrypsin, lipase and amylase) of the piglet has been followed from birth to the age of 8 weeks in 10 animals at each of 7 stages. There was an increase with age and body weight of the total fresh weight of the exocrine pancreas. From birth until 4 weeks the development of the pancreatic gland was due to hyperplasia; from the 4th week till the 8th week of age, it was due both to hyperplasia and hypertrophy. There was a specific period, at the age of 3–4 weeks, from which total enzymatic activities markedly increased. Furthermore, from the 4th week of age there was a rise in the intake of total dietary proteins, fat and carbohydrates, due to the intake of solid food.

ISSN:0250-6807    

DOI:10.1159/000176219

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The changes with age of intestinal mucosa, protein, lactase, maltase and sucrase were followed in the piglet between day 105 of gestation and 8 weeks after birth. Lactase and maltase activities appeared during fetal life in the whole of the small intestine. Activity of sucrase was recorded after the 1st postnatal week. Lactase activity was high at birth and reached a maximum at 1 week (× 2.5); maltase activity which was low at birth increased to the 8th week (× 143). Activities of all enzymes were low in the duodenum; lactase was most active in the jejunum. Similar activities of maltase and sucrase were found in the two distal parts of the small intestine. Specific activity (related to protein content) of lactase reached a maximum at the end of the 1st week after birth and decreased afterwards. Specific maltase and sucrase activities were higher in the 2nd week, decreased between the 2nd and 4th week and increased afterwards (maltase) or decreased to the 6th-8fh week (sucrase).

ISSN:0250-6807    

DOI:10.1159/000300539

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000300540

出版商:S. Karger AG    

年代:1978

数据来源: Karger