摘要:

Cis-9-octadecenyl alcohol was fed as a dietary supplement to adult male rats for 7 and 14 days. At the end of these feeding intervals, lipids were extracted from brain and liver. The neutral lipids were analyzed for free and esterified long-chain alcohols and alkyl and alk-1-enyl glycerols. Total lipid phosphorus, alkyl acyl and alk-1-enyl acyl phosphoglycerides were determined in the phospholipid fraction. A marked change was observed in these lipid types in the liver, but not in the brain. In liver the free and esterified long-chain alcohols increased threefold following feeding of the dietary supplement. Feeding cis-9-octadecenyl alcohol had no effect on the neutral alkoxy lipids of liver but resulted in an approximately three- to eightfold increase in the ionic alkoxy lipids.

ISSN:0250-6807    

DOI:10.1159/000175592

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Two groups of men, 40 through 59 years old, from two rural areas of Italy (one in the north and one in the centre) were subjects of dietary surveys on three occasions over 10 years, using the individual weighing technique. Over the 10 years, changes in the consumption of some foods were observed; these were most striking in respect to cereals and legumes, which decreased, and to animal protein and fats, which increased. The decrease of energy was much greater than expected (partly explained by the current mechanization in agriculture in Italy). In one area a low intake of riboflavin was observed, but otherwise the diets could be considered to be nutritionally good. There was no correlation between some dietary variables and anthropometric and blood lipid data, as observed previously. This was probably because the population groups examined were practically homogeneous in regard to habits.

ISSN:0250-6807    

DOI:10.1159/000175593

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The protein metabolism of rats bearing bilateral lesions in the ventromedial area of hypothalamus (VMH) was studied in nitrogen balance experiments employing high protein and high fat diets. The catabolic effect of VMH destruction was to a great extent counterbalanced by increased protein intake. This indicates that increased amino acid catabolism, rather than impaired mechanisms for protein synthesis, is responsible for the poor nitrogen retention of VMH-lesioned rats fed normal amounts of protein. A trend of increasing nitrogen excretion with increasing dietary fat was found when the caloric intake of VMH-lesioned animals was elevated by substitution of dietary carbohydrates with fat. Persistent liponeogenesis in spite of the high fat intake, is suggested as a possible explanation for this observation.

ISSN:0250-6807    

DOI:10.1159/000175594

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The effect of two bulk-forming appetite depressants, methylcellulose and gum guar, on food intake has been studied in 11 (4 male, 7 female) healthy volunteers – 3 of whom were overweight. 10 g of active ingredient were given in two equal doses daily for periods of 1 week for each agent. Individually weighed dietary intakes were obtained over four consecutive weeks; the first and third weeks were without medication. Both gum guar and methylcellulose were equally effective in reducing appetite by 10

ISSN:0250-6807    

DOI:10.1159/000175595

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Giving weanling rats a low protein diet for 56 days retarded the growth of the brain, whereas giving isoenergetic amounts of a high protein diet did not. The low protein diet resulted in higher concentrations of aspartic acid, glycine, alanine and histidine in the plasma and of glycine and histidine in the brain. The concentration of methionine was unchanged in the plasma, but raised in the brain. Isoenergetic amounts of the high protein diet did not change the concentration of plasma amino acids, but resulted in some changes in brain amino acids. On rehabilitation the plasma and brain amino acids of the low protein animals returned to normal.

ISSN:0250-6807    

DOI:10.1159/000175596

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The activity of metabolic pathways involved in the formation and utilization of phosphoribosylpyrophosphate (PRPP) was studied in the erythrocytes of 34 patients with idiopathic metabolic gout. The activities of the oxidative pentose shunt, of the hypoxanthine-guanine and adenine phosphoribosyltransferases (HGPRT, APRT) and of PRPP synthetase, as well as the rates of PRPP generation and of adenine incorporation into nucleotides were found to be normal in the erythrocytes of all these patients. Four patients with metabolic gout due to enzymatic abnormalities, two relatives with partial deficiency of HGPRT and two relatives with mutant feedback-resistant PRPP synthetase, were studied for comparison. The significance of the results is discussed in relation to postulated mechanisms for purine overproduction in metabolic gout.

ISSN:0250-6807    

DOI:10.1159/000175597

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000175598

出版商:S. Karger AG    

年代:1975

数据来源: Karger