摘要:

A number of parameters of galactose metabolism was studied in 28 patients with cataract and 17 normal subjects. Erythrocyte glutathione reductase activity was employed to evaluate their riboflavin nutritional status. Patients with cataract had significantly lower activity of glutathione reductase in erythrocytes as compared to controls. While these patients exhibited abnormal galactos tolerance to galactose load, the activities of galactokinase in erythrocytes and transferase in blood samples were normal. Although administration of riboflavin improved the activity of erythrocyte glutathione reductase, it failed to correct the abnormal galactose tolerance in cataract patients. The impaired tolerance to oral galactose load, observed in patients with cataract, was not associated with either reduced uptake of 14C galactose by erythrocytes or lower excretion of the sugar through kidney.

ISSN:0250-6807    

DOI:10.1159/000175513

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Feeding of defatted millet (Sorghum vulgarie) at different protein levels to rats for 6 weeks caused significant increases in liver total lipids, cholesterol, fatty acids, triglycerides (TG), phospholipids and its two major fractions PC and PE, as compared to the controls. Plasma triglycerides in millet protein fed rats were not reduced. Incorporation of palmitate-1-14C into liver TG, PC and PE of millet protein fed rats was significantly greater than the controls. The incorporation of palmitate-1-14C into plasma TG and into liver FC and EC of rats fed millet protein was equal to or slightly increased as compared to controls. These results show that the accumulation of TG in liver of rats fed millet at different protein levels results from their greatly enhanced synthesis and unimpaired secretion into plasma.

ISSN:0250-6807    

DOI:10.1159/000175514

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Single cell proteins prepared from yeast or bacterial cells grown on a chemically pure hydrocarbon fraction were fed to male and female rats either as the sole sources of protein at a dietary protein level of 20 % or as supplements to a commercial stock diet at two levels providing 15 and 25 %, respectively, of single cell protein. Two control diets were used. One was a synthetic casein containing diet and the other a commercial stock diet. With the exception of an increased occurrence of renal calcification yeast diets did not affect mortality, general condition or behaviour of the animals. Yeast as the sole source of protein produced a lower growth rate than the casein and stock diets. This could be due to a deficit in sulfur-containing amino acids. Adverse effects on the health of rats fed bacterial single cell protein as the sole source of protein were observed. These were arrested growth, weight losses, bleedings at nose and eyes and increased mortality. At the histological examination of organs from these rats, severe pyelonephritis, nephrocalcinosis and testicular atrophies were seen. Blood from these rats showed a changed neutrophil: lymphocyte ratio.

ISSN:0250-6807    

DOI:10.1159/000175515

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A study was made of carbohydrate digestibility and weight gain response in rats fed sucrose, glucose or fructose at varying levels in the diet. In a long-term experiment with older rats, sucrose-fed animals attained a greater mature weight than glucose and fructose-fed animals. In a digestibility study of shorter duration, animals fed sucrose and glucose diets had similar weight gains whereas fructose-fed animals showed a diminished weight gain response at higher levels of fructose in the diet. The digestible energy of glucose was observed to be significantly lower than that for either sucrose or fructose. Whereas the lower digestible energy of glucose may account for the lower weight gain on high glucose diets, a similar explanation is not valid for the response to fructose feeding. It would appear that an effect other than lowered feed intake or decreased digestibility is the cause of the lower weight gains observed on high fructose diets.

ISSN:0250-6807    

DOI:10.1159/000175516

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A study was made of weight gains and carcass compositions in response to dietary sucrose, glucose, fructose, and corn starch at two dietary levels (40 and 60 %). Protein in the diets was either minimally adequate (12 %) or in excess of the requirement (18 %). At both carbohydrate and protein levels, sucrose-fed rats showed significantly greater weight gains than those animals receiving the other carbohydrates. At the 40-percent level, corn starch-fed animals gained more weight than animals receiving either glucose or fructose. At the 60-percent level, animals presented with fructose gained less weight than animals receiving the other carbohydrates. The animals receiving sucrose at both dietary levels had more carcass fat than those receiving either glucose or corn starch, and more carcass fat than those receiving fructose at the 60-percent level. An inverse relationship existed between carcass fat and carcass protein when both were expressed as a percentage of carcass dry weight. The fructose diets had protein retention values intermediate to those seen on the other diets. Protein retention on the sucrose diets was at least as high or higher than that on the starch diets. The results are consistent with the concept that different dietary carbohydrates elicit differing metabolic responses as measured by both weight gains and carcass analyses.

ISSN:0250-6807    

DOI:10.1159/000175517

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Methionine metabolism was studied in a group of subjects having clinical signs and symptoms of peripheral neuropathy. Following a load of methionine, these subjects excreted higher amounts of cystathionine, and the ratio of cystathionine/ cysteine sulfinic acid was elevated suggesting a block in the conversion of cystathionine to cysteine sulfinic acid. The load return of methionine as cystathionine was significantly more. These results indicate that the activity of enzyme cystathionase, a pyridoxal-dependant enzyme, is low in pyridoxine deficiency. With pyridoxine therapy, there was a significant improvement in the clinical status, and the biochemical abnormalities were corrected.

ISSN:0250-6807    

DOI:10.1159/000175518

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000175519

出版商:S. Karger AG    

年代:1974

数据来源: Karger