摘要:

The role of iron was evaluated in pigs that died suddenly of microangiopathy (mulberry heart disease) characterized by myocardial and endothelial cell damage and capillary microthrombosis. Myocardial iron concentration (mean ± SD) in pigs with microangiopathy (416 ± 87 µg/g, dry weight) was significantly (p < 0.001) higher than in pigs with other diseases (294 ± 93 µg/g) and in healthy slaughter pigs (231 ± 43 µg/g). Similarly, hepatic iron concentration in pigs with microangiopathy (1,211 ± 254 µg/g) was significantly (p < 0.001) higher than in pigs with other diseases (873 ± 296 µg/g) and in healthy slaughter pigs (831 ± 284 µg/g). The results indicate that myocardial and hepatic iron concentration was increased in pigs with microangiopathy. Increased myocardial and hepatic iron concentration might have promoted oxidative stress in selenium-vitamin E-defïcient pigs and thus contributed to the development of oxi

ISSN:0250-6807    

DOI:10.1159/000177586

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The free amino acids of the plasma and pectoral muscle, liver and brain cytosolic SI05 supernatant obtained from 2- and 3-week-old fasted chicks, were analyzed by HPLC after deproteinization by ultrafiltration. Protein-bound amino acids were analyzed in parallel studies. A clear relationship between the free and bound tissue amino acids was apparent. Only for the gluconeogenic amino acids a close correlation was evident between the plasma and the muscle free amino acids. A relatively steady composition of the free amino acids is established early in the tissues, but in the plasma it changes significantly with age.

ISSN:0250-6807    

DOI:10.1159/000177587

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Body weight and height of Japanese boys and girls aged 12–14 years were measured to calculate the prevalence of obesity, leanness and anorexia nervosa. In boys, the prevalence of obesity as well as leanness was significantly higher in the areas where population density was lower and among the boys who attended schools with smaller numbers of pupils. In the girls, these findings were similar to the boys. On the other hand, anorexia nervosa was found in girls only more commonly in the areas with higher population density and in the larger schools. These results suggest that higher prevalence of obesity in certain subjects may be associated with increased numbers of leanness but not with anorexia nervos

ISSN:0250-6807    

DOI:10.1159/000177588

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

When adult rats are given diets high in carbohydrate and which contain insufficient energy, the rate of weight loss is not linearly related to energy intake. This non-linear relationship is seen when energy intake reduction is not severe.

ISSN:0250-6807    

DOI:10.1159/000177589

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The subjects consisted of four groups: group 1 nonambulatory patients receiving carbamazepine; group 2 ambulatory patients receiving carbamazepine; group 3 nonambulatory patients receiving no drug, and group 4 ambulatory patients receiving no drugs. The serum 25-hydroxyvitamin D (25-OH-D) concentration was significantly lower in group 1 than in all other groups. There was no difference between the groups as regards the serum 1,25-dihydroxyvitamin D or 24,25-dihydroxyvitamin D concentration. Carbamazepine treatment lowers the serum 25-OH-D concentration, and inactivity which leads to a lower degree of time spent out-of-doors and thus a low exposure to sunlight still decreases the concentration. In this study a low dietary vitamin D intake probably was an aggravating factor.

ISSN:0250-6807    

DOI:10.1159/000177590

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Young and aging rats were fed for different periods (10, 90, 180 and 365 days) diets containing 15 % of fresh or heated sobean oil. Thiobarbituric reactive substances (TBA-RS), lipofuscin, superoxide dismutase (SOD), vitamin A, vitamin E and microsomal and mitochondrial fatty acids in liver, brain and serum were measured. Heated oil diets induced significant increase of TBA-RS levels in liver, with earlier effects in aging rats and affected SOD activity in aging rats only after a long period of feeding. Circulating and stored vitamin A were reduced in both young and aging rats, with earlier effects in young animals. Serum and liver vitamin E was significantly reduced in all test groups. The results indicate that heated unsaturated oil produces reduction in the antioxidative defense system and that vitamin E status is the earliest indicator of the oxidative effect regardless of age.

ISSN:0250-6807    

DOI:10.1159/000177591

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Weanling male rats were fed a purified iron-adequate, a purified iron-deficient or a commercial diet for 12 weeks. At that time the rats were sacrificed, their hearts and livers were excised, and blood samples were taken. Heart and liver weights were recorded; organ tissue and serum samples were analyzed for Zn, Cu and Fe. Hemoglobin and hemat-ocrit values were also obtained. The iron-deficient rats grew much more slowly than controls on the iron-adequate or commercial diets. The iron-deficient rats were severely anemic and had enlarged hearts (cardiomegaly). A histopathologic examination of the hearts of all animals showed that each heart of the iron-deficient rats had lesions characteristic of cardiomyopathy by dilatation, whereas none of the hearts of the iron-adequate group or the chow controls showed any lesions at all. The iron-deficient animals had only about 25% of the hepatic iron found in the iron-adequate animals but about 5 times the hepatic copper of the latter group or the chow controls. Heart iron of the iron-deficient group was 27% of the concentration found in hearts of the iron-adequate rats; heart copper was similar in all groups. Animals on the commercial stock diet accumulated significantly more iron in their hearts than did those on the purified iron-adequate diet but not in the livers. There was also a direct correlation of heart iron or heart zinc with log concentrations of dietary iron and consequently a direct correlation between heart iron and zinc concentrations.

ISSN:0250-6807    

DOI:10.1159/000177592

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Recovery from Mg deficiency was studied in rats given an organic source of Mg derived from yeast (Saccharomyces cerevisiae) cultured in an Mg gluconate-enriched medium, as the only source of Mg. Magnesium was given either at a rate above the RDA or as a supplement to the regular laboratory diet at the rate of 70 mg Mg/100 g food, of which 40 mg Mg was in the form of MgCO3 and the remaining 30 mg Mg was in the form of the organic product under study. The results showed a good degree of digestive and metabolic utilization of the organic compound, which led to the recovery of normal Mg levels in blood and bone by the end of the 1st week of treatment, and in muscle by the 3rd week of treatment. Muscle Mg content appears to be a good indicator of deficiency. Supplementation above the RDA failed to improve recovery rates in deficient animals.

ISSN:0250-6807    

DOI:10.1159/000177593

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0250-6807    

DOI:10.1159/000177594

出版商:S. Karger AG    

年代:1990

数据来源: Karger