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1. |
The ISI Impact Factor and Rankings: 2001 |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 431-431
Judith Sondheimer,
Jehan-Francois Desjeux,
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ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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2. |
Improving Nutritional Support in Chronic Lung Disease |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 432-433
Régis Hankard,
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ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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3. |
Breast-Feeding and HIV Transmission: The Jury Is Still Out |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 434-442
Anna Coutsoudis,
Nigel Rollins,
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ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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4. |
Feeding Behavior Problems in Children With Cystic Fibrosis in the UK: Prevalence and Comparison With Healthy Controls |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 443-447
Alistair Duff,
Susan Wolfe,
Corrine Dickson,
Steven Conway,
Keith Brownlee,
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摘要:
BackgroundFeeding behavior problems contribute to inadequate dietary intake for many patients with cystic fibrosis (CF). However, to establish effective intervention programs, more needs to be known about the occurrence and distribution of these difficulties. The aims of this study were to establish the prevalence and range of disruptive child behaviors (DCB) in patients with CF and the inappropriate parental responses (IPR) during mealtimes and to compare the results with those of healthy children.MethodsIn study A, parents of 108 patients (aged 1–7 years) completed a Behavioural Paediatric Feeding Assessment Scale comprising two domains: DCBs and IPRs during mealtimes. Parents rated the frequency of the behaviors and responses and identified those they considered problematic. In study B, data from the CF group (n = 69, aged 1–12 years) were compared with 69 age- and sex-matched control subjects.ResultsParents of children with CF aged 5 to 8 years recorded significantly more DCBs than those in all other age ranges. These parents also reported significantly more IPRs than did parents of children aged 9 to 12 years and 13 to 17 years. Parents of children with CF reported significantly more DCBs and IPRs than did those of the control subjects. There were significantly more problematic DCBs and IPRs in the CF group than in the control group for children aged 5 to 8 years and 9 to 12 years but not for those aged 1 to 4 years.ConclusionsParents of children with CF report more feeding behavior problems than do those of healthy control subjects. The high prevalence of feeding behavior problems in older children suggests that preventative and reactive interventions must continue throughout childhood and vary according to the child's developmental abilities.
ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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5. |
Aluminum Contamination of Parenteral Nutrition and Aluminum Loading in Children on Long-Term Parenteral Nutrition |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 448-453
Emmanuelle Advenier,
Caroline Landry,
Virginie Colomb,
Cécile Cognon,
Dominique Pradeau,
Maurice Florent,
Olivier Goulet,
Claude Ricour,
Odile Corriol,
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摘要:
BackgroundChildren who are receiving parenteral nutrition are at risk of aluminum overload, which may contribute to such side effects as osteopenic bone disease. The aim of the present study is to determine the aluminum contamination of parenteral nutrition solutions and their components, and to assess the aluminum status of children on long-term parenteral nutrition.MethodsAluminum concentrations were determined by graphite furnace absorption spectroscopy in components and in final parenteral nutrition solutions. The urinary aluminum excretion and plasma aluminum concentration were determined in 10 children on long-term parenteral nutrition.ResultsThe mean aluminum concentration in the administered parenteral nutrition solutions was 1.6 ± 0.9 &mgr;mol × l−1(mean ± standard deviation (SD)). The resulting mean aluminum daily intake of the 10 patients was 0.08 ± 0.03 &mgr;mol × kg−1× day−1.ConclusionsCompared to two previous studies performed in 1990 and in 1995 in our hospital, the aluminum contamination of parenteral nutrition solutions and the daily aluminum intake of the children seemed to decrease. However, the plasma aluminum concentration and daily urinary aluminum excretion of the children still remain above normal standards. The children had no clinical symptoms of bone disease but aluminum accumulation in tissue can not be excluded. To prevent this iatrogenic toxicity, the aluminum contamination of parenteral nutrition should be assessed regularly.
ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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6. |
Esophageal Crohn Disease in Children: A Clinical Spectrum |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 454-458
Kannan Ramaswamy,
Kevan Jacobson,
Gareth Jevon,
David Israel,
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摘要:
BackgroundThe incidence of esophageal Crohn disease (ECD) in adults ranges from 0.2% to 11.2% and in children is up to 43%. The aim of the study was to determine the clinical and endoscopic spectrum of ECD and its prevalence in our patient population.MethodsChart review of children with Crohn disease (CD). Esophageal Crohn disease was defined by accepted endoscopic and/or histologic findings.Results210 children with CD were identified; 27 of those children had ECD. Nine children presented with specific upper GI symptoms; dysphagia, heartburn, nausea, vomiting, and odynophagia. Esophagoscopy in children with upper gastrointestinal symptoms revealed deep ulcers (n = 2), aphthous ulcers (n = l), erosions (n = l), edematous nodules, (n = l) and normal mucosa (n = 4). In asymptomatic children aphthous ulcers (n = 5), erosions (n = 3), deep ulcers (n = 3), and normal looking mucosa (n = 7) were seen. Twenty children also had gastric lesions, 3 children had duodenal lesions, and 3 children had both duodenal and gastric involvement. All 27 children had evidence of ileo-colonic or colonic disease. Acid suppressive medications were given only to children with upper GI symptoms and endoscopic esophageal lesions. The mean duration of follow-up from diagnosis of CD was 3.02 years (range 2 months—11.7 years). At last follow-up review, 7 children were receiving acid suppression and no children were receiving steroids. There were no complications related to ECD.ConclusionThe prevalence of endoscopic ECD is 7.6% but as many as 17.6% of our patient population had histologic evidence of ECD. The clinical and endoscopic spectrum of ECD are highly variable and poorly correlate with each other.
ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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7. |
Gastrostomy in Infants With Neonatal Pulmonary Disease |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 459-463
D. Guimber,
L. Michaud,
L. Storme,
A. Deschildre,
D. Turck,
F. Gottrand,
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摘要:
ObjectiveTo report our experience of enteral feeding via gastrostomy in children with severe chronic neonatal lung disease, failure to thrive, and oral aversive behavior after initial hospitalization.PopulationThirteen patients were studied. All children had chronic lung disease of neonatal onset and were severely malnourished. They received enteral nutrition via a gastrostomy at a median age of 13 months (range: 8–35).ResultsZ-scores for weight-for-height increased significantly, from −3.4 to −1.9 after four months of enteral nutrition. Caloric intake increased significantly from 100% to 140% of the recommended daily allowance for age. Pulmonary status remained stable for all patients and oxygenation was normal. There was an aggravation of oral aversive behavior in 7 of the 13 children, especially those children who were ventilated and hospitalized for a long time (median duration: 195 days). The median follow-up of patients after gastrostomy was 30 months (range: 8–54) and only six patients could be weaned from enteral nutrition.ConclusionEnteral nutrition via gastrostomy is efficient, and provides the means to improve caloric intake and nutritional status. Gastrostomy is a safe and convenient technique that should be considered early in the course of treatment for infants presenting with malnutrition related to neonatal pulmonary disease.
ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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8. |
Consensus and Controversy in the Management of Pediatric Crohn Disease: An International Survey |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 464-469
Arie Levine,
Tamir Milo,
Hans Buller,
James Markowitz,
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摘要:
ObjectivesTreatment options for patients with Crohn disease (CD) have expanded, but the use of some of these options in pediatric patients remains controversial. The authors evaluate current trends in treatment and areas of consensus or controversy.MethodsAn international survey of certified pediatric gastroenterologists was conducted using an e-mail questionnaire in an attempt to evaluate management of active Crohn disease, attitudes toward four types of therapy, and prevalence of testing for osteopenia and 6-thioguanine levels.ResultsOne hundred sixty-seven physicians from the United States, Canada, Western Europe, and Israel were included. The majority of North American physicians (71%) prefer to use conventional steroids and azathioprine (AZA) before nutritional therapy or budesonide for patients with mild to moderately active disease, versus 21% of Western Europeans (P< 0.001). Western Europeans prefer nutritional therapy followed by budesonide or steroids for those with mild or moderate disease. Only 4% of North American gastroenterologists use nutritional therapy frequently versus 62% of their Western European colleagues (P< 0.001). Infliximab was thought to be effective for steroid-unresponsive disease by almost all physicians surveyed, although its efficacy as a maintenance therapy was rated higher by North American physicians than by their Western European and Israeli colleagues (P< 0.01). Bone mineral density is routinely evaluated by about 45% of physicians in Western Europe and North America.ConclusionsAttitudes toward current therapies vary significantly by region, with North Americans strongly favoring corticosteroids followed by immunomodulatory therapy, and Western Europeans favoring nutritional therapy or budesonide and the avoidance of conventional corticosteroids.
ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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9. |
Increased Prevalence of Autoimmune Diseases in First-Degree Relatives of Patients With Celiac Disease |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 470-473
Francesco Cataldo,
Vincenzo Marino,
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摘要:
BackgroundThe prevalence of autoimmune disorders is increased in patients with celiac disease (CD), and it is unknown whether their first-degree relatives also have a high risk of autoimmune disorders.MethodsTo assess the prevalence of autoimmune diseases in first-degree relatives of CD patients, the authors looked for autoimmune disorders in 225 first-degree relatives of 66 children with CD (group A) and in 232 first-degree relatives of 68 healthy children (group B). For both groups, serologic screening for CD was performed through antiendomysium (EMA) and tissue transglutaminase autoantibodies (tTGAA). EMA- and tTGAA-positive subjects were offered an intestinal biopsy. The age at onset of autoimmune diseases was also recorded in group A.ResultsThe prevalence of autoimmune disorders was significantly (P= 0.028) higher in group A (11 of 225, 4.8%) than in group B (2 of 232, 0.86%). In relatives of CD patients, the prevalence increased with age (&khgr;2for trend, 43.5;P< 0.0001). Serologic screening for CD was only positive in group A (15 of 225 subjects). An intestinal biopsy was performed in 13 of these 15 relatives (2 refused biopsy). Eleven of 13 had flat mucosa, with subclinical or silent forms of CD. The prevalence of autoimmune diseases in the EMA- and tTGAA-positive relatives of CD patients was significantly higher (3 of 15, 20%;P= 0.028; odds ratio, 6.3; 95% CI, 1/0.21–1/0.11, 4.9–7.6) than in those who were EMA and tTGAA negative (8/210, 3.8%).ConclusionsThe first-degree relatives of CD patients have an increased risk of autoimmune diseases, most likely connected with unrecognized subclinical or silent forms of CD.
ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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10. |
Longitudinal Follow-Up of Exocrine Pancreatic Function in Pancreatic Sufficient Cystic Fibrosis Patients Using the Fecal Elastase-1 Test |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 36,
Issue 4,
2003,
Page 474-478
Jaroslaw Walkowiak,
Sanda Nousia-Arvanitakis,
Christina Agguridaki,
Maria Fotoulaki,
Krystyna Strzykala,
Angeliki Balassopoulou,
Michal Witt,
Karl-Heinz Herzig,
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摘要:
BackgroundA progressive decline in pancreatic function is possible in cystic fibrosis (CF) patients with exocrine pancreatic sufficiency. The secretin–cholecystokinin test is invasive and not acceptable as a repeatable procedure for children. Steatorrhea, conversely, has low sensitivity. Therefore, the aim of the present study was to evaluate the usefulness of the noninvasive fecal elastase-1 (E1) test for the longitudinal assessment of exocrine pancreatic function (EPF) in pancreatic-sufficient (PS) CF patients.MethodsOne hundred eighty-four CF patients were included in the study. In all subjects, E1 concentrations and fecal fat excretion were measured. PS patients were followed for 5 years.ResultsAt the beginning of the study, 35 (19.0%) CF patients were PS, and 32 (17.4%) had normal E1 concentrations. Longitudinal measurements of E1 concentrations in PS patients with CF demonstrated stable enzyme output in 27 and gradual decrease in 8. The decrease was rapid in five infant patients and gradual in three older patients. The decrease of E1 concentrations preceded the appearance of steatorrhea in all eight subjects.ConclusionsThe decline of EPF in patients with CF appears more frequently during the first months and years of life. However, late PS to pancreatic-insufficient (PI) conversion is also possible. The appearance of maldigestion is preceded by the decrease of fecal E1 concentration. Thus, the fecal E1 test is a helpful screening tool for the longitudinal assessment of declining EPF in PS patients with CF to demonstrate pancreatic deterioration. In suspected patients, fecal fat excretion should be assessed.
ISSN:0277-2116
出版商:OVID
年代:2003
数据来源: OVID
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