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11. |
Activated Eosinophils in Esophagitis in Children: A Transmission Electron Microscopic Study |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 194-198
Justinich*‡ Christopher,
Ricci† Andrew,
Kalafus*‡ Dolores,
Treem*‡ William,
Hyams*‡ Jeffrey,
Kreutzer§ Donald,
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摘要:
BackgroundEsophagitis in infants and children is often characterized by eosinophilic inflammation. The underlying pathophysiologic mechanisms leading to this type of inflammation, and the role of eosinophils in the clinical expression of esophagitis, are unknown. The purpose of this study was to demonstrate the ultrastructural activation state of eosinophils in esophagitis in infants and children.MethodsStandard transmission electron microscopy was used to examine endoscopic esophageal biopsy material from patients with and without esophagitis, as defined by standard histologic criteria.ResultsTwelve esophagitis and three control cases were studied. In patients with esophagitis, electron microscopy revealed numerous eosinophils throughout the mucosa and invariably demonstrated signs of activation, including inversion of coreto-matrix densities and lucency of granule core protein. Eosinophils in an activated state were seen in active diapedesis through vascular endothelium into the mucosa. Eosinophils were sometimes seen in proximity to lymphocytes. Biopsies of control patients did not demonstrate eosinophils.ConclusionsEosinophils present in esophagitis are activated by electron microscopic criteria, and can been seen in an activated state entering into the mucosa. This suggests that eosinophils play an active role in the pathophysiology of this disorder, and that proinflammatory factors are present that selectively recruit and activate eosinophils in esophagitis in children.
ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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12. |
Use of Cisapride in Treatment of Constipation in Children |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 199-203
Odeka E.,
Sagher F.,
Miller V.,
Doig* C.,
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摘要:
BackgroundChronic constipation is a common problem in children. We observed the effects of cisapride in the management of idiopathic constipation in children.MethodsThirty-seven children with a history of constipation (i.e.. pain and difficulty or delay in defecation for >3 months) were recruited and randomly assigned to 8 weeks of treatment with either cisapride, 0.2 mg/kg three times daily, or matching placebo after a 2-week run-in period in a double-blind, parallel-group study design. In phase 1 (2 weeks), patients had plain abdominal radiographs to assess degree of faecal load, and those with impaction were given laxatives. After satisfactory clearance of faeces, total gastrointestinal transit time and orocaecal transit time were measured. In phase 2, after 8 weeks of treatment with either cisapride or placebo (0.2 mg/kg t.d.s.), the transit studies were repeated.ResultsCompared with placebo, cisapride did not improve either stool frequency or transit time in this study population.ConclusionThis study did not demonstrate a clinical role for the use of cisapride in the treatment of idiopathic constipation in children.
ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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13. |
Surgical Therapy and Follow-up of Pancreatitis in Children |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 204-209
Petersen C.,
Goetz A.,
Bürger D.,
Mildenberger H.,
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摘要:
BackgroundAcute and chronic pancreatitis in children differ from that in adults both from the etiology and the therapeutic approach. Within the frame of a blunt abdominal trauma-the most frequent cause in children-acute pancreatitis is often detected by emergency laparotomy and external drainage is recommended. Chronic relapsing pancreatitis, and particularly its hereditary form, is very rare in children and requires a different therapeutic concept. The results of surgical therapy for both forms of pancreatitis in childhood were evaluated in the present study.MethodsSixteen patients with acute and chronic relapsing pancreatitis were operated on in our facility between 1976 and 1988. Their history and postoperative course were analyzed in a retrospective study, including a final examination at the end of the follow-up period.ResultsEight children with acute pancreatitis were operated on at an average age of 6 years and were followed up for an average of 7.5 years, with good results. The remaining children, aged between 3 and 14 years (average age of 9 years), were operated on for chronic relapsing pancreatitis. Our experience with early operative treatment, on average 2.7 years after onset of symptoms, is presented. Only three patients experienced a mild relapse during the follow-up period of 2-13 years (average of 5.4 years).ConclusionsFor acute pancreatitis in childhood, operative treatment by inner drainage is necessary and effective only in case of complications, should conservative treatment fail. In children with chronic relapsing pancreatitis, the good exocrine and the normal endocrine function of the pancreas in these patients justified the early operation. Timely treatment is recommended in cases with typical changes of the pancreatic duct so as to shorten the relapsing clinical problems of the children and to maintain the function of the pancreas.
ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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14. |
Gastrointestinal Cytomegalovirus Infection Complicating Crohn's Disease in an Adolescent Without AIDS |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 210-213
Drouin E.,
Seidman E.,
Russo* P.,
Deslandres C.,
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ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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15. |
Phytobezoar-Induced Ileal and Colonic Obstruction in Childhood |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 214-216
Efrati Yigal,
Freud Enrique,
Serour Francis,
Klin Baruch,
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ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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16. |
Noenatal Protein-Losing Enteropathy Caused by Intestinal Lymphatic Hypoplasia in Siblings |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 217-221
Hardikar Winita,
Smith Arnold,
Chow* C.,
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ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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17. |
Ovarian Neoplasm and Endometrioid Carcinoma in a Patient with Turcot Syndrome |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 224-227
Shalon* Linda,
Markowitz* James,
Bialer* Martin,
Kahn† Ellen,
Weinblatt* Mark,
Giardiello‡ Francis,
Luce§ Michael,
Daum* Fredric,
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ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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18. |
Oral Insulin is Biologically Active on Rat Immature Enterocytes |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 230-232
Buts Jean-Paul,
De Keyser Nadine,
Sokal Etienne,
Marandi Soheila,
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ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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19. |
Disseminated Nocardiosis Complicating Medical Therapy in Crohn's Disease |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 233-235
Vohra Pankaj,
Burroughs* Margaret,
Hodes* David,
Norton† Karen,
Kaufman‡ David,
LeLeiko Neal,
Benkov Keith,
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ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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20. |
Recommended Dietary Allowances (RDAs), Recommended Dietary Intakes (RDIs), Recommended Nutrient Intakes (RNIs), and Population Reference Intakes (PRIs) are not “Recommended Intakes” |
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Journal of Pediatric Gastroenterology and Nutrition,
Volume 25,
Issue 2,
1997,
Page 236-241
Aggett P.,
Bresson J.,
Haschke* F.,
Hernell O.,
Koletzko B.,
Lafeber H.,
Michaelsen K.,
Micheli J.,
Ormisson A.,
Rey† J.,
de Sousa J.,
Weaver L.,
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ISSN:0277-2116
出版商:OVID
年代:1997
数据来源: OVID
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