ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05902.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

Analysis of “reactor” and control groups of blood bank donors reveals from a statistical standpoint younger donors, particularly female, with a previous history of fainting are more prone to reaction. The “reactor” group had a tendency toward a higher pulse rate and pulse pressure and a lower diastolic pressure before bleeding. Race, blood type and body temperature did not influence the incidence of reactions. It was three times more likely for a one‐time “reactor” to have a subsequent reaction than for a control donor. This distinct tendency toward multiple “reactors” makes it very probable that there exists a “reactor‐prone” type. The fundamental cause of the reaction as well as the defect in the “reaction‐prone” donor are unknown. Closer study of “multiple reactors” would seem to be a profitable appro

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05903.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05904.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

A study was made of the cardiovascular and hematologic responses of 28 male and 13 female normal blood donors to withdrawal of about 500 ml. of blood. During the bleeding there was a predominant tendency toward a fall in systolic and a rise in diastolic blood pressure, a mild rise in net peripheral resistance, a slight fall in cardiac output and respiratory rate with little change in heart rate. The prothrombin time and partial thromboplastin time were unchanged but there was a significant fall in plasma clotting time. Immediately upon cessation of bleeding the hemoglobin and hematocrit values indicated a “dilution quotient” of 2 to 2.5 per cent but plasma fibrinogen, plasma prothrombin and leukocyte counts suggested a prompt and rapid over‐dilution of the plasma. In three donor reactions occurring in the course of the study, the primary changes were a sharp fall in blood pressure, peripheral resistance and pulse rate. It is suggested that the mechanism of post‐phlebotomy fainting may involve undue sensitivity of the intracranial circulation to neurohumoral agents, inadequacy in the functional “central blood volume” or deficient peripheral vascul

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05905.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

The serum of a Memphis Negress was found to be incompatible with all donors tested. She had had 11 pregnancies and had received 16 pints of blood between 1955 and 1957. She was found to be strongly Js(a+) and her four living children were all Js(a+). Her serum was tested against the red cells of two sisters believed to be homozygous for Jsabecause all their ten children are Js(a+). They were found to be compatible. Thirteen of 1,269 Memphis and Milwaukee Negroes were found to be ccmpatible. Twelve of these were tested with anti‐Jsaand all were positive. The probability of selecting 12 consecutive Js(a+) Negroes by chance is only four in a billion. The proportion of 0.0102 non‐reactors among the 1,269 Negroes tested agrees well with Giblett's estimate of 0.0106. The antibody has therefore been designated as anti‐Jsb. No Js(b–) individuals have been found among 1,005 Caucasians

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05906.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

A Canadian family of British descent has been found among whose m?mbers 17 heterozygous examples of the rare Rh chromosomeD– were detected in addition to the homozygousD–/D– propositus. The parents of the propositus were first co

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05907.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

A third example of anti‐hrS, first described by Shapiro in 1960, was detected in the serum of a Bantu woman whose newborn infant suffered from mild hemolytic disease of the newbor

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05908.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05909.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

摘要:

A pregnant woman for whom it was not possible to find compatible blood needed for transfusion, was found to have the rare blood type pp (Tja‐negative) with anti‐P + P1antibodies in her serum. The patient was one of ten living sibs among whom four brothers and one sister had the same rare type as the proposita. Results of genetic and immunohematologic studies on this sibship and their parents were presented. The obstetric history of the proposita included three miscarriages. The fourth pregnancy, terminated by cesarean section, resulted in a premature infant, whose death was attributed to hyaline membrane disease. The fifth pregnancy ended with a full‐term normal infant who remained free of disease. Positive direct antiglobulin tests were obtained with cord blood specimens of both infants, indicative of transplacental transfer of the maternal anti‐P + P1antibodies. However, manifest hemolytic disease of the newborn did not develop in either infant. The observations made in this study were compared with data recorded in the literature on this subject and discussed in relation to clinical and laboratory problems arising from the presence of the rare blood

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05910.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY

ISSN:0041-1132    

DOI:10.1111/j.1537-2995.1963.tb05912.x

出版商:Blackwell Publishing Ltd    

年代:1963

数据来源: WILEY