摘要:

Abstract:The chronotropic and inotropic effects as well as the tissue levels of digoxin and methyldigoxin were studied in isolated guinea pig atria. Higher concentrations of methyldigoxin than of digoxin were required to cause arrhythmias. The inotropic potencies of the two glycosides did not differ from each another in equimolar concentrations in the organ bath. The increase in contractility correlated with the level of the glycoside in the organ bath and in the tissue. Digoxin was more effectively taken up by the heart tissue than methyldigoxin. Thus, when the tissue levels of the glycosides were the same, the contractility was greater after methyldigoxin than after digoxin.

ISSN:0001-6683    

DOI:10.1111/j.1600-0773.1977.tb03556.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract:Suckling rats were exposed for 15 and 30 days to manganese through the milk of nursing dams receiving 15 mg MnCl24H20/kg/day orally and after which the neurological manifestations of metal poisoning were studied. No significant differences in the growth rate, developmental landmarks and walking movements were observed between the control and manganese‐exposed pups. The metal concentration was significantly increased in the brain of manganese‐fed pups at 15 days and exhibited a further three‐fold increase over the control, at 30 days. The accumulation of the metal in the brain of manganese‐exposed nursing dams was comparatively much less. A significant decrease in succinic dehydrogenase, adenosine triphosphatase, adenosine deaminase, acetylcholine esterase and an increase in monoamine oxidase activity was observed in the brain of experimental pups and dams. The results suggest that the developing brain may also be susceptible to ma

ISSN:0001-6683    

DOI:10.1111/j.1600-0773.1977.tb03557.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract:Methylergometrine concentrations in human and rabbit plasma were determined by a new radioimmunoassay after a single intravenous injection (0.2 mg in man and 0.05, 0.1 and 0.2 mg/kg in rabbits). Both in man and in the rabbit methylergometrine disappeared quickly from the plasma with a mean T1/2βof 1.8 and 1.2–1.7 min. respectively. Similarly, the T1/2/α‐values were 32.1 and 27.3–93.2 min. The mean maximal response in the rabbit uterusin situafter 0.05, 0.1 and 0.2 mg/kg intravenously dose was found at 40 sec, 26 sec, and 26 sec. after the drug administration, respectively, and the dose response curve was quite steep. A significant correlation was found between the dose and r

ISSN:0001-6683    

DOI:10.1111/j.1600-0773.1977.tb03558.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract:The distribution of copper and zinc among soluble hepatic proteins in lambs from 1 normal and 1 copper dosed ewe was studied by gel filtration. It was found that the distribution pattern is similar in newborn lambs and their dams. The amount of copper in the liver indicated that a placental transfer and accumulation of copper is possible in lambs.

ISSN:0001-6683    

DOI:10.1111/j.1600-0773.1977.tb03559.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract:Hexachlorobenzene (HCB)‐pretreatment of rats leads to an increase in liver microsomal 2,4‐diaminoanisole activation to a mutagen after a dose of 10 mg/kg intraperitoneally and to an increase in ethylmorphine N‐demethylase after a dose of 50 mg/kg intraperitoneally. 2,4‐Diaminoanisole mutagenicity was increased 24 hrs after HCB‐pretreatment, whereas ethylmorphine N‐demethylase first increased after 48 hrs. There is a sex difference in the inducing effects of HCB on ethylmorphine N‐demethylase, but not on 2,4‐diaminoanisole mutagenicity. HCB‐pretreatment also leads to increases in 2,4‐diaminoansiole mutagenicity in the kidneys, but not in the lungs

ISSN:0001-6683    

DOI:10.1111/j.1600-0773.1977.tb03560.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Abstract:The possible influence of food intake on the bioavailability of the anxiolytic drug oxazepam was assessed in eight healthy volunteers taking a single dose of the drug both on an empty stomach and together with a standardized breakfast meal. The serum concentrations of oxazepam were determined by gas chromatography on samples obtained before, and at numerous occasions up to 48 hours after drug administration. The results indicate that concomitant food intake has no essential influence on the bioavailability of oxazepam.

ISSN:0001-6683    

DOI:10.1111/j.1600-0773.1977.tb03561.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-6683    

DOI:10.1111/j.1600-0773.1977.tb03562.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY