ISSN:0268-8697    

DOI:10.3109/02688698808992661

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

ISSN:0268-8697    

DOI:10.3109/02688698808992662

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

Surgical operations for the treatment of intractable temporal lobe epilepsy have been used for well over 40 years and yet there is still controversy about both the clinical situation in which these operations are indicated and their theoretical basis. This brief essay is an attempt to explain and resolve some of these difficulties.

ISSN:0268-8697    

DOI:10.3109/02688698808992663

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

A prospective study in which the effect of the post-ictal systemic blood pressure levels on the outcome following surgically treated aneurysmal subarachnoid haemorrhage (SAH) in 325 patients is reported. No differentiation was made between pre-existing essential and prolonged reactive hypertension. A significant association was found between the trend for rising diastolic blood pressure levels and the tendency towards a poor outcome. There was a similar trend for rising systolic blood pressure levels which did not reach statistical significance. Patients with definite hypertension (blood pressure of 160/95 mmHg or greater) were 1.6 times as likely to have a poor outcome than were those with lower blood pressures.

ISSN:0268-8697    

DOI:10.3109/02688698808992664

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

Eight patients with subarachnoid and/or intraventricular haemorrhage underwent continuous extraventricular drainage and cerebrospinal fluid production was estimated by modified open drainage. The patients were in Hunt&Hess grades 2–5 on admission. Drainage was instituted within 24 h after the last bleeding episode in seven patients and the duration of drainage was 3–37 days. The median amount of CSF that was drained in 24 h was 210 ml. CSF production rate was 0.10–0.55 ml/min (median 0.28 ml/min) and there was a great variation within as well as between patients. Thus there was a trend towards a reduction in CSF production compared to reported normal values for CSF production. Three of six surviving patients required a shunt. The possible role of reduction in CSF production rate in the modification of intracranial hypertension and hydrocephalus after subarachnoid haemorrhage is discussed.

ISSN:0268-8697    

DOI:10.3109/02688698808992665

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

Early changes of the activity of enzymes such as creatine kinase in the cerebrospinal fluid (CSF) or serum are often investigated after head injuries to assess the extent of brain damage and establish a reliable prognosis. The purpose of the present study was to determine levels of creatine kinase isoenzyme CK-BB in the CSF of rats after experimental head injuries. External head injuries of different severity were inflicted on rats, immediately after which CSF was collected for isoenzyme activity determination. It was found that the levels of CK-BB were significantly elevated immediately after the head injury and that the greater the degree of external cranial injury inflicted, the higher the isoenzyme activity was. The results seem to provide evidence that CK-BB activity is an early indicator of brain damage and that its level may reflect the extent of cerebral damage involved.

ISSN:0268-8697    

DOI:10.3109/02688698808992666

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

A new method of microvascular decompression of the facial nerve using sling retraction is described. This method may elucidate the way in which this microsurgical exploration in the posterior fossa relieves hemifacial spasm.

ISSN:0268-8697    

DOI:10.3109/02688698808992667

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

The localisation of the radioiodinated Fab fragment of monoclonal antibody (Mab) 81C6, reactive with a glioma-associated extracellular matrix antigen, was studied in athymic mice bearing subcutaneous and intracranial xenografts of D-54 MG glioma cells.In vitro81C6 Fab showed a marked loss of immunoreactivity and affinity for antigen compared to intact Mab 81C6.In vivothe plasma half-life of 81C6 Fab was 7.0 hours compared to 2.1 days for 81C6. 81C6 Fab levels in tumours peaked at 2.6–3.8% injected dose/g in 2–6 h; Mab 81C6 reached 33.9% dose/g at 48 h. Localisation indices and tumountissue ratios were superior for Mab 81C6. Estimated radiation doses to tumour and normal tissues were lower for131I-81C6 Fab than131I-81C6. To realise the theoretical benefits of fragments as localising agents, Fab fragments of higher immunoreactivity and affinity, or bivalent F(ab')2fragments are required.

ISSN:0268-8697    

DOI:10.3109/02688698808992668

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

F(ab')2-fragments of the anti-melanoma monoclonal antibody Mel-14 were labelled with123I for external scanning and withl25I for tissue measurement of radioactivity and injected intravenously into patients scheduled for surgical resection of a glioma. The paired-label study was performed by injecting simultaneously131I-labelled control (F(ab')2-fragments. The patients were scanned by computerised tomoscintigraphy. After surgery, the activities of125I andl3I were counted in tumour and normal tissues. The results indicate that there was a low but definite uptake of the antibody in the tumour due to its specificity. The external detection was difficult because of accumulation of antibody fragments in the skull.

ISSN:0268-8697    

DOI:10.3109/02688698808992669

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor

摘要:

A monoclonal antibody (UJ181.4) was labelled with131I and given intrathecally to a patient who was critically ill with neoplastic meningitis due to a disseminated pineoblastoma. The target antigen had first been demonstrated on tumour cells by immunocytological testing of cerebrospinal fluid (CSF). As a preparation for therapy, a test dose of13II-UJ181.4 antibody was given simultaneously with a control antibody labelled with125I. Good evidence ofin vivoimmunolocalisation was obtained by external gamma counting and by analysis of the radiolabels on centrifuged CSF cells. Specificity ratios of between 10:1 and 20:1 were obtained by these methods. A single relatively small therapeutic dose of131-I (870 MBq) given by the intrathecal route, resulted in a marked clinical improvement and sustained remission for 22 months.

ISSN:0268-8697    

DOI:10.3109/02688698808992670

出版商:Taylor&Francis    

年代:1988

数据来源: Taylor