ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00941.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Book reviewed in this article:Veterinary Laboratory Medicine:Clinical Pathology, Third Edition. J. Robert Duncan Keith W. Prasse Edward A. Mahaffey. 1994. $42.95. 302 pp. Illus. Index. Published by Iowa State University Press, 2121 South State Avenue, Ames, IA 50014‐8300; (800) 862–6657; fax (515) 292–3348.Managing the Veterinary Cancer Patient:A Practice Manual. By Gregory K. Ogilvie and Antony S. Moore. 1995. $59.00. 542 pp. Illus. Index. Published by Veterinary Learning Systems Books, 425 Phillips Boulevard #100, Trenton, NJ 08618‐1496; (800) 426–9119.Cancer Chemotherapy in Small Animal Practice. Jane M. Dobson, Neil T. Gorman. 1993. Published, and represented in the U.S by Blackwell Scientific Publications, Inc. Marketed by Veterinary Practice Publishing Company, P.O. Box 4457, Santa Barbara, CA 93140‐4457; (80

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00942.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00943.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00944.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

This study was conducted to determine the relationship between factor VIII (FVIII) activity and von Willebrand factor antigen (vWf:Ag) concentration in canine von Willebrand Disease (vWD). In addition, the clinical utility of measuring FVIII activity in vWD was assessed. This was performed by the concurrent analysis of both FVIII activity and vWf:Ag concentration in three breeds of dogs, namely Dobermans (n = 183), Scottish Terriers (n = 169), and Labrador Retrievers (n = 146). In the three breeds tested, linear regression analysis illustrated a positive relationship between FVIII activity and vWf:Ag concentration. This was reaffirmed in the Doberman and Scottish Terrier breeds, in which dogs with vWf:Ag concentrations>50 CU/dL (“carriers”) had lower median FVIII activities than dogs with vWf:Ag concentrations>70 CU/dL (“normals”). The determination of various FVIII “cut‐off” values was a poor test to separate Dobermans with and without clinical signs of hemorrhage attributable to vWD. In addition, the occurrence of hemorrhage in Dobermans with vWf:Ag concentrations>50 CU/dL was not influenced by the FVIII activity. Various tests were performed to determine if the measurement of FVIII activity aided in the identification of “carriers” of the vWD gene in the Doberman and Scottish Terrier breeds. These included the use of optimal FVIII “cut‐off” values for each breed and a FVIII “cut‐off” value of 55 CU/dL; FVIII/vWf:Ag ratios and FVIII/vWf:Ag ratio “cut‐off” values; and linear regression analysis of vWf:Ag concentration against FVIII activity. Of all these tests, only the determination of FVIII/vWf:Ag ratios appeared to have promise for “carrier” detection. The data in the present study indicated that routine FVIII assessment in vWD is not warranted; however, measurement of FVIII activity may be of use in

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00945.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

To better understand the relationship of portal lymphocytic infiltrates to feline inflammatory liver disease, liver sections were semiquantitatively evaluated from healthy cat and liver sections randomly selected at necropsy from clinical cases. Healthy specific pathogen‐free kittens and healthy young adult cats had up to 10 lymphocytes and plasma cells per portal area. Neutrophils were infrequently seen in portal areas. Approximately one‐third of sections obtained from clinical cases younger than 10 years had increased numbers of lymphocytes and plasma cells in portal areas. Seventy percent of these had a concurrent increase in neutrophils. Eighty‐two percent of liver sections obtained from clinical cases older than 10 years had increased numbers of portal lymphocytes and plasma cells. Almost all of these sections had concurrent fibrosis and bile duct proliferation. These data indicate that a progressive lymphocytic portal hepatitis is a common finding in cats older than 10

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00946.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00947.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1995.tb00948.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY