摘要:

SummaryPhagocytes undergo a sharp burst of oxygen consumption when engulfing bacteria. This oxygen is enzymatically reduced to toxic metabolites which are essential to the bactericidal action of the cell. Oxygen metabolites formed in this burst as well as other intermediates formed in biological reduction reactions do not selectively reserve their toxicity for microorganisms. Cells help to guard their organelles against the toxic effects of oxygen by producing intracellular enzymes such as superoxide dismutase. Though superoxide dismutase is found in relatively high concentrations inside cells, there are only small amounts in extracellular fluids. This may account for some of the local tissue damage surrounding aggregates of neutrophils in inflammatory reactions. A pharmacological preparation of superoxide dismutase has shown efficacy in preventing some of the pathological changes seen in degenerative arthritis.

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1983.tb00615.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryMultiple myeloma with “flaming” plasma cell infiltration of the bone marrow was found in an 8‐year‐old Shetland sheepdog. Immuno‐electrophoresis results indicated that the myeloma protein was IgA. Flaming plasma cells frequently have been associated with human Ig

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1983.tb00616.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1983.tb00617.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryA second‐antibody autoradiographic technique was found to be suitable for visualization of precipitin arcs produced by the elec‐troimmunoassay or crossed immunoelectro‐phoresis of factor Vlll‐related antigen in canine plasma. With the new autoradiographic procedure the electroimmunoassay was approximately ten times more sensitive than with the commonly used protein stain, Co‐omassie Blue R 250. Unlike earlier autoradiographic techniques, second‐antibody au‐toradiography requires only commercially avail

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1983.tb00618.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1983.tb00620.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

SummaryA nucleolar pattern of fluorescence was detected in an Antinuclear Antibody (ANA) test on serum of an 8‐year‐old Collie with Systemic Lupus Erythematosus (SLE). Skin disease characterized by a lymphoplasmacytic infiltrate and epidermal necrosis and a positive Coombs' test supported the diagnosis. The dog responded to immunosuppres‐sive drugs and continues to do well on maintenance th

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1983.tb00621.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0275-6382    

DOI:10.1111/j.1939-165X.1983.tb00622.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY