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11. |
Recognition of poliovirus/HIV chimaeras by antisera from individuals with HIV infection |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 425-430
Cherelyn Vella,
Philip Minor,
Ian Weller,
Owen Jenkins,
David Evans,
Jeffrey Almond,
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摘要:
The neutralization of five poliovirus/HIV chimaeras by serum from HIV-infected individuals was examined to evaluate the presentation of HIV envelope sequences, to assess the immune response of individuals to specific epitopes, and to relate it to the stage of disease. The sera were unable to differentiate between four of the chimaeras and the Sabin vaccine strain. With a fifth construct containing an immunodominant gp41 sequence, significant differential recognition was observed in approximately 67% of individuals with asymptomatic HIV infection [groups II and III of the Centers for Disease Control (CDC) classification of HIV infection] and 37% of patients with symptomatic disease (CDC group IV). Furthermore, among patients with CDC stage IV disease antibody levels against this construct and the titre achieved decreased with progression to further disease from approximately 40% in AIDS-related complex (ARC) patients (CDC group IVA and IVC-2) to 14% in those with AIDS (other group IV diseases). Loss of antibody to this construct did not result from a reduction in the anti-polio or anti-envelope response, but from a decline in antibody levels to the HIV sequence inserted in antigenic site 1.
ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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12. |
High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 431-436
Frank Stieneker,
Jörg Kreuter,
Johannes Löwer,
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摘要:
The aim of the present study was to determine the effect of polymethylmethacrylate (PMMA) nanoparticles as adjuvants for an HIV-2 whole-virus vaccine in mice. The data clearly revealed that PMMA nanoparticles induced 10–100-fold higher antibody titres than aluminium hydroxide or an aqueous vaccine control preparation as measured by enzyme-linked immunosorbent assay. Moreover, the high antibody titres obtained with PMMA as adjuvant appeared to be stable for between 10 and 20 weeks after immunization. In contrast, the titres of the control preparations, fluid or aluminium hydroxide formulations, decreased after 10 weeks.
ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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13. |
Risk of transfusion‐associated HIV transmission in Kinshasa, Zaire |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 437-440
Ilunga N'tita,
Kisi Mulanga,
Christian Dulat,
Daniel Lusamba,
Thomas Rehle,
Rolf Korte,
Helmut Jäger,
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摘要:
Between 5 March and 12 April 1990, we assessed transfusion practices and the risk of transfusion-associated HIV transmission in all the hospitals and medical centres in Kinshasa, Zaire. Of the 733 hospitals and medical centres surveyed, 62 (8.5%) transfuse blood. Of 3741 units of blood transfused in February 1990, 1045 (27.9%) were not screened for HIV infection. Eighteen out of 62 centres (29%) received HIV test kits on a regular basis. Twenty of the centres (32.3%) recorded HIV test results. Major blood group cross-matching was done by 9.7% (six out of 62) of the centres. Bacteriological results indicated contamination in 17% (four out of 23) of stocked blood units, 6.4% (four out of 62) of solutions for disinfections, and 22% (13 out of 59) of sterilized instruments (possessed by 59 centres only). Transfusion practices in Kinshasa are associated with considerable health risks. The establishment and appropriate supervision of HIV screening facilities should be integrated into primary health-care programmes in order to increase safe transfusions in Kinshasa.
ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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14. |
Antibody to histo‐blood group A antigen neutralizes HIV produced by lymphocytes from blood group A donors but not from blood group B or O donors |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 441-444
Maiken Arendrup,
John-Erik Hansen,
Henrik Clausen,
Claus Nielsen,
Lars Mathiesen,
Jens Nielsen,
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摘要:
Three virus isolates HTLV-IIIB/lyA, HTLV-IIIB/lyB and HTLV- IIIB/lyO, obtained by passaging and propagating the HTLV- IIIB/H9 isolate in three separate cultures of mixed peripheral blood mononuclear cells (PBMC) from donors of blood type A, B or O, respectively, were tested for susceptibility for virus neutralization by the monoclonal antibody (MAb) AH16 directed against the blood group A epitope. MAb AH16 was previously shown to inhibit cell-free virus infection using HTLV-IIIBpropagated in H9 cells. AH16 showed a concentration-dependent inhibition of the HTLV- IIIB/lyA isolate but did not inhibit the HTLV- IIIB/lyB or the HTLV- IIIB/lyO isolate. Specificity of the MAb-mediated inhibition was shown using A-antigen (tetrasaccharide). Thus, HIV infection of PBMC from donors with blood type A appears to induce expression of host-cell-encoded carbohydrate blood group A epitope on HIV which can be a target for MAb-mediated virus neutralization.
ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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15. |
Simian immunodeficiency virus (SIVsm) isolation from blood and brain of experimentally infected macaques |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 445-450
Disa Böttiger,
Barbara Keys,
Per Putkonen,
Lilian Walther,
Eva Fenyö,
Erling Norrby,
Bo Öberg,
Francesca Chiodi,
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摘要:
The possibility of using simian immunodeficiency virus (SIV)-infected macaques to study pathogenic events linked to HIV infection of the brain prompted us to investigate some of the virological features in SIV-infected macaques. Nine cynomolgus macaques were inoculated with SIVsmand killed at different times. We successfully isolated virus from the blood of all the animals and from the brains of eight. These results point to the early and regular spread of this lentivirus to the brain. Neutralizing activity was studied in the serum and cerebrospinal fluid specimens obtained from these macaques against a selected group of isolates. Cerebrospinal fluid did not show any neutralizing activity. Our findings integrate the observations from HIV-1 infection in man and indicate that SIV infection of macaques is a useful model for studying pathogenic events of brain infection.
ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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16. |
Bullous pemphigoid autoantibodies, HIV‐1 infection and pruritic papular eruption |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 451-454
Sabine Loës,
Liliane Didierjean,
Letizia Rieckhoff-Cantoni,
Karine Imhof,
Luc Perrin,
Jean-Hilaire Saurat,
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摘要:
Bullous pemphigoid (BP)-type autoantibodies were found by Western blot (WB) analysis of epidermal extracts in the serum of 38% of HIV-seropositive patients compared with 21 % of HIV-seronegative patients with chronic pruritus and 76% of patients with BP. They were further identified as BP autoantibodies (BPab) by immunoprecipitation and immunoelectron microscopy. Their incidence increased from 21% in HIV infection stage II to 37% and 43% in stages III and IV, respectively. Of the patients suffering from HIV-related chronic pruritic papulovesicular eruption, 75% showed circulating BPab as compared with 29% in those without skin problems (P= 0.0066) and, among them, 30% met the diagnostic criteria for BP when histology, WB, immunofluorescence and immunoelectron microscopy techniques were used. In conclusion, this study identifies an autoimmune skin reaction that may account for, or be related to, the distressing pruritic eruptions occurring in HIV-infected patients.
ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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17. |
Immunological incompetence in AIDS |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 455-456
John Moore,
Dominique Blanc,
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ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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18. |
Cultured trophoblastic choriocarcinoma cells differentially express HIV‐1 and cloned provirus |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 457-457
V. Zachar,
B. Spire,
N. Norskov-Luritsen,
J-C Chermann,
P. Ebbesen,
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PDF (176KB)
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ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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19. |
Premenopausal cytomegalovirus oophoritis in a patient with AIDS |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 458-458
U. Familiari,
L.M Larocca,
E. Tamburrini,
A. Antinori,
L. Ortona,
A. Capelll,
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ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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20. |
Kikuchi's lymphadenitis and HIV infection |
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AIDS,
Volume 5,
Issue 4,
1991,
Page 459-460
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PDF (339KB)
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ISSN:0269-9370
出版商:OVID
年代:1991
数据来源: OVID
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