摘要:

One hundred and four serum samples submitted to our laboratory for total phenytoin levels were also assayed for free phenytoin levels using the Abbott TDx and AxSYM immunochemistry analyzers (Abbott Laboratories; Abbott Park, IL, U.S.A.). Free phenytoin levels were assessed using ultrafiltrates obtained with the Centrifree Microfiltration system (Amicon, Inc.; Beverly, MA, U.S.A.). There was an acceptable correlation of free phenytoin levels between the two instruments (r= 0.994; mean value of free fraction was TDx = 1.7 µg/mL and AxSYM = 1.6 µg/mL). The mean free phenytoin values correlated well with previously reported values in the literature. Acceptable recovery (88.8%-101.5%) and precision (CV = 2.3%-11.0%) were also obtained. The results of this study indicated that free phenytoin levels can be obtained with acceptable accuracy and precision using the total phenytoin reagents.

ISSN:0163-4356    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Skin eruptions have been reported with the use of all antiepileptic drugs and there is a significant risk of cross-reactivity between these agents in causing serious eruptions such as Stevens-Johnson's Syndrome. Gabepentin is usually considered a safe agent for patients with a previous history of drug allergies and there have been no cases of skin eruption reported to the gabapentin post marketing surveillance. We report a patient who had severe Stevens-Johnson's Syndrome induced by phenytoin and later by carbamazepine. Subsequent use of gabapentin also resulted in a skin eruption which was limited to the lower extremities but without systemic or mucosal involvement. This case suggests that patients with a strong history of drug-induced idiosyncratic reactions may experience such reactions to gabapentin as well.

ISSN:0163-4356    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:0163-4356    

出版商:OVID    

年代:1999

数据来源: OVID