摘要:

AbstractThe pharmacological management of behavioural symptoms in Alzheimer's disease is limited by the dearth of effective agents in this area. The purpose of this study was to determine whether trazodone or buspirone are helpful in the treatment of behavioural disturbance in AD. Ten patients meeting NINCDS criteria for AD with behavioural complications were administered trazodone (up to 50 mg tid), buspirone (10 mg tid), and placeboin a 12‐week double‐blind, crossover design. Outcome measures were the Brief Psychiatric Rating Scale (BPRS), the Dementia Mood Assessment Scale (DMAS), and the Buschke Selective Reminding Task. The data were analysed by ANOVA. Compared to placebo, trazodone produced a small but significant reduction in BPRS and DMAS scores (p<0.05), indicating improvement in behaviour but no change in cognitive measures. In contrast, buspirone has no significant effect on either behavioural or cognitive measures compared to placebo. The results of this pilot study suggest a beneficial role for trazodone, but not buspirone, in the treatment of behavioural disturbance in AD. Further studies using a wider range of doses of trazodone in more behaviourally disturbed AD patients should now be initiated in an attempt to replicate and expand on this preliminary find

ISSN:0885-6230    

DOI:10.1002/gps.930090112

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractNinety‐four patients on geriatric wards were examined as part of a study of prevalence of psychiatric disorders in elderly inpatients. A good correlation was found between depression measured on the HAD and on the Montgomery–Asberg scale. Lower, but still highly significant correlations were found between anxiety measured on the HAD and on the brief anxiety scale (BRAS), between anxiety on the self‐rating anxiety scale (SRAS) and the BRAS, and between anxiety on the HAD and the

ISSN:0885-6230    

DOI:10.1002/gps.930090113

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

摘要:

AbstractThe purpose of the study was to ascertain if comparable results could be obtained with a crisis intervention service operating during normal working hours as with a round‐the‐clock service. A follow‐up study, over a period of 3 years, was conducted on a cohort of 70 patients aged 65 years and over who were referred urgently to a Crisis Intervention Team over a 6‐month period. This team operated on a 9–5 basis. Outcome under several headings was compared with outcome in a previously reported 2‐year follow‐up study of a crisis intervention service which operated on a 24 hr basis. This group had comparable age and sex distribution, and similar proportions living alone at referral. Diagnostic groupings were similar and in both groups similar percentages of those referred were admitted (31% of 9–5 group vs 29% other). Notable differences were a greater referral rate in the 24 hr group and significantly greater numbers living in residential accommodation in the 9–5 group. Over the follow‐up period 9% of the 9–5 group were admitted vs 5% other. There was a greater use of community services by the 24 hr group. Mortality was almost identical in both groups. The finding that on many outcome criteria results were as impressive in the service operating during normal working hours as in the round‐the‐clock service has important service implications. However, caution is needed in interpreting the results due to the difficulties of comparing two geographically separate services with varied demographic differences. Suggestions for further analysis of models of

ISSN:0885-6230    

DOI:10.1002/gps.930090114

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6230    

DOI:10.1002/gps.930090115

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6230    

DOI:10.1002/gps.930090118

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6230    

DOI:10.1002/gps.930090119

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6230    

DOI:10.1002/gps.930090120

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6230    

DOI:10.1002/gps.930090121

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY

ISSN:0885-6230    

DOI:10.1002/gps.930090101

出版商:John Wiley&Sons, Ltd.    

年代:1994

数据来源: WILEY