摘要:

SYNOPSISExperiences gained in this laboratory during long‐term, separate prophylactic trials utilizing three different calcium channel blockers among patients with common migraine, classic migraine, mixed and chronic cluster headaches are reviewed. Nifedipine provided symptomatic improvement among 65% of patients with common migraine and among 77% of patients with classic migraine. Forty‐one percent of patients with mixed headache reported some relief of head pain. Sixty percent of patients with chronic cluster reported improved control of their headaches. Verapamil produced improved control of symptoms in 81% of patients with common migraine, 72% of those with classic, 67% of those with mixed and 79% of those with cluster. Nimodipine was reported to be beneficial among 84% of patients with common migraine, among 73% of those with classic migraine and among 53% with chronic cluster. Only 33% of patients treated with nimodipine for mixed headache reported improvement. Side effects were more common with nifedipine (71%) than with verapamil (41%) and were least common with nimodipine (20%). Tolerance developed in 42% of those treated with nifedipine and in 49% of those treated with verapamil. Development of tolerance with nimodipine was rare (4%). Each of these three calcium channel blockers showed different and specific therapeutic efficacies which differed according to the clinical classification of the different types of vascular head pain undergoing treatm

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707364.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

摘要:

SYNOPSISWe studied the course of episodic cluster headache in 72 patients. Sixty‐two cases (86%) had a regular frequency of clusters per year. Most patients suffered from 1 bout a year. A prolonged remission (>1 year) did not change the frequency pattern of clusters per year. Fifty patients (69%) had a fixed pattern both of frequency and duration of bouts. Thirty‐seven patients (51%) had a regular frequency of bouts per year, a fixed duration of bouts and a fixed frequency of attacks a day.Our results show that the natural history of most cluster headache (CH) patients is characterized by a regular patt

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707370.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

摘要:

SYNOPSISThe prophylactic anti‐migraine effect of atenolol was compared to placebo in a multicentre study on 63 patients with classical and/or common migraine. The study design was double‐blind cross‐over and patients were given atenolol 100 mg o.d. or matching placebo during a study treatment period of 24 weeks. The effect of atenolol was significantly better than that of placebo: integrated headache values were reduced in 70% of the patients (p = 0.004) and the proportion of days with headache was reduced in 59% of the patients (p = 0.010). Few side effects were reported with both atenolol and placebo. This study shows atenolol to be safe and effective in the prophylactic treatment of mig

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707372.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707375.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

摘要:

SYNOPSISThere have been two previous case reports of complicated migraine headaches associated with the use of beta blockers. In this article we report a third case of complicated migraine in a patient with longstanding migraine headaches taking propranolol for hypertension. Visual field testing demonstrated a left homonymous hemianopsia and CT scan revealed a low density defect in the left posterior parietal‐occipital area without enhancement. A review of the literature on stroke in migraine and the mechanism of action of beta‐blockers are included. We question the appropriateness of the use of beta‐blocking agents for prophylaxis of migraines associated with or preceded by conspicuous sensory or motor def

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707381.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

摘要:

SYNOPSISA search for biological “trait” markers in migraine patients was undertaken. Migraine and control subjects were challenged with an oral dose of deuteratedr‐tyramine. Deuterium‐labelled conjugated and unconjugatedr‐tyramine andr‐hydroxyphenylacetic acid in 24 hour urine samples, as well as several endogenous biogenic amines and their acidic metabolites in blood and urine, were identified and quantitated by mass spectrometry with selected ion monitoring. In contrast to earlier reports, urinary conjugatedr‐tyramine was not significantly reduced in migraine. Platelet monoamine oxidase (withr‐tyramine as substrate) and phenolsulfotransferase (with phenol as substrate) activities were significantly reduced. Plasma unconjugated vanilmandelic acid and conjugated phenylacetic acid and urinary unconjugated 3‐methoxy‐4‐hydroxyphenylethylene glycol were significantly elevated in migraine. These parameters would not, however, be suitable as biological markers because the differences compared to controls did not attain a sufficiently high level of sta

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707384.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

摘要:

SYNOPSISOphthalmoplegia is a rare presentation of migraine. Ophthalmoplegic migraine is frequently encountered in children, but has rarely been observed in infancy. We report a case of an infant with paroxysmal episodes of vomiting followed by a few weeks long periods of oculomotor nerve palsy. The first episode occurred at 14 months of age and the second at two years. In both episodes full recovery of the ophthalmoplegia occurred without treatment. The differential diagnosis of painful ophthalmoplegia and the variety of therapeutic regimens are discussed.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707390.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

摘要:

SYNOPSISThe purpose of the present study was to compare the efficacy and safety of naproxen sodium (550 mg), acetaminophen (650 mg) and placebo in the treatment of muscle‐contraction, or tension headache.Six investigators participated in this randomized, double‐blind, 3‐way parallel study, in which 149 patients were entered. Each patient treated one episode of moderate‐to‐severe headache with the test medication. The intensity of the headache pain was recorded on 10 cm visual analogue scales (VASs) by patients for up to 12 hours after treatment with the study medication. In addition, the degree of pain relief (PR) was recorded in a similar manner. Mean pain intensities (Pls), percentage changes in mean pain intensities, pain intensity differences (PIDs) and the sum of these differences (SPIDs) were calculated.From the data collected in 124 patients eligible for efficacy analysis, naproxen sodium was shown to provide a significantly greater percentage change in mean PI compared to acetaminophen (p<0.01) or placebo (p<0.001). Mean PID and SPID scores also showed naproxen sodium to be significantly more effective in relieving pain compared to acetaminophen (p<0.02) or placebo (p<0.001). Mean pain relief scores and calculated total pain relief (TOTPAR) scores correlated well with the reduction in pain intensity. During the trial 13 patients reported side effects including nausea, dizziness and drowsiness. None of the side effects were considered clinically significant.The results from this study demonstrated naproxen sodium to be a well tolerated analgesic, which provided statistically significantly superior analgesia compared to acetaminophen or placebo in the treatment of muscle‐contraction or tensio

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707392.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

摘要:

SYNOPSISThe aim of this study was to evaluate the effect of Nimodipine on episodic cluster headache. 13 patents were studied in an open trial. The study design required that treatment be started 2 to 10 days after the beginning of cluster cycle. Nimodipine stopped clusters in 7 (53%) out of 13 patients within 10 days of treatment. We discuss the methodological aspects of drug assessment in episodic cluster headache.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707397.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1987.hed2707400.x

出版商:Blackwell Science Inc    

年代:1987

数据来源: WILEY