ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803119.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

摘要:

SYNOPSISMeasurements of noninvasive regional cerebral blood flow (rCBF) were made by the 133Xe inhalation method in 71 patients with different types of headache and 32 age matched normal controls. Flow gray (Fg) was calculated by two compartmental analysis from the x‐ray subtracted gamma curves, and extracerebral flow indices (EFI) were calculated as an estimate of the percentage contribution by extracerebral tissues.During the headache phase, mean Fg in a group (N = 13) with classic and common migraine was significantly higher compared to a comparable group (N = 12) measured in the headache‐free interval. Serial measurement made during progression in the severity of the migraine headaches showed accompanying increases in the mean Fg as the headache worsened. In 24 patients with severe migraine studied 2‐48 hours after the headache subsided, the mean Fg values remained significantly increased during this immediate post‐headache interval compared with patients who were headache‐free for six days or longer. Serial measurements made during and after the headache showed progressive reduction of mean Fg values to normal within six days after the headache subsided. Marked cerebral dysauto‐regulation was present during the migraine headache and showed progressive recovery as the headache subsided. Reduction of the head pain by administration of codeine decreased hemispheric Fg values but did not change the high flows in the basilar artery territory. Conversely, administration of ergotamine did not change hemispheric Fg values but reduced rCBF in brain stem‐cerebellar regions. Significant regional reductions of Fg correlating with the neurological deficit was measured during the prodrome of classic migraine and during the headache and post‐headache intervals of complicated migraine. During cluster headaches, mean Fg values were also significantly increased and the extracerebral flow indices showed marked increases with highest values recorded at the site of the headache. It was concluded that cerebral hyperperfusion during migraine headaches is mainly due to post‐ischemic reactive hyperemia but may be compounded by functional hyperemia due to the

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803122.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

摘要:

SYNOPSISSome systemic painful syndromes are often unclassifiable because of their unconvincing clinical features and often labelled as hysterical, psychogenic or atypical manifestations of fibrositis or rheumatism. Some of these are grouped in a new syndrome called systemic "non‐organic central pain (NOCP)". The most salient features of systemic NOCP are: a) diffused pain subsequent to and accompanying idiopathic headache, b) characteristics of pain similar to, if less pronounced, than organic central pain of the thalamic syndrome and c) decentralization supersensitivity to monamines. Systemic NOCP was diagnosed in 14 patients admitted to the hospital for serious disabling systemic pains. In 7 of these, an impressive increase of vein sensitivity to noradrenaline, dopamine, tyramine, and even more so to 5‐HT (up to 1000 times), was detected. Because this supersensitivity involves different monamines, it should be considered a decentralization process. This decentralization supersensitivity is related to the mechanism of pain and is hypothesized as a non‐organic, biochemical, usually genetic impairment of the antinociceptive system. Migraine, tensional and other idiopathic headaches are more commonly considered expressions of NOCP. The clinical importance of NOCP is emphasized by its high neuroticizing capacity as is commonly seen in other chronic, recurrent pain diso

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803133.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

摘要:

SYNOPSISInformation on the prevalence of headache and its characteristic features and the factor provoking it was collected using a questionnaire similar to that introduced by Waters. The questionnaire was posted to every inhabitant over 15 years of age in a defined urban and a defined rural area in northern Finland. The reliability of the questionnaire was tested by neurological examination of a random sample of 200 persons. The response rate was 74.0% in the urban and 79.5% in the rural area, a total of 3067 questionnaires being returned. The prevalence of headache in the year preceeding the survey was 73.1% in women and 57.6% in men. This difference was significant. At the same time the prevalence was slightly higher in the urban than in the rural area. The percentage with headache was highest between 15 and 64 years of age in both the urban and the rural men and women, and declined sharply after 65 years of age. Only in men aged 15‐24 years was it significantly more common in the urban area. Education, social class and mode of employment did not influence the prevalence of headache once pensioners were excluded. Headache was slightly more common in urban self‐employed people and in urban employees, but equally common in urban and rural students, housewives and pensioners. It was significantly more common in married men and women. The percentage of women with headaches related to the menstrual period was low. The most common provoking factor was stress, the sauna‐bath ranking second. No correlation was found between smoking habits and headache in this s

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803137.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

摘要:

SYNOPSISA review of the literature suggested that falling levels of estrogen may trigger headaches for many women. A double blind controlled cross‐over study was carried out on 49 women, all of whom had undergone a surgical menopause. During the study each woman was randomly allocated each of the following drugs daily for three months: ethinyl estradiol 50 μg; d norgestrel 250 μg; combination of ethinyl estradiol 50 μg and d norgestrel 250 μg; and placebo. Women who reported they were headache free sufferers in the past had higher neuroticism and lower extraversion scores than others. Women who suffered headaches during a hormone free time interval had significantly higher plasma testosterone levels. An increase in the frequency of headaches occurred in association with a fall in estrogen content of the medic

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803146.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

摘要:

SYNOPSISA prospective study of 46 patients with mixed connective tissue disease (MCTD) revealed that 16 (35%) had recurrent, vascular headaches. Detailed neurologic evaluation of 12 headache patients available for further study revealed the following: 3 had lateralized, throbbing headaches; 9 had bilateral headaches; 8 patients experienced prodromal symptoms (7 had visual auras); and 3 experienced nausea or vomiting. Only 1 patient described headache as interfering with daily activities, and no patients were prostrated. Only 1 patient had frequently required narcotic (codeine) therapy, and none were employing ergot. Headache symptoms have persisted in 8 patients; 5 of these 8 suffer at least 1 headache per week. It appears that frequent vascular headache of mild to moderate severity is a relatively common symptom in MCTD.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803154.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

摘要:

SYNOPSISIn order to assess whether an increased brain serotonin tone prevents migraine symptoms, eight migraine patients were treated with levotryptophan in the controlled trial. Plasma and lumbar CSF were collected approximately one hour after the last dose of amino acid on the second week during the headache‐free interval. Samples were also taken 4 hours after the onset of the headache attack. Visual evoked cortical potentials were recorded one hour after the ingestion of 500 mg of levotryptophan.In four of the eight migraine patients, headache indices were markedly lower during typptophan treatment than during placebo (levoleucine) treatment. Levotryptophan caused an elevation of plasma free and total tryptophan, and CSF‐tryptophan from their basal values obtained during placebo treatment. Therefore levotryptophan may be a worthwhile alternative for a selective and still incompletely characterized group of migraine patie

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803161.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803167.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803169.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1978.hed1803176.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1978

数据来源: WILEY