摘要:

SYNOPSISProdromes of classic migraine were retrospectively studied from the records of 325 patients as regards their type, number, duration, frequency and sidedness in relation to the headache phase. We conclude:1. Prodromes can affect any of the senses, but most commonly affect the visual field.2. When more than one prodrome was present, the most common combinations were: Visual + Sensory for two prodromes; visual + sensory + speech for three prodromes; and visual + sensory + speech + motor for four prodromes,3. Duration and Frequency of prodromes vary widely.4. A definite statement about sidedness of headache in relation to prodrome could not be made.We feel a prospective study of prodromes is necessary to examine prodrome phenomena in greater detail.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605216.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISElectroencephalographic and evoked potential studies were done during the ictal phase of migraine in a 22‐year‐old woman with basilar artery migraine. Prominent posterior slowing was seen in the EEG pattern during the symptomatic period. Clinical improvement coincided with the reversal of abnormality in the EEG tracing. The findings from the multimodality evoked potentials were within normal lim

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605220.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISThe effect of needle size on postural headache after diagnostic lumbar puncture was studied in 300 patients at the Outpatient Department of Neurology, University of Helsinki. In three groups of 100 patients a needle size of 0.9mm (20 gauge), 0.7mm (22 gauge) and 0.6mm (23 gauge) were used, respectively. The total number of days with incapacitating postural headache in the groups diminished significantly with the decreasing needle size from 282 through 181 to 76 days. An analysis of CT scans performed in 95 patients showed that the incidence of post‐lumbar puncture headache significantly decreased with brain atrophy seen on CT independently of the needle size. The results suggest that the thinnest needle (0.6mm) usable without special techniques should be chosen for diagnostic lumbar punctures at outpatient department

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605224.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISFlunarizine was found to be effective in the acute treatment of isosorbide dinitrate induced migraine attacks, when given in a dosage of 10 mg sublingually.The present study consists of two parts: in the first preliminary investigation, 7 out of 8 migraine patients who developed a typical migraine attack after isosorbide dinitrate were relieved of pain within about 10 minutes. On the basis of this result a second, randomized controlled open trial was performed, in which the acute efficacy of flunarizine was compared with ergotamine tartrate, 0.25 mg i.m., on 40 migraine patients. Flunarizine was found as effective as ergotamine (75% positive responses in the flunarizine group, 70% in the ergotamine group). The mean latency of the flunarizine effect was significantly lower than that of the ergotamine (r<0.001, Student's t test). Moreover sublingual flunarizine was found to be virtually devoid of side effects.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605227.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISThirty subjects were admitted to a double blind study comparing Migraleve with placebo for the relief of acute common migraine attacks. A flexible dose cross over design was used. Twenty four subjects completed the six month study. The results suggest that Migraleve may reduce the duration and possibly the severity of an acute common migraine attack. Although the study was not designed to test for prophylactic effects since the drug was taken only for acute attacks, the results suggest possible long term prophylactic effects. These findings merit further investigation. While depressed patients had a greater number of common migraine attacks of all kinds, depression did not influence the effect of the drug. No serious side effects were noted in the patients during treatment, and the trial drug had an acceptably low incidence of other side effects. Of the 15 patients who expressed a drug preference in comparing the two 3 month study periods blindly, 14 expressed a preference for the Migraleve over the placebo. Further systematic study of these findings is necessary.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605231.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISSeventy‐four migraine sufferers were entered into a randomized, single‐blind study to compare the prophylactic effects of naproxen sodium and pizotifen. 550 mg naproxen sodium twice daily or 0.5 mg pizotifen three times daily were given for up to three months. Response to treatment was determined by monthly clinical assessments and daily patient self‐assessment.Both groups showed a significant decline in both the severity of migraine (p=0.001) and in the frequency of attacks (p = 0.02). No significant differences were detected between groups.Tolerance to both treatments was good. The most common adverse experience reported by the naproxen sodium treated patients was nausea (6 patients), whereas pizotifen gave rise to weight gain in five patients.The study has shown that naproxen sodium is a useful prophylactic agent for mig

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605237.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISBilateral blood volume pulse (BVP) recordings from the frontotemporal artery were obtained from a migraineur and eight non‐migraineurs prior to and following the presentation of a novel laboratory stressor ‐ the consumption of ice water. The results revealed a markedly different pattern of BVP activity in the migraineur compared to the non‐migraineurs. The implications of these findings for assessing the disregulation of the vasomotor response system are noted. In addition, the novel stressor used in this study may be used for inducing migraine attacks in controlled laboratory enviro

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605240.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISIn migraine, are there different metabolic responses to glucose ingestion, and if so, do the patients have different detectable characteristics which may be of use to determine their treatment?Thirty two volunteer migraineurs, for whom fasting was a known precipitant, were challenged with a glucose meal after an overnight fast. Symptoms and glucose levels were recorded at intervals over three hours. Examination of the changes in symptoms, elicited two groups with opposite responses, which were also significantly different with respect to circulating glucose levels. Furthermore, sub‐groups defined by dietary precipitants as expressed by the migraineur, were also found to be significantly different in both of these parameters.A treatment plan, for this type of migraine attack, based on the the dietary factors which may provoke its evolution and the response to glucose, is discusse

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605243.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY

摘要:

SYNOPSISSubstances such as chocolate and glutamate are triggers of migraine. These and some other “migrainous substances” contain little or no tyramine. This suggests that other dietary factors are involved in the precipitation of migraine. These food substances play a role in the utilization of copper, which is known to be involved in the metabolism of vasoneuroactive amines such as serotonin, tyramine and the catecholamines.This paper suggests that it is the effects that these substances have on the copper pathway (i.e. its absorption and utilization) that is the primary consideration in the precipitation of migraine. Chocolate contains high levels of copper. Glutamate acts to bind and transport significant amounts of copper between blood and tissues. Citrate, found in “migrainous citrus fruits,” increases the intestinal absorption of copper; and both ascorbate and citrate may act to decrease oxidation of tyramine and serotonin, thereby raising the effective levels of these substances and perhaps triggering a migraine attack.A migraine episode would be made more likely upon the ingestion of these substances by susceptible individuals with abnormal copper metabolism such as lowered levels or altered ceruloplasmin, transferrin or albumin (known to bind copper), or a change in copper tr

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1986.hed2605248.x

出版商:Blackwell Science Inc    

年代:1986

数据来源: WILEY