摘要:

SYNOPSISThirty patients with persistent chronic daily headache, unresponsive to various combinations ofpharmacological and non‐pharmacological treatment were selected for an open label study using divalproex sodium. All patients had normal liver function tests. After a baseline observation period of 1month, patients were given divalproex sodium 1000 to 2000 mg per day, for a period of 3 months. Blood valproic acid levels were kept between 75 and 100 mcg/ml. Liver function studies and blood ammonia levels were obtained periodically. Based on weekly headache index, headache‐free days, dysfunctional days and patients' general well‐being rating and physicians' global assessment, two thirds of the patients improved significantly. The common side effects included weight gain, tremor, hair loss and nausea. Liver functions were unaffected by treatment.The possible mechanism of action of valproate in headache is discussed. Valproate appears to be aworthwhile addition to the prophylactic treatment of chronic recurrent hea

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102071.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

摘要:

SYNOPSISA 25 year old patient presented with recurrent prolonged episodes of life‐threatening coma varying from 3 to 10 days. The clinical recovery was slow. The history and technical examinations led to the diagnosis of basilar artery migraine (BAM).The etiology of the coma episodes is thought to be related to ischemic dysfunction of the rostral part of the brainstem due to severe spasm of the basilar artery demonstrated by arteriography.Exceptional are the recurrent prolonged coma episodes of sudden onset, the severe spasm of the basilar artery, and the suppression‐burst and FIRDA pattern on the EEG examinations during the coma episo

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102075.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

摘要:

SYNOPSISThe aim of the present study was to investigate the effects of biofeedback training in the treatment of menstrual and non‐menstrual migraine. Accordingly, 39 female patients suffering from both migraine associated, and migraine not associated, with menstrual periods were drawn from a pool of research volunteers enrolled in a biofeedback treatment program for migraine headaches. All patients were required to complete 5 weeks of daily self‐monitoring of headache and menstruation activity immediately before and after treatment, and again at 6‐month follow‐up. Within‐subjects comparisons of the effects of biofeedback on menstrual and nonmenstrual migraine, and between‐subjects comparisons of the effects of biofeedback on patients suffering predominantly from either menstrual or nonmenstrual migraine showed that biofeedback is just as effective in reducing menstrual migraine as it is in reducing nonmenstrual migraine. Questions as to whether or not these conclusions can apply to patients who experience migraine headaches only during, or shortly before or after, menstruation,

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102082.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

摘要:

SYNOPSISVarious possible pathophysiological mechanisms to explain the pain in cluster headache are reviewed. Several locations for the initiation of pain along the primary afferent pathways in cranial nerves are discussed, together with the local mechanisms that might be responsible. These include neurogenic inflammation of large cranial vessels, irritation of vascular pain fibres by compression of dilated vessels in bony canals, and irritative foci in or around cranial sensory ganglia. In particular, recent neuroanatomical and pharmacological findings on nociceptive innervation of the intracranial segment of the internal carotid artery are commented upon. The possibilities for referred pain to explain the location of pain is illustrated. Evidence for involvement of central pain modulatory systems in the pain production is discussed. Finally a synthesis is made of the probable peripheral and central pain mechanisms in the disease.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102091.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

摘要:

SYNOPSISMonosodium glutamate (MSG), an established headache trigger, has become far more prevalent in canned, packaged and prepared foods over the past decade. The presence of MSG in food may be difficult to detect since the terms “natural flavor,”“flavoring,” or “hydrolyzed vegetable protein (HVP),” all may appear on food labels to refer to MSG, according to current FDA food labeling code. HVP typically contains 10–30% MSG.Case studies are presented in which the elimination of all food sources of MSG resulted in decreased headache frequency. Information and food lists helpful in identifying dietary MSG and HVP are presented. When patients are put on an MSG‐free trial diet, mention needs to be given to identification of the wide variety of foods contain

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102107.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

摘要:

SYNOPSISOnly one study has examined MMPI cluster profiles in the headache population. The present study expanded on this previous investigation by using a large samplesize(N=485) and a greater number of diagnostic categories. The five MMPI clusters replicated previous findings in the chronic pain literature. These MMPI cluster groups were compared to 5 diagnostic categories (migraine, cluster, post‐trauma, tension, mixed). No relationship was found between cluster type and headache diagnosis. While the diagnostic groups were found to differ on measures of pain severity, sex and age, cluster groups did not. It is proposed that MMPI scale types reflect a patient's response to pain and are more likely to be the result of coping resources than headache‐related personality style. Future research with additional, non‐painpopulations and prospective studies is sugg

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102111.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

摘要:

SYNOPSISThe associations between personality traits, life events and frequent headaches were studied in a sample of 5766 adult subjects between 20 and 65 years of age from the general population. Subjects with at least weekly headaches had more life events and higher inadequacy, social inadequacy, rigidity and injuredness than subjects with less frequent headaches. These relationships were not observed in subjects of 50 years of age and older, with the exception of the association with inadequacy. From the traits measured, inadequacy had the highest odds ratios for frequent headaches and showed a modest interaction with the presence of a life event. These findings are in agreement with Sarason's interactional model.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102116.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102123a.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102127.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1991.hed3102128_a.x

出版商:Blackwell Science Inc    

年代:1991

数据来源: WILEY