摘要:

SYNOPSISPlatelet cytosolic ionized calcium ([Cai2+]) was measured in aequorin‐loaded gel‐filtered platelets in the basel state and following stimulation with thrombin, collagen and platelet‐activating factor (PAF). 25 healthy controls, 20 interval migraine subjects and 26 acute ischemic stroke patients were studied. Compared to controls, the basal [Cai2+] was increased in migraineurs (p = 0.05) and after stimulation with PAF (p<0.03); thrombin‐ and collagen‐induced changes were similar to control. Compared to controls, basal [Cai2+] was increased in stroke patients (p<0.002); the increase in [Cai2+] after stimulation with thrombin (p<0.05), collagen (p<0.02) and PAF (p<0.05) was also greater in stroke. Compared to migraineurs, [Cai2+] was further increased in stroke after stimulation with thrombin (p<0.002) and collagen (p<0.02); PAF‐induced changes were similar in stroke and migraine.The greater concentration of basal cytosolic ionized Ca2+in platelets of migraine sufferers was associated with a normal response to activation by thrombin and collagen suggesting the presence of platelet hyporesponsiveness to activation by these agents in migraine sufferers. Unlike ischemic stroke patients where there is a nonspecific increase in response to platelet stimulating agents, the platelets of migraine sufferers appear to be specifically sensitive to activation by PAF suggesting that altered sensitivity to this phospholipid may be a characteristic unique to migrain

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806396.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThe purpose of this study is to demonstrate a simple technique for gaining information about the headache patient as a person. Eighty four headache patients while admitted to the hospital as in‐patients, over the past 8 years, were asked simply “to write about themselves”. The autobiographies which they eagerly supplied were amazingly frank and helpful in revealing details of their lives and feelings of a sort considered relevant to the management of the patient with hea

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806403.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThe distinctive clinical features of these conditions are borne out pharmacologically where drugs used with beneficial effects in one condition may exacerbate the other. This led us to investigate whether separate interacting/antagonistic receptor‐mediated transduction systems may be affected in these conditions. Previous work in our laboratory indicated that the prostacyclin stimulation of adenylate cyclase in lymphocytes was significantly reduced in cluster headache but unaffected in migraine. Hence in this study, we investigated the polyphosphoinositide system which upon receptor activation gives rise to two second messengers, inositol trisphosphate and diacylglycerol. The chemotactic factor stimulation of inositol phosphate production in polymorphonuclear leucocytes (PMNs) was used as the assay system. The maximum response was obtained at approximately 0.1μM chemotactic factor (EC50=13nM for control subjects). Female migraineurs (9 non‐smokers) were compared with a matched group of controls and found to have a significantly reduced PMN response to chemotactic factor stimulation (42% of control at 0.1 μM) while male cluster headache patients (7 smokers) showed a response slightly greater than a matched group of controls (male smokers). Interestingly, cluster headache patients undergoing lithium treatment showed a significantly reduced response (39% of the control response at 0.1 μM chemotactic factor). This indicates that lithium may have its beneficial effect in cluster headache by suppressing an overactive polyphosphoinositide system while being of little benefit in migraine where a substantial depression is already evident. Appropriate targetting of drugs to these transduction systems may offer a useful basis for tre

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806409.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISHemiplegic migraine during pregnancy is a ram occurrence, and recovery is usually spontaneous and complete. The presence of motor and sensory deficits with migraine should prompt the obstetrician to investigate for more serious neurological conditions.The literature contains few case reports of hemiplegic migraine during pregnancy. This paper discusses two case histories.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806414.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISTo investigate autonomic nervous system involvement in cluster headache (CH) and migraine, we compared the cardiovascular reflex responses of common migraine and CH subjects to a group of controls. A battery of 5 well‐codified autonomic tests was applied: (1) deep breathing test (DB); (2) lying to standing test (LS); (3) Valsalva manoeuvre (VAL); (4) postural hypotension test (PH); (5) blood pressure response to sustained handgrip (SHG). Our data confirm an autonomic dysfunction in CH, mainly affecting the parasympathetic system. Evidence for an impairment of sympathetic cardiovascular reflex regulation was obtained in the common migraine grou

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806417.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISEight patients with common migraine (CM), 9 with classic migraine (CLM), 5 with cluster headache (CH), and 10 with muscle contraction headache (MCH) were evaluated, before and after treatment, using electronic thermography of face (T.T.) and visual evoked potentials (V.E.R).In the 10 MCH's the T.T. and V.E.P. findings were comparable to those obtained from ten control subjects.In the three remaining groups we obtained the following results: Before therapy eighteen out of the 22 vascular headache patients showed a positive “cold patch” in the external carotid territory, ipsilateral to the prevailing side of pain. After six months on therapy the “cold patch” had disappeared or was attenuated in all the patients, who concomitantly had clinical improvement.Ten out of the 22 patients (all CH's, 5 out of 9 CLM, no CM) presented in the baseline condition an asymmetry in V.E.P.s (hemifield stimulation). After six months the asymmetry persisted in only 4 patients.The evidence supports a valid temporal relationship between the clinical improvement and the modification in T.T. and V.E.P.s findings in CLM and CH. In CM there is a relationship between clinical course and T.T. but not

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806423.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISConsiderable disagreement is found in the literature regarding the correlations between the degree of the electromyographically recorded tension of the head and cervical muscles, and muscle contraction headache.31 patients were admitted to the study and divided into 3 groups according to the diagnostic criteria of Ad Hoc Committee: vascular headache, muscle tension and mixed headache, in addition to 5 control subjects. The EMG recording was carried out with superficial electrodes on neck muscles during rest conditions (base EMG), under stress conditions (stress EMG), and finally during isometric contraction against resistance (max EMG).The exclusion from the study of patients with clinical characteristics definable as “psychogenic” headaches made it possible to obtain a homogeneous sample of patients with the diagnosis of muscle tension headache.Higher values of muscle tension in the group of patients suffering from muscle tension headache as compared to other groups of patients and to control subjects were fo

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806426.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISMost of the psychological and medical literature on childhood headache focuses on migraine headache. Very little research exists on the assessment and treatment of muscle‐contraction (MCH) in children. The present paper reviews current ideas on what constitutes a MCH in children, pathophysiology, prevalence, and assessment and treatment approaches. The medical and psychological literature indicates childhood MCH is similar to adult MCH. MCH is believed to be caused by psychological or stress‐related factors; however, only a few studies have addressed this issue with children. Questions remain as to what psychological factors to assess, and the best approach with children. Difficulties exist in obtaining reliable accounts of stressful events as well as headache symptoms. Pain diaries or questionnaires completed during the head pain may prove useful. Several studies have evaluated the use of EMG biofeedback and/or relaxation training with children MCH sufferers. Results are encouraging but methodological shortcomings prohibit firm conclusions. It is concluded that further research with childhood MCH is warranted in order to obtain a more complete medical and psychological understanding. Furthermore, this information is useful in differential diagnosis and for effective intervention in a chronic pain condit

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806430.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806435.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2806437.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY