摘要:

SYNOPSISA random group of children (n = 129; age up to 14 years; mean 6.5 years of age) admitted with closed head injury (CHI) was followed over a number of years. It was investigated to what extent a relationship existed between headache complaints and the injury. In the first weeks after the accident significant correlations existed between headache and the female sex, and between headache and electroencephalographic (EEG)abnormalities. Subsequently, there was no clear relationship between headache and any of the injury variables, At the end of the follow‐up period, an average of 5.9 years after the accident, it appeared that in the then checked children (n = 129) there was no relationship between headache complaints and the CH

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803176.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISIn this multicenter, double‐blind, parallel study, patients with muscle contraction headache were randomized to treatment with either two naproxen sodium 275 mg capsules per headache or matching placebo. Of a total of 161 patients enrolled, 137 received trial medication and 134 (63 taking naproxen sodium and 71 taking placebo) were valid for efficacy analysis. During four headache episodes, patients recorded, on a visual analog scale, pain intensity just before the dose of trial medication (baseline) and at1, 2, and 4 hours after this dose. For each patient, two additional indices were derived from these data: Pain Intensity Difference (PID), the difference between intensity of pain at baseline and intensity of pain recorded at any time after treatment began; and Summed Pain Intensity Difference (SPID), the sum of the PIDs at a given hour. Results significantly favored naproxen sodium over placebo (p<0.05) at all times. Naproxen sodium was found to be well tolerated and was more efficacious than placebo in the treatment of muscle contraction headach

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803180.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISWe describe three patients with different forms of migraine in whom transcranial Doppler (TCD)showed prolonged diffuse vasospasm in the basal cerebral arteries when patients were asymptomatic. Vasospasm was more severe in one patient during her attack. These findings demonstrate the usefulness of TCD in evaluating vascular changes in patients with migraine.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803183.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThe results from three separate treatment studies on adolescents (N = 108) aged 16‐18 years with predominantly recurrent tension (n = 85), and migraine (n = 23) headaches are presented along with information on predictors of short‐term outcome. A standardized therapist‐or home‐based relaxation training program was compared to attention‐control approaches in which information or problem‐discussion procedures were provided for the students. These treatment conditions were both contrasted with self‐monitoring procedures. All students were assessed and treated in a school setting and may therefore, be regarded as representing a nonclinical replication series. The outcome results indicated that the majority (53%) of students, in particular those with tension headache, had improved after both forms of relaxation training, which were clearly superior to attention‐placebo control and self‐monitoring contrasts. Furthermore, it was found that treatment condition, baseline headache severity and students' satisfaction with their home life were the strongest predictors of overall outcome, accounting for 32% of the total variance. For students provided with relaxation training, a set of four parameters, again including baseline headache severity, in addition to students' level of somatic symptoms, school satisfaction and disease within their family, emerged as strong predictors of outcome, explaining 44% of the outcome variance. The results are discussed in view of similar outcome and prediction studies in the field of pediatric and adult r

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803187.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISA nasal spray preparation of salmon calcitonin (sCT) was administered to migrainous patients to evaluate the activity of sCT in migraine, and to better define its pharmacological profile. Twenty‐two patients with common migraine (CM) concluded a double‐blind, parallel trial versus placebo. A 30‐dayrun‐in period preceded a 3‐month period of therapy with sCT (200 UI at bed time), or with placebo. SCT was able to significantly reduce Headache Index, Pain Total Index (PTI) and analgesic consumption, from the first month of therapy. Another 10 patients suffering from migraine with interval headache (MIH) were admitted to an open study: a 10‐day run‐in period preceded a 30‐day phase of sCT (200 UI at bed time) administration. SCT induced a significant PTI reduction during the last 10‐days of treatment, while analgesic consumption improved significantly in the first ten days. Nociceptive flexion reflex threshold and plasma levels of β‐endorphin and β‐lipotropin, evaluated at the end of the run‐in and treatment periods to assess patients' antinociceptive state, did not change significantly. Our results demonstrate the effectiveness of sCT nasal spray preparation in treating migraine, and suggest a peculiar and complex pharmacological profile for sCT ranging from analgesic activity to modulation of the neuronal and neuro‐transmitter process

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803196.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISWe compared computerized EEG spectral measures in patients with common migraine, tension headache, complicated migraine, and normal controls. One minute summaries of 4 sec EEG epochs were recorded fromOz‐A1 + A2. Modal alpha frequency (MAF), the predominant frequency in the 8–13 Hz band, maximal alpha frequency (Mx AF), the fastest frequency in that band, and spectral edge frequency (SEF), the predominant frequency in the 13–30 Hz band, were calculated. EEG was also recorded from F3, F4, P3, P4, 01, and 02 with ear reference. Spectral mobility and first order complexity were compared in controls, migraineurs, and tension headache patients. Migraine and tension headache patients did not differ significantly, and were not different from control subjects in MAF and SEF. Complicated migraine patients had significantly lower MxAF than controls or common migraine patients (P<0.01). Patients with mixed element tension vascular headaches did not differ from controls in mobility or complexity at frontal, parietal or occipital sites. Mobility was significantly less at parietal and occipital sites in migraine patients (P<0.05). Complexity was less at both occipital electrodes(P<0.05) in the migraine group. Migraine patients had significantly lower occipital mobility and complexity scores than those with mixed element headaches (P<0.05).The findings suggest that computerized EEG analysis may help to categorize headache patients, and this may be therapeutically helpful. The time domain descriptors may be more sensitive to EEG differences than frequency or power measures. These observations suggest that migraine and mixed element headaches with amigrainous component may differ significantly in pathogenesis, and that central nervous system dysfunction may be involved in the pathogenesis of complicated migraine synd

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803201.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISBrainstem auditory evoked potentials (BAEPs) were recorded in pain‐free periods in 28 children suffering from migraine (23 common and 5 classic). They were without medication for at least one month before there cording session. The results were compared with a group of 10 normal subjects matched for sex and age. We found no significant differences between the migraine group and the control subjects; when analyzing separately the classic and common form, two groups either with more or less than 5 years of history of migraine or with and without nausea and/or vomiting, similar results were obtained. Our data suggest that in migrainous children conduction in the auditory pathway at the brainstem level is not significantly different from control

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803204.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISTwo patients with paranasal sinusitis, who showed cluster headache like symptoms rather than typical sinusitis symptoms, are reported. A possible mechanism of the cluster headache like symptoms is discussed. The importance of paranasal radiological study of patients with cluster headache like symptoms is emphasized. These cases seem to support a neuronal pathogenesis of the cluster headache syndrome.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803207.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISA case of a young woman suffering from both migraine and epilepsy is reported. Since the age of 28, she complained of classic migraine attacks and of generalized or partial seizures. The seizures often intercalated themselves between the visual prodrome and the painful phase of her attacks. She came to our observation at the age of 31. Neurological examination, laboratory work and CT‐scan were normal. The EEG showed an asymmetry of the background activity between the two hemispheres and medium‐voltage sharp waves, not blocking upon eye opening, in the left parieto‐temporel leads. Flunarizine was added to her anti‐convulsant therapy. It remarkably reduced the migraine attacks and controlled the intercalated seizures. After one year, flunarizine was discontinued and two intercalated seizures occurred four months later. The efficacy of flunarizine and its hypothetical mechanism of action in such a clinical condition is di

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803209.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThis study attempts to replicate and synthesize previous headache/MMPI research by investigating scale differences amongst diagnoses and between a control group; re‐examining the occurrence of the conversion “V” pattern; evaluating the Kudrow‐Sutkus (1979) classification system; measuring score changes which occur with prognosis; and observing the effect that “headache items” have on scale score elevations. Several mean scale scores differed from previous studies. A number of these differences were clinically significant. Analysis of variance (ANOVA) (sex [370 males and females] and headache diagnosis) for each scale determined that males had higher L scores; the control group had higher K scores than post trauma, mixed, or vascular patients; each headache diagnosis had higher 1, 2, 3, and 7 scores than the control group (scales 1, 2, and 3 were clinically elevated in only the post trauma and mixed conditions); scale 9 scores varied between conditions; and scale 10 scores were higher for migraine, mixed, cluster, and post trauma patients. Chi‐square analysis determined that the conversion “;V” pattern occurred in a significantly greater degree in headache patients. However, the percentage of occurrence ranged from only 12.50 to 31.03 percent. The Kudrow‐Sutkus system correctly diagnosed only 40.08 percent of 90 randomly selected subjects. One‐way ANOVA determined that no significant change occurred in group scale scores in 20 headache sufferers who received treatment ranging from a multi‐disciplinary hospital program to none at all and whose prognosis ranged from excellent to poor. One‐way ANOVA determined that the removal of items which inquire about “headache symptoms” produced significant reductions on scales 1 and 3.The inability of this study to replicate previous empirical investigations raises questions of the MMPI's reliability as a diagnostic classifier in chronic headache. Certain elevations on the MMPI may be the result of symptom measur

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1988.hed2803212.x

出版商:Blackwell Science Inc    

年代:1988

数据来源: WILEY