ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503173.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503177.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

摘要:

SYNOPSISThe effects of several drugs usually considered as serotonin (5HT) ‐antagonists were studied in a model of the external carotid circulation, the canine nasal vascular bed. 1. It was confirmed that 5‐HT constricts this vascular bed but that after administration of a large dose of ergotamine (10–2mg/kg i.v.), 5‐HT dilates the nasal vessels. 2. All drugs studied (Org GB 94, Org GC 94, ergotamine, dihydroergotamine, methysergide, pizotifen, cyproheptadine and clonidine) at relatively low concentrations can potentiate 5‐HT induced vasoconstriction. 3. At higher doses of these drugs the 5‐HT response is inhibited.4. The vasodilator response to 5‐HT obtained in erotamine‐treated dogs is inhibited by all other agen

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503180.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

摘要:

SYNOPSISSandler, Youdim and Hannington noted an inability to oxidise tyramine and phenylethylamene in dietary and non dietary migraine sufferers‐l,883 female volunteers in Britain completed questionnaires detailing food intake during the 24 hours prior to spontaneous migraine attacks. Analysis of 2,313 attacks are reported. This revealed consumption of chocolate in 33%, cheese 40%, citrus fruits 21% and alcohol 23%. Fasting (5 hours day or 13 hours overnight) occurred in 67%. No dietary factors were isolated in 5%. Only 14% thought food caused their attacks and 2% blamed fasting. Sensitising factors analysed included age, time in menstrual cycle, pill taking and hysterectomy. The findings suggest that in double blind trials designed to elucidate dietary factors, one needs to consider the patient's intake during the 24 hours prior to the administration of the test capsule. A new approach to treatment is suggested with elimination of specific foods and avoidance of fastin

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503188.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

摘要:

SYNOPSISThirty‐four patients with transient ischemic attacks (TIA) have been followed for 1 to 24 months. Twenty‐two patients had TIA in the anterior and 12 in the posterior circulation. Episodic and late onset vascular headaches occurred. Four patients had episodic headaches, 7 patients had late onset vascular headaches and 11 patients had both types of headaches. Episodic headaches preceded, occurred during, or immediately after TIA. These headaches were present in 15 of the patients (44%). Late onset vascular headaches started in middle or late life, occurred independently of TIA and were observed in 18 patients (52.9%). In 13 patients the headaches began 1 month to 15 years prior to TIA and in 5 cases, 2 days to 1year after the onset of TIA. Late onset vascular headaches preceded TIA in 38.2% of patients. These headaches might be of prognostic significance in some patients for the development of TIA and str

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503194.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

摘要:

SYNOPSISSeventy‐two records of patient with systemic lupus erythematosus were reviewed retrospectively. Sixty‐one fulfilled the criteria for the disease. Forty‐six percent had clinical evidence of central nervous system involvement. The incidence of headache was compared in those with and without central nervous system lupus. No difference in the frequency of headache in the two groups were found and the incidence of hypertension, renal disease and steroid therapy was equally distributed among those with and without headache. A significantly higher incidence of hypertension was found in patients with central nervous system lupus erythematosus. We conclude that headache in systemic lupus erythematosus in the absence of neurologic symptoms or signs is no indication of central nervous system involvement by the process and that small vessel disease of the brain is not a cause of hea

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503198.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

摘要:

SYNOPSISClonidine was evaluated in the prophylactic treatment of migraine. The results were compared with those obtained with placebo in the same patients.Identical protocols were used at headache centers in St. Louis and Chicago. There were similar results though evaluations were completely independent.Clonidine was not superior to placebo in preventing migraine attacks.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503202.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

摘要:

SYNOPSISA woman developed severe recurrent headache associated with transient neurologic dysfunction while recuperating from carotid endarterectomy performed for transient ischemic attacks. She had severe carotidstenosis preoperatively, but when studied during the period of severe headache had an angiographically normal carotid artery territory. The headaches and neurologic dysfunction appeared after a postoperative headache free period of 72 hours, were self limited, and had characteristics of migraine. Migrainous post‐endarterectomy headache may be a manifestation of disordered autoregulation of cerebral blood flo

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503207.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

摘要:

SYNOPSISThirty‐six patients participated in a double‐blind, two‐way crossover study of isometheptene (Octin) and placebo. Seventeen had a better response on isometheptene than on placebo. Placebo was superior to isometheptene in eight cases. Of 72 courses of treatment with each drug, isometheptene produced good or complete relief of pain in 30 courses of treatment (42%) while placebo produced a similar response in 21courses of treatment (29%) (p<0.05). When the severity of pain and the degree of relief were considered, the superiority of isometheptene did not reach statistical significance at the 5% level. Side effects due to isometheptene were few and mild or of moderate severity. Isometheptene may be an alternative treatment when ergotamine is contraindi

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed1503211.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1975.hed15003214.x

出版商:Blackwell Science Inc    

年代:1975

数据来源: WILEY