ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00403.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00404.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The interaction of catecholamines and drugs with adrenergic receptors leads to a set of biochemical reactions which ultimately results in a physiological response. A brief review is given of the classification of adrenergic receptors into subtypes and the use of ligand binding techniques for the identification and characterization of these receptors. Recent advances in the biochemistry of adrenergic receptors are reviewed with special reference to the interaction of the βand α2–receptors with guanine nucleotide regulatory proteins and adenylate cyclase. The role of calcium and phos–phoinositides in the function of the α1–receptor is also d

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00405.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00406.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00407.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00408.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00409.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Single doses of labetalol (200 mg i.v. over 5 min, 200 and 400 mg orally) were given to five helthy men on three different occasions. Plasma levels were followed for up to 25 h and blood pressure for 5 h.The elimination half–life was 1.6 to 8.5 h for the first 8 h. The oral bioavailability ranged from 4 to 23%. All doses induced a significant fall in systolic blood pressure at 2 h, the peak effect occurring at 30–120 (mean 63–72) min. After intravenous administration the peak supine blood–pressure fall was significant for both systolic and diastolic blood pressure and occurred 16 min after adminis

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00410.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Since sympathetic nervous activity is intimately involved in the regulation of hormonal and metabolic responses, it may be assumed that antihypertensive drugs acting on adrenergic receptors will interfere with metabolic control mechanisms.We have therefore evaluated the effect of the selective α1–adrenoceptor blocker prazosin on intravenous glucose tolerance and insulin response in a group of 6 healthy subjects. Ninety minutes after a single oral dose of 2 mg prazosin we observed a significant (p<0.05) fall in K–value (mean decrease from 1.7 to 1.0), which was accompanied by a blunting of the early insulin response. The acute effects of prazosin closely resemble those observed after 6–8 weeks of treatment with therapeutic doses of prazosin in hypertensive women. It is postulated that the effect of prazosin is mediated by an increase in circulating catecholamines acting on the pancreatic β–cell α2–adrenoceptors, which are responsible for the wellknown inhibitory action af α–adrenergic agents upon the rel

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00411.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.In early essential hypertension, an increase in cardiac output (CO) is seen in about twothirds of the patients. In established essential hypertension, CO is usually normal or subnormal, while total peripheral resistance (TPR) is increased.Treatment with β–adrenergic blocking agents accentuates these haemodynamic changes; in particular CO is further decreased. Comparison of the effects of β–blockers with and without β1–selectivity and instrinsic activity reveals slight differences in the haemodynamic responses. Although none of the β–blockers normalizes the haemodynamics, satisfactory blood–pressure reduction may be achieved at rest and during exercise with minimal

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb00412.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY