ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01974.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.A comparative analysis of the usage of analgesics in the county of Jämtland and in Sweden 1970–78 has been carried out. An attempt was also made to map out the indications for prescribing such drugs. Both in Jämtland and in Sweden as a whole, analgesics sold over the counter accounted for more than half of the total usage. The same was true for fixed drug combinations. Analgesics were prescribed each year to 17% of the population of Jämtland. Fixed drug combinations containing sedatives maintained a large fraction of the amount of analgesics prescribed—31% of defined daily doses (DDDs) in 1978. Arylalkanoic acids (ibuprofen and naproxen), introduced in 1975, soon took a substantial part of the market—13% of DDDs in 1978. Though arylalkanoic acids were registered for treatment of degenerative joint diseases, four of five patients in Jämtland received them only once or twice during a two‐year period. In the national study, every third prescription of these drugs was for degenerative joint diseases. The pattern of usage revealed in this study calls for improved pharmacotherapeutic training of physicians to make drug treatment mo

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01975.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The contribution of bone scintigraphy to the diagnosis of skeletal involvement in multiple myeloma was evaluated in a consecutive, unselected series of 25 previously untreated patients. Definite scintigraphic abnormalities were found in 11 patients (localized in 4, generalized in 7) (44%). In the majority of patients the clinical value of the information gained from scintigraphy was roughly equal to that found by radiography. However, 2 patients with normal and 2 with questionable bone scans had X‐ray evidence of skeletal involvement, and the extent of bone destruction in 4 cases was seriously underestimated in the bone scans. Small osteolytic lesions were as a rule not detected by scintigraphy. On the other hand, in 8 patients the bone scan added information of involvement of ribs, pelvis and vertebrae, not clearly visualized by X‐ray. In 2 patients, both with IgA myeloma, hypercalcemia and uremia, a massive extraskeletal uptake of the bone‐seeking isotope was observed. Autopsy verified in one case the presence of a disseminated metastatic calcific

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01976.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.In 16 patients with mitral stenosis (MS), alone or in combination with either mitral insufficiency (2 pats.) or aortic valve disease (3 pats.), the mean diastolic pressure gradients across the mitral valve calculated by Doppler ultrasound were significantly correlated to the catheterization data. The average mean pressure drop by Doppler was 11.8 mmHg and by catheterization at rest 16.7 mmHg. A significant correlation between gradients was also found in 5 patients who exercised supine on a bicycle. Atrioventricular pressure half‐time (T1/2), i.e. the time during which the pressure drops from the peak value to half of its initial value by the Doppler technique, was significantly correlated to mitral valve area (MVA) determined from catheterization data. IncreasingT1/2 reflected decreasing MVA. It is concluded that Doppler ultrasound is a useful method in the evaluation of patients with M

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01977.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.In the Stockholm Prospective Study, 531 male and 163 female deaths had occurred during 14.5 years of observation. Deaths were divided into three categories: “ischemic”, “neoplastic” and “other” and their relations to entry characteristics were analyzed. Forischemic vascular deathsage, smoking, systolic blood pressure and triglycerides were independent risk factors for both sexes, while cholesterol and weight/height index were not. Forneoplastic deathsage, smoking, systolic blood pressure and ESR were positively and cholesterol and weight/height index negatively associated. This negative association was found especially for colon carcinoma and not for, e.g., prostatic and bronchial carcinoma in men. Forother deathsage, blood pressure and ESR were independent risk factors for men, and age, smoking and ES

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01978.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Blood flow resistance was studied in two peripheral vascular beds in 15 patients with previous malignant hypertension and in matched groups of patients with “benign” hypertension and control subjects. Both hypertensive groups had significantly higher resistance in the hands (skin vessel bed) at maximal dilatation (2.5 and 2.5 U, respectively) than the normotensive group (1.9 U) (p<0.01). This increase indicates structural changes in the arteriolar wall in both hypertensive groups. It indicates a similar degree of adaptation of the vascular changes to the present blood pressure level in both hypertensive groups, although the initial blood pressure had been much higher in the group with previous malignant hypertension than in the group with “benign” hypertension. Different findings were made in the calves (muscle vessel bed), and the most severe changes were found in patients with previous malignant hypertension. Resistance at maximal dilatation was 2.4 U compared to 1.9 U in the group with “benign” hypertension (p<0.05) and 1.6 U in the control group (p<0.001 andp<0.05, re

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01979.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The effect of long‐term β‐adrenergic blockade on plasma lipids and lipoproteins was studied in 68 consecutive patients enrolled in a double‐blind controlled trial of alprenolol in myocardial infarction. Thirty‐three patients were treated with 200 mg alprenolol twice daily for one year, and 35 patients received placebo. Neither plasma cholesterol, plasma triglycerides nor plasma lipoproteins were significantly influenced by al

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01980.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.In a retrospective study the incidence of AMI and death after discharge from CCU have been recorded in 67 patients with and 93 without a diagnosis of AMI confirmed in the CCU. No statistically significant differences were found between the two groups in mortality rate during the first 3 years, 18.3% (non‐AMI) and 22.4% (AMI), or in cardiac events, sudden death and AMI, 19.3% (non‐AMI) and 24.9% (AMI), during the first 2 years after discharge. Non‐AMI patients with either previous AMI, angina pectoris or ST‐T abnormalities in the ECG accounted for the major part of cardiac events in this group. The mortality rates in the two groups, compared to a normal population matched for sex and age, were in the AMI group in the 1st year 13.4 and 2.6% (p0.05) and in the non‐AMI group in the 1st year 11.8 and 1.8% (p0.05). It is concluded that the prognosis after discharge from the CCU is as unfavourable for patients without as for patients with AMI. The mortality is highest during the first 6–12 months afte

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01981.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The relationship between diabetes mellitus and the exocrine pancreatic function was evaluated in 29 patients with insulin‐dependent diabetes mellitus by measuring cathodic trypsin‐like immunoreactivity (TLI) and the enzymatic activity of pancreatic isoamylase in serum before and 90 min after breakfast and insulin. Thirty healthy subjects served as reference group. Median fasting serum concentrations in the diabetic subjects were significantly lower than in the reference subjects: for TLI 143 and 299 μg trypsin standard/I and for pancreatic isoamylase 43 and 101 U/I, respectively (p<0.001 for both). A positive correlation between TLI and pancreatic isoamylase was present in the diabetics (Sperman's rho=0.56,p<0.01). The serum concentrations of TLI and pancreatic isoamylase were not related to the duration of diabetes, daily insulin dose or glycemic control measured by blood glucose and total glycosylated hemoglobins. Cathodic TLI and pancreatic isoamylase in serum were not influenced by food and ins

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01982.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Neutrophil granulocyte chemotaxis and intraneutrophilic and plasma levels of lysozyme as well as the number of T and B lymphocytes and lymphocyte transformation in vitro on stimulation with mitogens and microbial antigens were studied in four groups of patients with diabetes mellitus (DM). Twelve patients with insulin‐dependent diabetes mellitus (IDDM) and ketoacidosis and 4 patients with non‐insulin‐dependent diabetes mellitus were studied at the time of diagnosis and before and after start of treatment. Ten patients with IDDM of less than 10 years' duration which had been difficult to regulate well and 10 patients with IDDM well regulated for more than 20 years were studied at their regular outpatient visits. Apart from a slight increase in plasma lysozyme in group 1 from the first to the second examination, we found no differences between diabetics and healthy control persons. It is concluded that if patients with DM are more susceptible to infections, it is probably caused by elements of neutrophil or lymphocyte function not examined in this study or by factors unrelated to imm

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01983.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY