ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15645.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTIn two patients (father and daughter) with idiopathic hypoparathyroidism, one of whom was resistant to the action of vitamin D2and AT‐10, lα‐hydroxycholecalciferol (lα‐(OH)D3) in doses of 2–5 μ//day restored the serum calcium concentration to the normal range. The calcemic effect of 1α‐(OH)D3was in both patients due to an increased intestinal calcium absorption and increased calcium mobilization from bone. In one of the patients 1α‐(OH)D3also increased the renal tubular calcium reabsorption; in the other it did not have this effect, resulting in hypercalciuria as serum calcium rose. The lack of effect on tubular calcium reabsorption probably accounts for the relative resistance to the action of lα‐(OH)D3in this patient comp

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15646.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTVarious approaches to the study of physiological and behavioural effects of energy deprivation are presented and discussed. An experimental, total energy deprivation in 20 healthy human volunteers during an 11‐day period, preceded and followed by 4‐day control periods, is described. Potentially pathogenic reactions which occurred in spite of precautions are analysed. It is concluded that the present controlled real‐life model with acute total energy deprivation serves the purpose of studying hypotheses concerning potentially pathogenic mechanisms occurring in deprivational situations under conditions of natural and man‐made catas

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15647.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTTen days of total energy deprivation evoked the following endocrine changes in 12 healthy, normal‐weight males: early and marked reductions and increments in the blood levels of T3and reverse T3, respectively, with rapid returns to pre‐starvation levels after refeeding; a slight and late decrease in the blood levels of T4; a minute reduction of the blood levels of TSH; a pronounced increase in the blood levels of growth hormone, but a return towards preexposure levels even before discontinuation of starving; a minor and gradual enhancement of the blood levels of cortisol, and an increase in nocturnal urinary adrenaline excretion. It is assumed that these changes reflect a complex regulatory mechanism, the purpose of which is to secure adequate energy supply to vital org

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15648.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTSerum values for calcium, phosphate and albumin have been determined in a population study of 2 322 49–50‐year‐old men participating in a health examination survey. Calcium and albumin were significantly correlated (r=0.34) but adjustment for albumin only caused minor effects on the distribution of calcium. No inverse relationship was found between calcium and phosphate. Seasonal variations over the three years of the health survey could not be established for either calcium or phosphate, whereas there was a slight tendency for albumin to decline during summer. The prevalence of hyperparathyroidism (HPT) in this population of men up to the age of 50 was 0.3% and among those with recurrent renal stones 5.3%. All subjects with verified HPT had a history of recurrent renal stones. One man on thiazide treatment had a slight elevation of calcium which returned to normal after cessation of the drug. No other case of hypercalcemia besides those caused by HPT was found. Mean values and frequency distributions for calcium, phosphate and albumin were almost identical in renal stone formers and matched controls. Hence it seems likely that other factors than those which markedly affect serum levels of calcium and phosphate are of major importance in common renal stone form

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15649.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTSerum lipids, blood pressure, and magnesium levels in serum and erythrocytes have been measured in 73 men and women, aged 60. The purpose was to evaluate the relationship between the serum and erythrocyte magnesium and indicators of ischaemic heart disease. The results showed significant inverse correlations between serum magnesium levels and PB, and positive significant correlation between erythrocyte magnesium and serum cholesterol.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15650.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTHypercalcemia after renal transplantation (post‐T hypercalcemia) has been detected in 29 (16.7%) of 174 long‐term survivors. The mean time of onset of hypercalcemia was 69 days after renal transplantation (range 3–210). In 18 patients the hypercalcemia was mild and resolved spontaneously (transient) from 2–65 months (mean 19) after onset. In 4 patients serum calcium normalized concurrently with rejection episodes. In 7 patients the hypercalcemia was more pronounced (permanent), being terminated by subtotal parathyroidectomy in 5 and persisting in 2 recipients. The hypercalcemia was asymptomatic except in one patient, who developed calculi in the graft and a fall in graft function, all of which disappeared after parathyroidectomy. At operation the parathyroid glands showed hyperplasia, except in one case with an adenoma in one of the hyperplastic glands. Serum phosphorus was markedly decreased, to the same extent in transiently and permanently hypercalcemic recipients. Serum parathyroid hormone (S‐PTH) was increased in all of 5 patients with permanent and in 3 of 8 with transient post‐T hypercalcemia. In normocalcemic and in transiently hypercalcemic recipients the mean S‐PTH was identical, but significantly lower than in the permanently hypercalcemic recipients. S‐PTH was suppressed to the same extent during an i.v. calcium in fusion in patients with post‐T hypercalcemia and with primary hy

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15651.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe bioavailability of 6‐propylthiouracil (PTU) has been examined in eight healthy volunteers, with respect to interindividual variation and influence of food intake. PTU was given as a single oral dose, both in a fasting state and together with a standardized breakfast. Numerous venous blood samples were taken during 5 hours after PTU ingestion, and the concentration of unmetabolized PTU in serum was determined by a specific gas‐chromatographic technique. The observations indicate that the amount of PTU absorbed is subject to a large interindividual variation, and that concomitant food intake may exert a minor and non‐systematic influence on PTU absorption. Hence, the major issue in PTU therapy is the individualization of the size and interval of dosage. Testing of single‐dose PTU kinetics in patients would apparently be

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15652.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTIn seven normocalcemic subjects, fasted for 48 hours, alcohol hypoglycemia has been accompanied by a significant decline in basal insulin secretion. In another six healthy subjects, fasted for two days, infusion of calcium also induced a significant fall in basal secretion of insulin. However, when six healthy volunteers, fasted for two days, were infused with calcium and given alcohol simultaneously, no significant fall in insulin was recorded, even though the hypoglycemia, following this combined load, was of the same magnitude as in the subjects given alcohol alone. The implications of these findings are discussed.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15653.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

ABSTRACTThe serum concentration of bilirubin and the activities of aspartate aminotransferase (ASAT, GOT), alanine aminotransferase (ALAT, GPT), γ‐glutamyltransferase (GT), total amylase and pancreatic isoamylase have been determined in serum of 182 male chronic alcoholics. Twelve per cent had abnormally high levels of bilirubin, 73% increased activity of S‐ASAT, 50% increased S‐ALAT, and 69% increased S‐GT. The highest values were often found after 5–20 years of well documented alcoholism. Some patients with alcoholism of more than 20 years' duration displayed a slight tendency towards normalization of the activities. For all parameters the scatter around the mean was greater in the patients than in the controls. Patients who had had attacks of delirium showed slightly higher S‐ASAT and S‐ALAT than other alcoholics. Determination of S‐ALAT and S‐bilirubin did not add to the cases with abnormal laboratory tests demonstrated by the combination of S‐ASAT and S‐GT. In 14 patients the above mentioned parameters were within normal limits, even though severe alcoholism had lasted for many years. Isoamylase determination disclosed 20% to have decreased activity of pancreatic isoamylases in serum, whereas only 6% had low total

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1977.tb15654.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY