ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01955.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The purpose of this study was to assess the predictive values of the assays of fibrinopeptide A (FPA), β‐thromboglobulin (BTG) and their combination in patients suspected of having acute deep venous thrombosis (DVT) or pulmonary embolism (PE). In 80 controls the mean (± SD) plasma concentrations of FPA and BTG were 0.72±0.47 and 28.2±10.1 ng/ml, respectively. In 26 patients, in whom DVT was confirmed by phlebography and Doppler ultrasound, clearly raised mean FPA (5.62 ng/ml) and BTG (70.6 ng/ml) concentrations were measured compared to those in 13 patients in whom this disorder was excluded (1.00 and 33.6 ng/ml, respectively). Also in 25 patients, in whom PE was established by perfusion lung scanning, clearly increased mean FPA (6.28 ng/ml) and BTG (82.4 ng/ml) concentrations were measured compared to those in 12 patients without this disease (1.03 and 32.5 ng/ml, respectively). Raised FPA and BTG concentrations were also found in 20 patients with inflammatory disorders and in 10 with various types of malignancy. The mean FPA and BTG concentrations did not differ between patients with renal failure or diabetes mellitus and patients without these diseases. From the predictive values of these assays and their combination it can be concluded that raised FPA and BTG concentrations are not specific for thrombosis. However, when normal FPA and BTG concentrations are present, acute DVT or PE can safely be excluded in symptomatic patients. In the group with confirmed DVT/PE, anticoagulant treatment (heparin and phenprocoumon) brought down the mean FPA concentration to levels within the normal range in less than 1 hour while the mean BTG concentration remained elevated throughout the 10‐day study

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01956.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The effect of long‐term cimetidine treatment for 6 months on basal and thyrotropin‐releasing hormone (TRH)‐stimulated prolactin (PRL) and thyroid‐stimulating hormone (TSH) secretion was studied in eight male patients with duodenal ulcer. They received 1000 mg cimetidine orally per day until ulcer healing and thereafter 400 mg daily for the remaining period. TRH perturbation tests were performed before and after the 6 months of treatment. A significant reduction in the pituitary TSH response capacity was found. No significant changes in basal and TRH‐stimulated PRL, basal TSH, thyroxine and triiodothyronine were found. It is uncertain if the reduction in pituitary TSH response capacity has any clinical implications in euthyroid

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01957.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.To assess the cellular effects of digoxin, intraerythrocytic sodium and potassium concentrations were measured in 17 patients during the early phase of digitalization, in 45 patients on long‐term therapy and in 64 non‐digitalized control patients. Acute digitalization raised intraerythrocytic sodium from 11.6±0.4 to 16.7±1.0 mmol/1 (mean ± SEM) (p<0.01) and reduced intraerythrocytic potassium from 100.1 ±1.3 to 95.9±1.8 mmol/1 (p<0.01). These changes were strongly correlated with the steady‐state plasma digoxin concentration. During a few weeks of digoxin therapy, the intraerythrocytic cation composition normalized gradually. In patients on chronic treatment, neither intraerythrocytic sodium (11.3±0.3 mmol/1) nor potassium concentrations (100.0±0.6 mmol/1) differed significantly from the values of the control group (11.4±0.2 and 99.9±0.5 mmol/1, respectively). The changes in intraerythrocytic cation concentrations, induced by acute digitalization, seem to disappear during chronic administrati

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01958.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Serum levels of amyloid P‐component (SAP) and C‐reactive protein (CRP) were determined in 260 asymptomatic Icelanders of both sexes and various age groups and in 60 members of a family with macroglobulinaemia. In the normal group the SAP levels were normally distributed but slightly higher than in a comparable British group. Elevated levels of SAP and CRP were found in four elderly sibs of the macroglobulinaemia family. Two of them had benign monoclonal macroglobulinaemia (BMM), one had Waldenström's macroglobulinaemia and one increased polyclonal IgA. In addition, a notable small increase (2–20 μg/ml) in the levels of CRP was found in 6 children and 3 grandchildren of two elderly sibs with BMM. This increase in serum CRP levels was also found in five of six family members when investigated four years later. The HLA haplo‐types present in the family members, including B7, are not closely associated with the various abnormal protein changes detected in the elderly sibs of the second generation or their descendents. Likewise, the increased levels of SAP, CRP or IgM are not associated with any particular type of the genetic protein markers or blood group syste

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01959.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Daily measurements of serum creatine kinase (CK) activity have been performed in 31 patients during hospitalization for acute myocardial infarction (MI). If CK was raised, isoenzyme B was analysed as well. In this way one probable silent MI and another two overt MIs were diagnosed. MI recurred within three months after discharge in another five patients. None of these eight patients showed even small increases in the daily CK activity when in hospital. This study does not support the concept that reinfarction is a stepwise damage of the myocardium.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01960.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The relationship between blood pressure (BP) and the renin—angiotensin—aldosterone system was studied in a stratified random sample (n= 120) of 49‐year‐old men selected from a BP screening and covering a wide range of BPs. Only subjects not on antihypertensive treatment were included. None had malignant or secondary hypertension. Plasma renin activity, plasma concentrations of angiotensin II, aldosterone, sodium, potassium and noradrenaline and the 24‐hour urinary excretions of sodium, cortisol and noradrenaline were determined. Of these variables, only p‐aldosterone was significantly correlated with BP, both in the whole study group (R=0.22,p<0.02,n= 119) and in the subjects with the highest BP range (R=0.36,p<0.02,n=30). Of the clinical groups compared, the hypertensive subjects had significantly higher mean p‐aldosterone than the borderline and normo‐tensive subjects. Multiple regression analysis showed that the 24‐hour urinary excretion of noradrenaline was the factor most strongly correlated to p‐aldosterone, suggesting that the sympathetic nervous system might stimulate aldosterone secretion. Our findings indicate that aldosterone may be of importance for the development and maintenance of ess

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01961.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The serum concentrations and clinical effects of sulfaisodimidine given during 12 days were examined in two groups of patients with uncomplicated lower urinary tract infection. Group I (n= 12) received the drug in a conventional dosage, 1 g four times daily, and group II (n= 14) in a dose of 2 g twice daily. The serum concentrations of sulfonamide at steady state (day 7) and one day after cessation of therapy (day 13) did not differ significantly between the groups. With the exception of one patient in group I, both subjective and objective symptoms vanished during treatment and remained absent for at least 4 weeks thereafter. Two patients in each group developed signs of sulfonamide allergy. Thus, the two regimens seemed to be equally efficient, and the risk of therapy failure due to low blood concentrations of sulfaisodimidine should not be greater when the drug is given in a dosage of 2 g twice daily than when it is administered in the conventional way. Hence, the latter, simpler regimen can be recommended.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01962.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The diagnostic efficiency of99Tcm‐plasmin test was evaluated by X‐ray contrast phlebography in 110 consecutive patients with suspected deep vein thrombosis (DVT). The test was positive in 50 of 55 patients with DVT (sensitivity 91%) and negative in 18 of 55 without DVT (specificity 33%). The positive plasmin test in patients without DVT was in most cases due to another inflammatory process or a post‐thrombotic state. The99Tcm‐plasmin test is a rapid and sensitive screening method for the diagnosis of DVT, but as it is based on comparison between the legs, it may be unreliable in cases of bilateral thrombosis. The low specificity makes it less valuable in patients with concomitant inflammatory disease or previous thrombosis in either leg. When the plasmin test is positive, the diagnosis of DVT should in most cases be confirmed by X‐ray contrast phl

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01963.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Autonomic neuropathy (AN) test results (Valsalva manoeuvre, deep breathing, and tilting) are frequently impaired in diabetics without symptoms of AN, particularly in those with peripheral neuropathy (PN). We have investigated 24 asymptomatic diabetics with PN, 17 diabetics with symptoms of AN and 24 healthy controls. The heart rate reactions to the three tests were impaired in both patient groups. The Valsalva manoeuvre could not distinguish between the patient groups. The heart rate reaction to deep breathing, estimated as the expiration/inspiration (E/I) ratio, was slightly more disturbed in patients with AN than in those with PN (1.04 vs. 1.09,p<0.05) but the frequency of abnormally low E/I ratios was high in both groups (76.5 vs. 54.2%, NS). The immediate heart rate reaction to tilting, estimated as the brake index, clearly separated the patient groups. An abnormally low brake index was shown in 82.3% of AN patients and in 33.3% of PN patients (p<0.01). The study shows that the deep breathing test is sensitive for AN but an impaired immediate heart rate reaction to tilting is more specific for symptomatic AN.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01964.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY