ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08605.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.Fibrinolytic activity in plasma after venous occlusion was determined on two consecutive days 1–5 years after an acute myocardial infarction sustained before the age of 60 years in a group of 66 non‐diabetic men with normal serum cholesterol levels, and in an age‐ and sex‐matched reference group of 32 men. The infarction group was divided into 2 subgroups: one with normal (n= 42), the other with elevated (n= 24) diastolic blood pressure. Variance analysis did not reveal any statistically significant differences in fibrinolytic activity after repeated provocation between the three groups, but in a Student's test the value was significantly lower in the infarction group with high diastolic pressure than in the reference group. A relationship was found between apolipoprotein AI and fibrinolytic activity after repeated prov

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08606.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.A prospective clinical study of 66 geriatric in‐patients mainly on digoxin treatment revealed digitalis intoxication in seven (11%). Over a two‐month period another patient developed digoxin toxicity. The prevalences of anorexia, nausea and vomiting were significantly higher in patients with than without digitalis toxicity. The mean serum drug concentration was significantly higher in overdosed than in non‐overdosed patients, but six patients had serum digoxin concentrations within or below the therapeutic range, and only two slightly above. Notably, maintenance digoxin therapy was unnecessary in five out of eight intoxicated patients. The value of determining serum digitalis concentrations in diagnosing clinical toxicity in geriatric in‐patients is di

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08607.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.The effects of oral digoxin and placebo in 41 geriatric in‐patients were compared using a randomized, double‐blind, cross‐over method. The patients were in sinus rhythm or had atrial fibrillation. The observation period was two months on digoxin or placebo. Patients with symptoms of cardiac failure at rest or during light physical activity, X‐ray signs of pulmonary congestion, proven need of digoxin therapy following earlier withdrawal, atrial fibrillation with a ventricular rate>95 beats/min and patients in whom digitalis intoxication was suspected were excluded from the study. Five (14%) of 37 patients deteriorated during the placebo phase. Four of these developed rapid atrial fibrillation and one patient developed sinus tachycardia and symptoms of heart

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08608.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.The elderly female population living in a rural primary health care district in the south of Sweden was screened for hypo‐ and hyperthyroidism. A total of 1 442 (97.3 %) of the 1 482 women 60 years of age or older attended the study. By use of a computer‐evaluated thyroid hormone panel, 178 women (12.3%) were identified as probably abnormal. Among them, 8 women (0.55% of total) with previously unknown thyroid disease were detected as overtly hypothyroid. If also 13 women with spontaneous subclinical hypothyroidism were included, the prevalence of earlier unknown hypothyroidism was 21/1 442 (1.5%). The number of subjects with hyperthyroidism discovered by screening was 28/1 442 (1.9%). Although much remains to be elucidated regarding medical, social and economic factors, the high figures obtained for newly discovered abnormal thyroid function suggest that screening for hyper‐ and hypothyroidism may be worthwhile in such an elderly female popul

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08609.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.In 19 men aged 50 with essential hypertension, 18 weeks' treatment with atenolol (n=9) or oxprenolol (n=10) increased supine plasma free dopamine concentrations by 78% (p<0.05) and 121 % (p<0.001) respectively. Increments in plasma dopamine were observed in all patients except for one treated with atenolol. Supine peripheral venous adrenaline and noradrenaline concentrations were not influenced by β‐blockade. The mechanism and significance of the present elevation of plasma free dopamine by β‐blockade are unknown. However, increased plasma free dopamine may be involved in the hypotensive effect of chronic β‐adrenergic blockade, both β‐1 selective and non‐selective, and may lend further support to decreased dopaminergic activity in essential

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08610.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.Despite the short plasma half‐life of hydralazine, once daily Slow Apresoline has been shown to maintain blood pressure control in well controlled hypertension. In the present investigation of 118 inadequately controlled hypertensives, we have shown that 50–150 mg Slow Apresoline once daily induces a significant blood pressure reduction and is well tolerated. Normotension, i.e. supine diastolic blood pressure<95 mmHg, was reached in 53 % of the patients. Normotension or a supine diastolic blood pressure reduction of ≥10 mmHg was achieved in 72% of the patients, the hydralazine responders. Sixteen patients discontinued treatment due to symptoms probably related to hydralazine. Acetylator phenotyping showed that slow acetylators predominated in the group of patients discontinuing hydralazine due to side‐effects. In contrast, 90% of the phenotyped non‐responders were rapid acetylators, which suggests a suboptimal use of hydralazine in some rapid ac

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08611.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.In a cross‐over study of 52 middle‐aged patients with mild to moderate essential hypertension, we have compared the effect and tolerability of 100 mg atenolol and 100 mg metoprolol given once daily. After 1 1/2 and 3 months of treatment, both systolic and diastolic blood pressure 24 hours after drug intake were significantly lower on atenolol. There were no significant differences after 3 months when blood pressure was read 3–4 hours after dose intake. During exercise, systolic blood pressure and heart rate were—at all work‐loads—significantly lower on atenolol. Four patients on metoprolol and one patient on atenolol discontinued treatment owing to side‐effects. The results support the need for thorough analysis of the duration of action and influence of physical activity and sympathetic tone in comparisons between presumedly equivalent antihyper

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08612.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.In a longitudinal study, 21 patients with familial amyloidosis with polyneuropathy (FAP) were followed up for more than three years. Gastrointestinal symptoms ultimately evolved in all patients. In the advanced stage of the disease, 13 patients had diarrhea together with anal incontinence. Weight loss was very common and related to both malabsorption and motility disturbances with anorexia and also to muscular atrophy. Steatorrhea was found in 19 patients at least once during the follow‐up. The duration of the disease was significantly correlated to fecal fat output. The conclusion was drawn that the gastrointestinal involvement in FAP is very common and of great clinical importance. The consequences of malnutrition also influence the outcome of the diseas

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08613.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACT.The effects of delayed cutaneous hypersensitivity (DCH) testing (Multitest, Institute Mérieux) on lymphocyte counts and functions were studied in seven healthy women. All had normal DCH responses and lymphocyte functions. No influence of the DCH testing on subsequent tests for lymphocyte subpopulations and mitogen‐ and antigen‐induced DNA synthesis was observed. The PPD skin test did not boost or otherwise alter the in vitro lymphocyte response to PPD. It may be concluded that Multitest is a simple way of assessing DCH and that this test does not interfere with repeated in vitro tests of lymphocyte capa

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb08614.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY