摘要:

ABSTRACT.A search of the literature revealed a paucity of data on reference values for clinical chemical and haematological quantities in reasonably ‘healthy’ ambulant persons above 65 years of age. On the basis of 90 papers, concerning 37 different types of quantities, the median values for men and for women at 30, 50, 65, and 80 years are calculated relative to the value in men at 30 years. This transformation reduces influences of analytical and demographic factors that have caused considerable systematic differences in the original data. The reference distribution is described as regards symmetry and the change in dispersion with age. The results are given in a table and show four types of changes with age: no significant variation, a fall, an increase or a maximum somewhere between 30 and 80 years; the type of change often depends on

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11542.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11543.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.Factor VIII clotting activity (VIII: C) and factor VIII clotting antigen (VIII: CAg) were investigated in 54 patients with hemophilia A of moderate or mild severity. The patients belonged to 28 kindreds. The study showed a genetically determined molecular variation within hemophilia A of both moderate and mild forms. Each form can be classified into 3 types according to the content of demonstrable VIII: CAg. Type I has no demonstrable VIII: CAg, type IIa has VIII: CAg in an amount smaller than, or approximately equal to, that of VIII: C and type IIb has a larger amount of VIII:CAg than VIII:C. Affected members of one and the same kindred always have the same type of the disease.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11544.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.Twenty patients with osteosarcoma were treated with exogenous human leukocyte interferon for periods ranging from 6 to 18 months. Eleven of them remained free from detectable tumour growth during this treatment. Blood samples from all patients were tested for antibodies against interferon and against impurities in the interferon preparations. No patient developed detectable levels of neutralizing antibodies against interferon. All patients formed antibodies against contaminants in the concentrated crude interferon and the partially purified interferon preparation which had been used for treatment.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11545.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.Two hundred and twenty‐one adult patients were splenectomized for various hematologic disorders, including immunologic thrombocytopenia (80 cases), hereditary spherocytosis (15 cases), autoimmune hemolytic anemia (20 cases) chronic lymphatic leukemia (27 cases), lymphosarcoma (27 cases), myelofibrosis (11 cases) and pancytopenia/aplastic anemia (14 cases). Complete and lasting remission was achieved by 72 % of patients with immunologic thrombocytopenia and by 60% of patients with autoimmune hemolytic anemia. Improvement was seen in 74 % of patients with lymphosarcoma, in 55% of those with chronic lymphatic leukemia and in 63 % of those with myelofibrosis, whereas only one of 14 patients with pancytopenia/aplastic anemia had any benefit of splenectomy. Of 8 postoperative deaths (3.6 %), 6 were caused by septicemia and 2 by hemorrhage. Non‐fatal complications, mainly infections and hemorrhages, occurred in 49 patients (22 %) and were most frequent in cases with massive splenomegaly (>1000 g) or severe thrombocytopenia (<20 × 109/l). Also, more complications occurred in chronic lymphatic leukemia and myelofibrosis than in other diseases. Late postsplenectomy fulminant infection was seen in 8 patients (3.6%), the type of infection being septicemia in 6 and meningitis in 2, and 6 of them died. We conclude that splenectomy is often of considerable benefit in the various hematologic disorders presently studied and sufficiently well tolerated to make it applicable as a therapeutic modality. The present results confirm the current view that splenectomy has little if any effect in patients with aplastic an

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11546.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.The pituitary function in 20 patients with primary empty sella syndrome has been evaluated. The only endocrine symptom was secondary amenorrhoea in four patients. In half of the patients, pituitary function tests showed minor abnormalities, the most common being impaired growth hormone response to glucagon. In addition to the empty sella, other intracranial abnormalities such as pituitary tumour and hydrocephalus were found in four patients. Although commonly a benign condition, the empty sella may occasionally be associated with clinically important endocrine dysfunction, pituitary tumours and other intracranial abnormalities.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11547.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.The serum concentrations of prolactin (PRL) and thyrotropin (TSH) in 12 males with alcoholic cirrhosis during basal condition and after stimulation with thyrotropin‐releasing hormone (TRH) were compared with the concentrations in ten thiazide‐treated hypertensive and nine normal men. The basal as well as the TRH‐stimulated increase in serum PRL was significantly elevated in the cirrhotic males, while the increase in serum TSH was unchanged, compared with hypertensive and normal men. No correlation between clinical or laboratory parameters and serum PRL was found. Serum estradiol was equal in cirrhotic and control subjects and no correlation was found between serum PRL and serum estradiol. These findings favour the concept that raised serum PRL in cirrhotic patients might be caused by a diminished dopaminergic neurotransmi

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11548.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.Serum concentrations of T4, T3, rT3and TSH were determined before and after cessation of chronic smoking in healthy subjects. Their body weights were measured at the same intervals. Abstention from smoking was monitored through determination of CO content in blood. Cessation of smoking was accompanied by small reductions in serum T4and rT3and by a small rise in serum TSH. Serum T3was not significantly altered. A minor rise in body weight was noticed. It is suggested that smoking promotes a modestly increased secretion of thyroid hormone, which is readjusted to normal following cessation of smoking. The assumed smoking‐induced increase in thyroid hormone secretion is apparently not mediated by enhanced TSH secretion but by some other factor, e.g. the sympathetic nervous system. The hormonal changes might contribute to the increase in body weight frequently seen after cessation of smokin

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11549.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.In a study of 21 patients with recurrent venous thrombosis and/or thrombophlebitis, fibrinolytic activity measured after venous occlusion was significantly improved after treatment with 6 mg Δ4‐ethylestrenoI (Orgabolin®) daily. Seven of the 21 patients had abnormally low vessel wall plasminogen activator content, which normalised during treatment. No tendency to develop resistance to the drug was observed during treatment for periods up to 56 months. This improvement was shown to be combined with a significantly lower (p>0.001) incidence of thrombo

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11550.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

ABSTRACT.Among 55 consecutive coronary care unit (CCU) patients with chest pain of unknown origin at discharge from hospital, signs of oesophageal dysfunction (OD) were found in 58 % and signs of ischaemic heart disease (IHD) in 35 % within 2–6 months. At a three‐year follow‐up, signs of OD were found in 62% and signs of IHD in 28%. Forty‐six patients (84%) had experienced a pain similar to that which caused the CCU admission (i.e. the CCU chest pain). OD was regarded as the cause of the CCU chest pain in seven patients (13%) and as a possible cause in another nine (16%). IHD was regarded as the cause of the CCU chest pain in 17 patients (31%), four of whom had died from acute myocardial infarction during the follow‐up period. All ten patients who developed coronary events, such as myocardial infarction or progressive angina pectoris, during the follow‐up period had an ischaemic ECG reaction at exercise test 2–6 months after discharge from the CCU. IHD was found to be the predominant disease in terms of severity of symptoms and prognosis and was also recorded as the most common single cause of the CCU chest pain. Since OD was common and even caused severe chest pain in some patients, oesophageal origin should be considered in the differential diagnosis of chest pain in non‐infarcti

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1981.tb11551.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY