ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1972.tb03611.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1972.tb03612.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACT:A survey of SLE in an area from central eastern Norway is given, together with clinical and laboratory data on the 72 patients diagnosed as SLE in this area during the years 1959–1963. The main proportion of these cases would have been classified as definite SLE according to diagnostic criteria given in the literature. Annual incidence and prevalence rates were lower than rates presented from other countries. The frequency of various clinical manifestations is consistent with previous reports. The SLE patients were classified according to syndromes they exhibited during the active stages of their disease, and the manifestations in various syndromes were compared.The SLE material serves as a proband material for family studies, and sub‐grouping of SLE cases is the basis for comparison of the findings in relatives of these various groups of SLE proba

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1972.tb03613.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACT:An indirect LE factor technique, including a simple method for separation of leucocytes, is described. In the test a standardized amount of serum reacts with a constant amount of damaged nuclei serving as antigen, and fagocytosis is secured by addition of a constant amount of freshly‐prepared leucocytes. It is possible to titrate LE sera. The titration of LE sera gives a regular succession of different phenomena associated with LE cell. This gradual change in the morphology has been described. Granulocyte‐ and lymphocyte‐specific LE factors are demonst

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1972.tb03614.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACT:LE factor was determined in sera of 928 family members of 72 patients with SLE by an indirect LE factor test. The prevalence of LE factor was significantly increased in relatives compared with their spouses, female first degree relatives presenting the highest frequencies. The presence of LE factor in relatives was correlated to presence of rheumatic disease, but LE factor also occurred in apparently healthy relatives. The frequency of LE factor was independent of size of sibships and families and residence of the relatives.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1972.tb03615.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACT:The distribution of antinuclear factors in sera of 615 relatives, and their 313 spouses, of 72 SLE probands is presented. A statistically significant, but irregular, aggregation of ANFs occurred in relatives. When the different patterns of nuclear fluorescence were analysed, the homogeneous type, but not the speckled type of ANF separated the relatives and the spouses. The correlation between ANFs and rheumatic disease was more manifest for relatives than for spouses. Non‐rheumatic relatives and spouses did not differ with regard to any type of AN

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1972.tb03616.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

ABSTRACT:Antinuclear factors (ANFs) were studied in sera of 51 SLE probands, 615 relatives and their 313 spouses who served as controls.The frequency of ANFs in the relatives was correlated to certain variables present in the SLE probands: i: A very marked accumulation of speckled ANF was found in relatives of SLE probands with marked arthritis, whose female relatives above forty years of age more frequently had a present of past history of effusions in large joints than female relatives of SLE probands without arthritis. The frequency of ANFs in relatives was also correlated with ii: the titer of ANFs in the proband and with iii: the presence of numerous LE cells at the time of diagnosis of SLE in the proband.Selection of subroups of SLE probands with defined clinical and/or serological characteristics appears to be valuable in family studies of SLE.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1972.tb03617.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY