ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01937.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Coronary heart disease (CHD), previously neither diagnosed nor suspected, was strongly suspected in 115 of 2014 men aged 40–59 years during a cardiovascular survey examination. Sixty‐nine of 105 men who underwent diagnostic coronary angiography had pathologic angiograms. Twenty‐six of these 69 had angina pectoris (AP) with and without pathologic exercise ECGs and 43 had pathologic exercise ECG as the only indicator of CHD. The extent of coronary artery changes was similar in the two groups. The men without AP were in almost all respects similar to 1832 men labelled as normals. The men with AP differed in several respects from their non‐AP angiographic counterparts and from the normals: they had more dyspepsia, a higher stress score, higher serum cholesterol and triglycerides, lower antithrombin III levels in the blood and lower blood platelet retention values. These results indicate that coronary artery disease with and without AP may represent somewhat different pathogenetic e

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01938.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The prevalence of symptoms of intermittent claudication and their association with 5‐year mortality were examined in a population study in Finland. A number of 5738 men and 5224 women, aged 30–59 years, from 4 geographic areas of the country were studied. According to a structured interview, 2.1% of the men and 1.8% of the women reported typical symptoms of intermittent claudication. Claudication was most prevalent in East Finland and among persons with agricultural occupations. The symptoms were more frequent in diabetics and persons with symptoms and signs of coronary heart disease (CHD) than in persons without these diseases. High serum cholesterol and smoking were associated with these symptoms but high blood pressure was not. The risk of death from cardiovascular causes was nearly 3‐fold in men with claudication compared to men without claudication. Symptoms of chest pain and smoking increased significantly the mortality risk of male claudicants. The validity of symptoms was poorer in women than in men and they were also less reliable predictors of death in women. A small part of the effect of claudication on mortality was due to its association with conventional CHD risk factors. However, after adjusting for symptoms and signs of CHD, claudication had no independent effect on mortality i

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01939.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Urinary excretion of β‐hexosaminidase was studied in 50 patients with vesico‐ureteric reflux (VUR) in order to obtain information on the renal injury in this disease. There was no correlation between urinary enzyme excretion and the degree of VUR. Patients without pyelonephritic changes and with normal serum creatinine values showed normal excretion of β‐hexosaminidase. Patients with pyelonephritic changes but normal serum creatinine had enzyme activity towards the upper limit of the normal range whilst patients with pyelonephritic changes and decreased renal function (high serum creatinine) showed increased excretion of urinary β‐hexosaminidase. Some of the patients with VUR and asymptomatic bacteriuria exhibited increased excretion of urinary β‐hexosaminidase and six with acute pyelonephritis had very high levels. These findings indicate that the infective process plays an essential role, besides VUR, in the development of

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01940.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The following serum constituents were measured in 19 patients operated on for Graves' disease: calcium, protein, parathyroid hormone (PTH), alkaline phosphatase, thyroxine, triiodothyronine, free thyroxine index, and thyroid‐stimulating hormone. Blood was sampled systematically on the day before and 5 days, 1 month, 2, 3, 4 and 6 months after operation. All patients were pretreated with antithyroid drugs, and 2 months before surgery levothyroxine was added. The study showed that the thyroid function was impaired for 3 months postoperatively. Serum calcium level was lowered in the same period. Serum PTH increased with decreasing serum calcium, and vice versa. The results support the theory that the transient fall in serum calcium level is due to lowered PTH sensitivity in bone tissue caused by temporary impaired thyroid function after surgery. On the other hand, a direct action of lowered thyroid hormone on bone tissue is also a possible explanatio

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01941.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Systolic time intervals, the pre‐ejection period (PEP), left ventricular ejection time (LVET) and PEP/LVET ratio were studied in ten thyrotoxic and ten hypothyroid patients. LVET and PEP intervals were corrected for heart rate (LVETcand PEPc). The measurements were repeated after 1–28 months when the patients were euthyroid following appropriate therapy. Compared with the euthyroid values, the PEPcintervals and PEP/LVET ratios were significantly decreased (p<0.01) in the thyrotoxic and increased (p<0.001) in the hypothyroid patients. In both groups the LVETcintervals were significantly prolonged (p<0.001). In four of the hypothyroid patients the PEP/LVET ratios were markedly increased (above 0.60, mean 0.66), and above 0.41 in the euthyroid state (reference value 0.35±0.05). In the other hypothyroid patients and in thyrotoxic patients the euthyroid PEP/LVET ratios were within the reference values. The systolic time intervals were not influenced by propranolol therapy in the thyrotoxic patients. Our results suggest increased myocardial contractility unaffected by adrenergic blockade in thyrotoxicosis, and reduced contractility in hypothyroi

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01942.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.The serum concentrations of total IgE were significantly raised in smokers compared to those who had never smoked (p<0.005) among male patients with bronchial carcinoma, while no differences were found between smoking and non‐smoking female bronchial carcinoma patients. The total IgE levels in male and female patients with non‐malignant pulmonary diseases were not correlated to smoking habits. No significant differences in the IgE levels were observed between smoking males sub‐grouped according to the WHO histological types of bronchial carcinoma. Males with carcinoma who had stopped smoking more than 10 years ago had significantly reduced IgE levels compared to male cancer patients continously smoking (p<0.01). These data, indicating that smoking is associated with elevated IgE levels in males with bronchial carcinoma, might suggest that smoking in certain, preferably male, individuals induces an impaired cellular immunity which is reflected by an enhanced IgE synthesis and a depressed resistance to carcinogens of tobacco

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01943.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Blood pressure (BP) readings in a physician's office have been reported to be higher than patient‐determined readings at home. This conclusion is based on measurements in various selected groups of patients. In this study, the results of office and home BP readings were compared in three groups of men with high BP sampled from the general population. More than 90% of the men were able to perform the measurements. Among men well accustomed to the office environment, the differences between office and home readings were small and without any clinical importance. Among men less well accustomed to the office atmosphere, the office readings exceeded almost invariably the home B

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01944.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.Release of hypoxanthine and phosphate from exercising legs was studied in eight subjects without known obstructive arterial disease and in 20 claudicants. Lower leg blood flow was measured with a thermodilution catheter in the popliteal/distal femoral vein. The catheter allowed blood sampling from the calf before, during and after exhaustive exercise on a bicycle ergometer at a stepwise increasing load. Resting plasma hypoxanthine levels were higher in claudicants than in normal subjects (p<0.05). Hypoxanthine concentrations increased 2–4‐fold during exercise, amounting to values ten times higher than the resting levels 5 and 10 min post exercise, in the venous effluent of the normal legs. A similar rise was found in the claudicants despite half the exercise intensity at exhaustion. Popliteal venous concentrations of phosphate increased by approximately 25% during exercise without significant differences between the two groups. During exercise the release of hypoxanthine increased 38‐fold and of phosphate 21‐fold in the normal lower legs, while a ten‐fold increase in both metabolites was recorded in the claudicating legs. The study demonstrated a high release of hypoxanthine and phosphate from the human lower leg during rhythmic, exhaustive exercise (with maximal vasodilation). The result is compatible with the assumption that metabolites from the catabolism of adenine nucleotides (adenosine) play a role in the autoregulation of blood flow in human skeletal muscle. Increased plasma hypoxanthine concentrations at rest may indicate peripheral arterial insu

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01945.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

ABSTRACT.In order to analyse the time course effect of thyroxine replacement therapy on lipo‐protein concentrations, 12 hypothyroid subjects were studied before and repeatedly during therapy. The substitution dose was increased gradually every fourth week until the plasma level of TSH became normal. The concentrations of cholesterol and tri‐glycerides were anlysed in whole serum and in the three major lipoprotein fractions VLDL, LDL and HDL. The main abnormality before treatment was an increased LDL cholesterol concentration. Normalization of serum LDL was established at a dose level which normalized TSH. The onset of the effect of thyroxine on LDL cholesterol was rapid and could be noted already after two we

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1982.tb01946.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY