ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03726.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03727.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTEchocardiographic mapping was performed in 44 patients on arrival in hospital and day 2 following acute myocardial infarction (AMI). To evaluate left ventricular (LV) function the per cent deviation of the mean systolic wall velocity (PD‐V) from the normal was measured from 16 LV segments. Adequate data were obtained from 89% of the segments. The number of hypokinetic segments was somewhat higher in anterior than inferior AMI, reaching significance (p<0.05) on day 2. Dyskinetic segments were also more common in patients with anterior infarction (p<0.001), who also had significantly higher enzyme maxima than patients with inferior AMI (p<0.01). Enzyme maxima correlated well with the sum of PD‐V from all hypokinetic segments on day 1 (r= 0.79,p<0.01). Compensatory hyperkinesia was more common in inferior than anterior AMI (p<0.001). Global LV function, estimated by subtracting the number of hyper‐ from hypokinetic segments (score σ S: Adj), was significantly related to heart failure (Killip classification) (p<0.01) and the respiratory rate (r= 0.71,p<0.01) in the acute phase as well as to heart failure during the first post AMI month (New York Heart Association classific

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03728.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTFish‐eye disease is a familial condition characterized by corneal opacities and dyslipoproteinaemia with, i.a., pronounced enrichment of plasma low density lipoprotein (LDL) with triglycerides. Cholesterol ester and triglyceride transferase activities in lipoprotein‐free plasma have been measured in two patients with fish‐eye disease and found to be normal. This indicates that a deficiency of plasma lipid transfer protein is not involved in the abnormal composition of LDL in fish‐eye

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03729.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTThe serum high density lipoprotein (HDL) and total cholesterol levels and their determinants were explored in a random population sample from eastern Finland, an area with an exceptionally high mortality and morbidity from coronary heart disease (CHD). A total of 1792 persons aged 14–65 years were studied. Serum HDL cholesterol was determined in one series by using an enzymatic method after precipitation by dextran‐magnesium chloride. The mean serum HDL cholesterol was 1.41 mmol/l in men and 1.62 mmol/l in women. Although a multivariate linear regression model explained 21% (for men) and 28% (for women) of the variation in serum total cholesterol, the same variables were able to account for only 9 and 4%, respectively, of the variation in serum HDL cholesterol. Among men, obesity and the daily consumption of tobacco products were inversely associated and the weekly consumption of beer and age were directly associated with serum HDL cholesterol and the serum HDL cholesterol/total cholesterol ra

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03730.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTThere have been conflicting reports concerning the relationship between increased alcohol intake and mortality from ischaemic heart disease. In this investigation, social register data also containing life‐long registration data for alcoholic intemperance were related to cause of death for 302 men aged 35–44 in 1968–74. A random population sample of 940 male survivors of the same age was used for comparison. “Social problems only” were less common for the deceased, irrespective of cause of death, than for the controls. Registration for alcoholic problems was significantly more common for ischaemic heart disease, accidents, suicide and “other deaths” but not for cancer. The variables “detained by the police for drunkenness” and “in prison for crime” showed similar associations. Possible explanations are discussed, especially the association between alcoholic intemperance and death from ischaemic heart disease. The most probable mechanism is effects on the myocardial cell enzyme functions with following arrhythmias in subjects susceptible to malignant arrhythmias due to coronary artery disease and

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03731.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTIn 42 patients with systemic lupus erythematosus, clinically normal oral mucosa was investigated with direct immunofluorescence technique for the presence of immunoglobulins G, A and M and complement factor C3 in the mucosal basement membrane zone (the lupus band test, LBT). Punch biopsies were performed in the posterior part of the hard palate (n= 39) or the lower labial mucosa (n= 3). The immunopathological observations were compared with clinical and serological data. The LBT was positive for IgM in 45% of the patients and trace amounts of IgM were found in another 19%. In 7 cases (17%) either IgG, IgA or C3 were found in addition to IgM and these patients all had a severe form of the disease, while the presence of IgM only was not correlated to clinical parameters.

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03732.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTSelf‐poisoning with antidepressant drugs was studied retrospectively in 225 patients admitted to an intensive care unit. Amitriptyline accounted for the overwhelming majority of cases (70%); 106 patients (47%) had taken two or more drugs, in 81 patients (36%) ethanol was found in the blood. Four patients (2%) died. On admission, 111 patients (49%) were unconscious (grade III). A further 30 patients (13%) were in grade IV coma, and of these 27 had taken amitriptyline. Twenty‐four hours after admission, 22 patients (10%) remained in coma. Thirty‐six patients (16%) required assisted ventilation. Nineteen patients (8%) had convulsions and 6 (3%) aspired stomach contents. Sixty‐one patients (27%) had a widened QRS interval exceeding 100 msec, 18 (30%) of them required assisted ventilation, 21 (34%) were in stage IV coma and 15 (25%) had convulsions. This relationship between a widened QRS interval and the severity of intoxication should be considered in the initial assessment of patients with tricyclic antidepressant po

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03733.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTTo determine whether an aspiration biopsy of liver and/or spleen is likely to reveal a clinically silent malignant infiltration, fine‐needle aspiration biopsies were carried out in 180 patients with a diagnosed malignancy in whom neither the liver nor the spleen gave signs of involvement in sonography. Few, if any, findings were positive in patients with cancer or Hodgkin's disease. In non‐Hodgkin lymphoma, about 25% of the biopsies were positive for malignancy or aroused suspicion of malignancy. We conclude that fine‐needle aspiration biopsies of the liver and spleen may be of value in the clinical follow‐up of non‐Hodgkin

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03734.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

ABSTRACTThe influence of improved diabetic control on peripheral nerve function was studied before and 3–4 months after institution of insulin treatment in 22 diabetics unsatisfactorily controlled by oral hypoglycemic agents. After institution of insulin treatment, diabetic control was improved as demonstrated by decreasing levels of HbA1. There was an overall tendency towards improvement of motor and sensory conduction velocities, however significant only in the upper extremities. There was a tendency towards improved temperature sensitivity in the legs, while no changes occurred in the hands and face. The sensation for vibration did not change. It is concluded that improved diabetic control, even in elderly patients with long‐standing diabetes, is followed by neurophysiological signs of improved peripheral nerve funct

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1983.tb03735.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY