ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10954.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Altogether 6523 persons aged 25–64 years were studied in eastern and south‐western Finland to determine their cardiovascular risk factor levels. Among men, smoking was more prevalent in the south‐western area (41 vs. 37%), serum cholesterol levels were higher in the eastern area (6.2 vs. 6.0 mmol/l) and blood pressure levels were the same in both areas (145/86 in the east vs. 14/86 in the south‐west). Among women, smoking was also more common in the south‐western area (24 vs. 16%) and serum cholesterol levels were higher in the eastern area (6.1 vs. 6.0 mmol/l) as well as blood pressure levels (142/84 vs. 138/81 mmHg). Among both genders, prevalence of hypertension and proportion of persons on antihypertensive drug therapy was higher in eastern Finland. The comparison of these findings with the results from previous studies carried out among men in these two areas indicates that the risk factor levels have been decreasing in both areas and that the previously observed differences in risk factor levels between eastern and south‐western Finland (the levels used to be higher in the east) have levelled off. The favourable development in eastern Finland may be a result of the North Kare

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10955.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.In a population‐based sample of 409 stroke patients, autopsy was performed in 82 of the 95 patients who died during the first three months and in 61 of the 128 patients dying thereafter. The dominant causes of death, as verified by autopsy, were cerebrovascular disease in the first week (90%), pulmonary embolism in the second to fourth week (30%), bronchopneumonia during the second and third months (27%) and cardiac disease, mainly myocardial infarction, later than three months after the stroke (37%). Death was attributed to causes other than the brain lesion in 59% of the patients with ischemic and in 24% of the patients with hemorrhagic stroke (p<0.01). Age and sex had little influence on the distribution of causes of death. Fatal pulmonary embolism and bronchopneumonia surprisingly often occurred in ambulatory patients. An intracardiac thrombus was present in 20% of deceased patients with atrial fibrillation, and in 17% of cases with a history of myocardial infarction. When attempts are made to reduce mortality (and morbidity) after stroke, there would seem to be a considerable potential for prevention and early treatment of complications, such as pulmonary embolism, bronchopneumonia and cardiac disorder

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10956.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.In order to detect deep vein thrombosis (DVT), 101 patients with acute medical or infectious disorders were examined with the125I‐fibrinogen uptake test. All patients were bedridden on admission and were scanned daily from the second to the eighth day. Thirteen patients developed a positive fibrinogen uptake test. Thus, if a positive test is interpreted as DVT, the incidence of DVT was 13% in our bedridden patients. Of the patients admitted because of heart disease or pneumonia 20% had DVT, but only 4% of those admitted with other diagnoses. Other clinical “risk factors” studied, could not identify patients who develope

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10957.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.The prevalence of snoring, overweight and systemic hypertension was estimated in a random sample of 4064 Swedish men, aged 30–69 years. Of the responders, 15.5% complained of habitual snoring and 29.6% of occasional snoring. Although there was an age‐related increase in the prevalence of snoring up to 60 years, habitual snoring was found to be mainly related to body mass index (BMI) (p<0.0001) but not to age. Altogether 299 men (9.3%) reported hypertension, 21.5% of whom were habitual snorers, compared with 14.9% of the non‐hypertensives (p<0.01). The hypertensives were also more often overweight. Logistic multiple regression analyses showed that among subjects 40–49 years old there was an average increase in the predicted prevalence of hypertension from 6.5% among non‐snorers to 10.5% of habitual snorers in the same weight group. For the whole study population, however, the increase was mainly dependent on age and BMI. Thus, the importance of habitual snoring for the prevalence of hypertension differs in various a

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10958.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.There is epidemiologic evidence of a relationship between calcium deficiency and hypertension. The present study evaluated the effects of alphacalcidol, a synthetic analogue of active vitamin D, given to 29 patients with marginal, intermittent hypercalcaemia. Before therapy there was aninverserelationship between serum calcium levels and diastolic blood pressure (p<0.02). Treatment with 1 μg alphacalcidol raised the serum calcium by 0.07 mmol/l during a 6‐month, double‐blind, placebo‐controlled trial and caused a significant reduction of diastolic blood pressure by 9.2 mmHg compared with placebo (p<0.01). The study extends previous observations, in normocalcaemic subjects, of inverse relationships between serum calcium and blood pressure indicating a primary disturbance of calcium homeostasis in hypertension. The observation that a physiologic amount of active vitamin D has hypotensive effects agrees with such a concept and suggests a new principle for the treatment of hypert

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10959.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.Bradyarrhythmias are sometimes observed in hypothyroid patients. This phenomenon could either be due to the disease process with structural changes of the heart or to an abnormal hormone level. The purpose of the present paper was to study the prevalence of bradyarrhythimas in hypothyroid patients on long‐term substitution therapy. Nineteen subjects were studied 9–53 months after they had reached the final thyroxine substitution level. Ambulatory ECG registrations were performed during 48 hours. Ventricular ectopic beats were observed in 10 of the 19 patients, but no bradyarrhythmias were detected. The results support the notion that arrhythmias found in hypothyroid patients are at least mainly due to the low thyroid hormone le

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10960.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.All patients hospitalized during a 3‐year period with an acute myocardial infarction were followed for the occurrence of reinfarction or death. The patients with diabetes mellitus (n=95) were compared with the non‐diabetic population (n=545). The diabetics had a higher mortality rate (relative death rate of 1.44 vs. 0.93,p<0.01) and a higher frequency of reinfarctions (18.9 vs. 10.8%,p=0.04) than the non‐diabetic population. A larger proportion of the diabetics had suffered a previous infarction, but the excess mortality was also present in those without a previous infarction. Established risk factors for death after myocardial infarction, such as age, infarct size, infarct localization and heart size, could not account for the difference in mortality. It is suggested that the increased mortality among the diabetics may be due to an increase in the rate of progression of the atherosclerotic heart di

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10961.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.In diabetes mellitus cardiovascular mortality among patients with increased urinary albumin excretion seems to be higher than in patients with normal urinary albumin excretion. Therefore we investigated blood pressure, total cholesterol, fibrinogen and in vivo platelet adhesion in 61 patients with type I (insulin‐dependent) diabetes, 39 without complications, such as retinopathy or proteinuria and 22 with proteinuria and slightly elevated serum creatinine. The two groups had similar age, sex, diabetes duration and glucose control. Blood pressure, total cholesterol, fibrinogen and in vivo platelet adhesion were all significantly elevated in patients with proteinuria (p<0.01), whereas these parameters were normal in the uncomplicated diabetic patients, independent of diabetes duration. The mortality of cardiovascular disease during 20 years' follow‐up was significantly higher among patients with proteinuria compared with patients without proteinuria (p<0.001), indicating that these risk factors contribute to the increased cardiovascular mortality in patients with clinical nephropa

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10962.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

ABSTRACT.The aim of the present study concerning patients with long‐term insulin‐dependent diabetes mellitus was to determine whether the serum lipid and lipoprotein concentrations differ in subjects with and without residual insulin secretion. We also investigated whether factors such as sex, smoking, physical activity and microvascular lesions were associated with particular lipoprotein profiles. C‐peptide excretion (≥0.2 nmol) in 24‐hour urine samples was used as an indicator of residual insulin secretion. Twenty‐two pairs of patients with and without residual insulin secretion matched for age at onset and disease duration were participating in the investigations of glycaemic control and microvascular lesions. The HbA1Cwas significantly lower in C‐peptide excretors than in the non‐excretors (6.9±0.3 vs. 7.9±0.3%,p<0.025). The lipids and lipoprotein fractions were all within normal limits. The HDL2/3ratio was significantly higher in C‐peptide excretors than in non‐excretors (1.72±0.28 vs. 1.10±0.09,p<0.05). Multiple regression analysis showed that factors, such as physical activity, body mass index and glycaemic control could explain more of the variation in the different lipid and lipoprotein fractions than residual C‐peptide excretion alone. The only fraction correlating with C‐peptide excretion was HDL3cholesterol. It is concluded that minute residual insulin secretion per se is of minor importance for the regulation of lipids and lipoproteins. Glucose control and residual insulin secretion together with environmental factors seem to be of great importance for the regulation of the lipid and lipoprotein levels in insulin

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1987.tb10963.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY